Objective

Primary Objective
To compare haemodynamic responses to intubation between intravenous and nebulised dexmedetomidine

Secondary Objectives
To evaluate postoperative sore throat incidence
To assess 24 hour analgesic requirements
To monitor postoperative sedation levels using RASS
To observe and compare any side effects

Study Design

Type
Hospital based randomised double blind prospective study

Sample Size
100 patients divided into two groups
Group D Intravenous dexmedetomidine
Group N Nebulised dexmedetomidine

Study Duration
Till completion of sample size after ethics approval

Inclusion Criteria

ASA physical status I and II
Age between 18 and 60 years
Normal airway
Consent for general anaesthesia

Exclusion Criteria

ASA status III or above
Difficult airway
Obesity
Known cardiac respiratory or neurological disease
Allergy to study drugs
Refusal to participate

Methodology

Patients randomly assigned to two groups
Group D receives intravenous dexmedetomidine 1 microgram per kg over 10 minutes
Group N receives nebulised dexmedetomidine 1 microgram per kg in normal saline
Monitoring of HR BP MAP SpO2 and RASS scores pre and post intubation
Assessment of postoperative sore throat and analgesic requirement up to 24 hours

Analysis

Data analyzed using SPSS software
Statistical tests include t test chi square and ANOVA
P value less than 0 point 05 considered significant

Ethical Approval

Study will be conducted after approval from Institutional Ethics Committee
Written informed consent will be taken from all participants
Study drug is FDA approved and used under supervision