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CTRI Number  CTRI/2025/09/095140 [Registered on: 19/09/2025] Trial Registered Prospectively
Last Modified On: 11/09/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group, Placebo Controlled Trial 
Public Title of Study   Homoeopathy in the treatment of warts 
Scientific Title of Study   Efficacy Of Individualized Homoeopathy In The Treatment Of Warts: A Double Blind, Randomized, Placebo Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Renu Mittal 
Designation  Research Officer (Homoeopathy)/ Scientist IV 
Affiliation  Central Council for Research in Homeopathy 
Address  Room no. 304, Central Council for Research in Homoeopathy, 61-65,Jawahar Lal Nehru Chikitsa Avum Anusandhan Bhawan, Institutional Area, Opposite D Block Janakpuri, New Delhi, India

South West
DELHI
110058
India 
Phone  9717511115  
Fax    
Email  renumittal8@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Renu Mittal 
Designation  Research Officer (Homoeopathy)/ Scientist IV 
Affiliation  Central Council for Research in Homeopathy 
Address  Room no. 304, Central Council for Research in Homoeopathy, 61-65,Jawahar Lal Nehru Chikitsa Avum Anusandhan Bhawan, Institutional Area, Opposite D Block Janakpuri, New Delhi, India

South West
DELHI
110058
India 
Phone  9717511115  
Fax    
Email  renumittal8@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Divya Taneja 
Designation  Research Officer (Homoeopathy)/ Scientist III 
Affiliation  Central Council for Research in Homeopathy 
Address  Room no. 309, Central Council for Research in Homoeopathy, 61-65, Jawahar Lal Nehru Chikitsa Avum Anusandhan Bhawan, Institutional Area, Opposite D Block Janakpuri, New Delhi, India

South West
DELHI
110058
India 
Phone  9810305068  
Fax    
Email  drdivyataneja@gmail.com  
 
Source of Monetary or Material Support  
Central Council For Research In Homoeopathy 
 
Primary Sponsor  
Name  Central Council For Research In Homoeopathy 
Address  61-65,Jawahar Lal Nehru Chikitsa Avum Anusandhan Bhawan, Institutional Area, Opposite D Block, Janak Puri, New Delhi, India  
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 8  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nidhi Mahajan   Central Research Institute (H), Jaipur  Department of Clinical Research, OPD No 6, Sector 26, Pratap Nagar, Jaipur- 302033, Rajasthan
Jaipur
RAJASTHAN 		 9119124757

drnidhimahajan1@gmail.com 
Dr Renu Bala  Clinical Research Institute for Homoeopathy, Lucknow  Department of Clinical Research, OPD No 4, Campus of National Homoeopathic Medical College & Hospital, 1, Viraj Khand, Gomti Nagar, Lucknow- 226010, Uttar Pradesh
Lucknow
UTTAR PRADESH 		 9140570079

drrenu3011@gmail.com 
Dr James Michael  Clinical Research Unit (H), Aizawl  Department of Clinical Research, OPD No 4, 3rd Floor, Ayush OPD Building, Block-D, Civil Hospital, Dawrpui, Aizawl-796001, Mizoram
Aizawl
MIZORAM 		 9958994325

jamesmichael312@gmail.com 
Dr Santosh Tamang  Clinical Research Unit (H), Gangtok  Department of Clinical Research, OPD No 3, Development Area, Near Sangram Bhawan Indira Byepass, Gangtok- 737102
East
SIKKIM 		 8250332201

crugangtok@gmail.com 
Dr Hiren Natvarlal  Clinical Research Unit (H), Puducherry  Department of Clinical Research, OPD No 2, 14, 6th Cross, Jawahar Nagar, Puducherry- 605005, Tamilnadu
Pondicherry
PONDICHERRY 		 7396561012

dr.hirenkamalia@gmail.com 
Dr G R C Reddy  Clinical Research Unit (H), Tirupati  Department of Clinical Research, OPD No 2, Srabanam Campus, Old Maternity Hospital Campus, Tirupati- 517507, Andhra Pradesh
Chittoor
ANDHRA PRADESH 		 9441208007

dr.grcreddy@gmail.com 
Dr D Kartikeyan  Homoeopathy Research Institute for Disabilities, Chennai   Department of Clinical Research, Room No- 136, NIEPMD Campus, ECR, Muttukadu, Chennai- 603112, Tamilnadu
Chennai
TAMIL NADU 		 8281488685

drkarthikeyanmd@gmail.com 
Dr Ranjit Sonny  Regional Research Institute (H), Siliguri  Department of Clinical Research, OPD No 1, Siliguri-734012
Darjiling
WEST BENGAL 		 9883202281

rrih-siliguri@ccrhindia.nic.in 
 
Details of Ethics Committee  
No of Ethics Committees= 9  
Name of Committee  Approval Status 
Central Ethics Committee  Approved 
Central Ethics Committee  Approved 
IEC, CRI(H), JAIPUR  Approved 
IEC, CRI(H), LUCKNOW  Approved 
IEC, CRU(H), PUDUCHERRY  Approved 
IEC, CRU(H), TIRUPATI  Approved 
IEC, RRI(H), AGARTALA  Approved 
IEC, RRI(H), Guwahati  Approved 
IEC, RRI(H), SILIGURI  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: B079||Viral wart, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Indicated Homoeopathic medicine   Indicated homoeopathic medicine based on individualized symptom totality in compliance with pharmacopoeial standards from GMP compliant manufacturers would only be used. The medicines would be taken orally in form of pills (sugar globules) of standard size 30, saturated with homoeopathic dilutions for 6 months No new drug will be used.  
Comparator Agent  Placebo  Identical placebo saturated with 83.1% v/v ethyl alcohol would be used for 6 months. The placebo will also be dispensed in sugar globules of standard size 30 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  All types of cutaneous warts
Single wart sized equal or more than 2 mm/ multiple warts wherein at least one wart should be equal or more than 2 mm  
 
ExclusionCriteria 
Details  Anogenital warts, Bowenoidpapulosis, focal epithelial hyperplasia or seborrhoric keratosis.
History of skin cancer
Treatment with immune-modulating oral medications like corticosteroids in past 04 weeks
Patient on homoeopathic treatment for any disease condition.
Self-reporting cases of HIV
Pregnant and lactating women
Advance disease of any vital organs
 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded 
Primary Outcome  
Outcome  TimePoints 
Percentage of warts disappeared
Regression in the Size and number of warts (in millimeter scale) 		 At baseline, 15 days, 1 month, 1.5 months, 2 months, 2.5 months, 3 months, 3.5 months, 4 months, 4.5 months, 5 months, 5.5 months, 6 months  
 
Secondary Outcome  
Outcome  TimePoints 
Change in Dermatological life quality index (DLQI) questionnaire score  Baseline, at the end of 1 month, 3rd month and 6th month 
Identification of specific HPV genotypes in patients suffering from warts on a sample of patients  Baseline 
 
Target Sample Size   Total Sample Size="310"
Sample Size from India="310" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 3 
Date of First Enrollment (India)   15/10/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="2"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This is a multicentric, Randomized, double blind, placebo controlled study which will be undertaken in the special dermatology clinics operating in the research centers of the Council. The dermatology clinics are managed by trained homoeopathic practitioners with research experience. The clinics provide routine OPD care to patients suffering from dermatological disorders using homoeopathic medicines only. The primary objective is to evaluate response to individualized homoeopathic treatment for disappearance or resolution of warts and secondary objective is to assess and compare the effect of homoeopathic medicine in warts on the basis of Dermatological life quality index (DLQI) questionnaire score and to identify specific HPV genotypes and their correlation with homoeopathic treatment outcomes on a sample of patients. The participants aged 18 to 65 years, both gender will be enrolled under the study. All types of cutaneous warts, single or multiple wherein one wart should be atleast more or equal to 2 mm will be included under the study. The outcome assessment will be done on the basis of percentage of warts disappeared, regression in the size and number of warts (in millimeter scale) to be assessed on fortnightly basis and change in the dermatological life quality index score at baseline, at the end of 1 month, 3rd month and 6th month.


 
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