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CTRI Number  CTRI/2025/07/091779 [Registered on: 25/07/2025] Trial Registered Prospectively
Last Modified On: 25/07/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Placebo Controlled Trial 
Public Title of Study   Which Works Better for Early Knee Osteoarthritis: Kinesiology Taping or Mulligan’s Movement Therapy? 
Scientific Title of Study   A Single Blinded Randomized Controlled Trial to Compare the Effectiveness of Kinesiology Taping and Mulligan’s Mobilization with Movement in Patients with Early Knee Osteoarthritis 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  STPriya 
Designation  Student 
Affiliation  SRM Institute of Science and Technology Trichy 
Address  4th floor Medical college building SRM Institute of Science and Technology Irugalur Tiruchirappalli
SRM Institute of Science and Technology
Tiruchirappalli
TAMIL NADU
621105
India 
Phone  9360097765  
Fax    
Email  stpriya2712@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  S Selvin James 
Designation  Assistant Professor 
Affiliation  SRM Institute of Science and Technology, 
Address  4th floor , Medical college building,

Tiruchirappalli
TAMIL NADU
621105
India 
Phone  9994437109  
Fax    
Email  rajinijames@gmail.com  
 
Details of Contact Person
Public Query  
Name  S Selvin James 
Designation  Assistant Professor 
Affiliation  SRM Institute of Science and Technology, 
Address  4th floor , Medical college building,

Tiruchirappalli
TAMIL NADU
621105
India 
Phone  9994437109  
Fax    
Email  rajinijames@gmail.com  
 
Source of Monetary or Material Support  
SRM Medical college hospital & research centre Tiruchirappalli Tamil nadu India 621105  
 
Primary Sponsor  
Name  STPriya 
Address  4th floor Medical college building SRM Institute of Science and Technology Irugalur Tiruchirappalli Tamil nadu India 621105 
Type of Sponsor  Research institution and hospital 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Mr S Selvin James  Trichy SRM Medical College Hospital and research centre  Irungalur, Tiruchirapalli - 621105
Tiruchirappalli
TAMIL NADU 		 9994437109

rajinijames@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
TRICHY SRM IEC  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  osteoarthritis knee 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Kinesiology Taping   Group A will receive Kinesiology Taping will be applied for 3 session over 2 weeks  
Intervention  Mulligans Mobilization with Movement  Group B will receive Mulligans Mobilization with Movement technique will be applied for 3 session over 2 weeks  
Comparator Agent  Standard Exercise Protocols  Group C is Control Group will receive Standard Exercise Protocols for 3 sessions over 2 weeks 
 
Inclusion Criteria  
Age From  40.00 Year(s)
Age To  65.00 Year(s)
Gender  Both 
Details  Unilateral Knee Osteoarthritis and Kellgren Lawrence grade 1 and 2 
 
ExclusionCriteria 
Details  Knee Infections and Knee Surgeries and Rheumatoid Arthiritis 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
Reducing the Pain assessed by Numerical Pain Rating Scale (NPRS), Functional Activity assessed by Western Ontario McMaster Osteoarthritis Index (WOMAC) Scale  The baseline assessed in 2 weeks for NPRS and WOMAC  
 
Secondary Outcome  
Outcome  TimePoints 
Quality of Life assessed by Quality of Life Shortform - 36  The baseline assessment on 2 weeks 
 
Target Sample Size   Total Sample Size="90"
Sample Size from India="90" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 1/ Phase 2 
Date of First Enrollment (India)   08/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="3"
Days="0" 
Recruitment Status of Trial (Global)   Open to Recruitment 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Patients referred from various departments such as the Orthopedic department will be recruited and the written consent form will be obtained from the patients. The patients will randomly be allotted into three groups by computer generated random sampling method and each group consist of 30 patients. After which a baseline assessment will be done for everyone who are recruited by physiotherapist who will be blinded in  this study. Then the intervention is 3 sessions over 2 weeks will be given to those in the intervention group, Either Kinesiology Taping and Exercises or (MWM) Mobilization with Movement and Exercises. Those in the controlled group will receive the conventional treatment for Knee Osteoarthritis. Once the treatment sessions are over a post assessment will be done by the physiotherapist who will be blinded in this study. After which the Statistical Analysis will be done and the results will be revealed. 
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