The bladder’s function is to store and release urine. In some individuals, the bladder muscle becomes weak and cannot contract properly, leading to a condition called Detrusor Underactivity (DUA). This results in difficulty in emptying urine, urinary retention, and dependence on catheters for voiding. Current treatments such as intermittent catheterization or medications are only partially effective and carry risks like infections.

Platelet-Rich Plasma (PRP) is a biological product prepared from a person’s own blood, containing platelets that release multiple growth factors known to promote healing and regeneration of muscles and nerves. PRP has been successfully used in other medical fields to repair tissues but has limited research in bladder muscle repair.

In this study, we propose to use PRP therapy to improve bladder muscle function in patients with DUA. After taking a small blood sample from the participant, PRP will be prepared, activated, and injected into the bladder muscle through a minor cystoscopic procedure. This process will be done once, with a possible booster injection after 3 months if needed.

Participants will be followed up at 1, 3, 6, and 12 months to assess improvement in urination, bladder emptying, bladder pressures, symptom scores, and any side effects. No participant will be charged for participation, and all safety measures will be in place.

The goal of this study is to explore whether PRP therapy can provide a safer, less invasive regenerative treatment option for DUA patients, potentially improving their quality of life and reducing dependency on catheters.

Participation is voluntary, and patients can withdraw from the study at any time without affecting their routine medical care.