Functional mandibular shifts (FMSH) and occlusion in any plane (transeverse, anterior, posterior or complex) tends to become habitual because of constant neural feedback from proprioceptive receptors situated in periodontal membrane to the brain.

This neural feedback, if not broken at early age, the bony changes in TMJ, and/or maxilla and mandible may become skeletal deformity with age advancement, treating which becomes increasingly difficult task.

A good balance of masticatory and head and neck muscles seems to be an important factor of postural stability.

No improvement was found in posture in sagittal plane malocclusions when patients were in adult age (18 - 52 years) with permanent dentition.

Moreover, true anterior, posterior and lateral FMSH have been studied extensively but FMSH occurring because of the factors arise during complex changes in deciduous and early mixed dentition have not been researched yet.

Functional occlusion shifts with altered condylar spatial articulation in glenoid fossa has potential to modify TMJ morphology, mandibular asymmetry, asymmetric muscle activity, which are minor in pediatric patients but become aggravating problem with age progression.

Palatal and/or dental expansion has been studied extensively for functional unilateral crossbite (UPXB) cases. Researchers treated UPXB patients with expansion and could achieve complete crossbite elimination in 50% of the cases only. Asymmetric posterior occlusion remained prevalent in treated cases. Also, reverse sequencing was reduced but not eliminated post-treatment.

On the other hand, patients in mixed dentition age, treated with reflex releasing occlusal splint in removable palatal expander showed complete elimination of UPXB and midline shifts along with symmetric spatial location of condyles in glenoid fossa. Similar stable results were found when neuro-occlusion was established in patients (3-6 years) with planas direct tracks and selective grinding. There was self-correction of maxillary arch constriction in these patients.

It seems evident that neuro-occlusion rehabilitation alone before 6 years of age and prior to expansion in mixed dentition age group results in stable CO-CR synchronicity.

Whether breaking the eccentric proprioception and neural feedback with reflex releasing diagnostic splint in all the FMSH cases be it in any plane as described above, would bring mandible in neuro-occlusion, still remain a dilemma.

Secondly reflex releasing splints serve as diagnostic tools to prove developing malocclusion as functional that some environmental factors are acting on teeth, bone, muscle system. However, studies are very limited to validate this hypothesis. 

No study could be found correlating effect of neuro-occlusion establishment on dental, skeletal and posture altogether.

Therefore, the aim of this study is to assess dental, functional, postural and skeletal changes pre and post neuro-occlusion rehabilitation using diagnostic reflex releasing splint in children with deciduous and early mixed dentition with functional shift of mandible.

Null hypothesis is that there is no effect of diagnostic reflex releasing splint on dental, skeletal, functional, and posture in patients with functional mandibular shift.