This study will investigate whether a patient’s nutritional and health status can predict their tolerance to chemotherapy by examining geriatric cancer patients at Shirdi Sai Baba Cancer Hospital in Manipal. The selection criteria will focus on elderly individuals (60+) who are scheduled for chemotherapy and are able to participate fully in the study. The methodology involves a two-phase approach: a baseline assessment before treatment and a follow-up after 3 chemotherapy cycles. The initial assessment will collect extensive data, including anthropometric measurements (weight, height, MUAC, calf circumference), muscle strength via handgrip dynamometer, skinfold thickness via a skinfold caliper and validated nutritional assessments (MNA) and quality of life surveys (SF-36). Additionally, biochemical parameters will be taken to measure key serum proteins like albumin, globulin and total serum protein from the hospital report. The dietary assessment will be carried using 24 hour recall and a food frequency questionnaire. The follow-up will repeat these measurements and document the severity of any chemotoxicity using established clinical criteria, such as the CTCAE, to correlate the patient’s initial health with their treatment outcome. This comprehensive approach aims to create a predictive model for chemotoxicity risk, enabling healthcare providers to identify and intervene with at-risk patients before they begin treatment.