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CTRI Number  CTRI/2025/07/090740 [Registered on: 11/07/2025] Trial Registered Prospectively
Last Modified On: 09/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Surgical/Anesthesia 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Comparison of single(adductor canal block) versus two blocks(adductor canal blockand IPACK block) for postoperative analgesia after knee surgery in adult patient.  
Scientific Title of Study   Randomized study to compare adductor canal block and combination of adductor canal block with ipack block for post operative analgesia in adult patient undergoing knee surgery 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Rushali Thakkar 
Designation  Second year resident doctor anesthesiology 
Affiliation  B J Medical college Civil hospital 
Address  F3 department of anesthesiology Civil hospital Ahmadabad Gujrat 380016

Ahmadabad
GUJARAT
380016
India 
Phone  8320525339  
Fax    
Email  rushalithakkar7299@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Smita R Engineer 
Designation  Professor and Head of department Anesthesiology  
Affiliation  B J Medical college Civil hospital 
Address  F3 department of anesthesiology Civil hospital Ahmadabad Gujrat 380016

Ahmadabad
GUJARAT
380016
India 
Phone  9825504948  
Fax    
Email  seng_90@yahoo.com  
 
Details of Contact Person
Public Query  
Name  Dr Smita R Engineer 
Designation  Professor and Head of department Anesthesiology  
Affiliation  B J Medical college Civil hospital 
Address  F3 department of anesthesiology Civil hospital Ahmadabad Gujrat 380016

Ahmadabad
GUJARAT
380016
India 
Phone  9825504948  
Fax    
Email  seng_90@yahoo.com  
 
Source of Monetary or Material Support  
Government of gujrat Health and family welfare department 7th floor new sachivalay Gandhinagar 382010 Gujrat India 
 
Primary Sponsor  
Name  Government of gujrat 
Address  Health and family welfare department 7th floor new sachivalay Gandhinagar 382010 Gujrat India 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Rushali Thakkar  Trauma center civil hospital Ahmadabad  Orthopedic surgery operation theater at 4th floor trauma center civil hospital Ahmadabad
Ahmadabad
GUJARAT 		 8320525339

rushalithakkar7299@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
The Institutional Ethics Committee B J medical college and civil hospital ahmedabad  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M239||Unspecified internal derangement of knee,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Adductor canal block   Effects of adductor canal block(Inj. bupivacaine 0.125% 20ml)for postoperative period 24 hours in adult patients undergoing knee surgery 
Intervention  Combination of adductor canal block and IPACK block   combine effects of adductor canal block(Inj. bupivacaine 0.125% 10ml)and ipack(Inj. bupivacaine 0.125% 10ml)for postoperative period 24hours in adult patients undergoing knee surgery  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  75.00 Year(s)
Gender  Both 
Details  Patients willing to consent for the study
BMI-18-35 kg/m2
American Society of Anesthesiologist (ASA) Classification I, II, III
Elective Knee Surgery under spinal anesthesia 
 
ExclusionCriteria 
Details  Patients with pre-existing respiratory diseases, cardiac diseases
Pregnant patients
Patients with history of bleeding disorders or on anticoagulant therapy
Patient refusal to participate in study
Infection at or near injection site
H/O previous knee surgery
Allergy to local anesthetics
Bilateral knee arthroplasty
Patient with neuropathic pain of lower limb 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   Alternation 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
POSTOPERATIVE PAIN SCORE EVALUATED BY VRS(VERBAL RATING SCORE)
1.VRS(R)AT REST
2.VRS(M)AT MOVMENT 		 Time from block to be given preoprative to the 24 hours postoperative period. 
 
Secondary Outcome  
Outcome  TimePoints 
1.Intra operative and post operative hemodynamic monitoring.
2.Post-operative requirement of opioid Analgesic.
3.Incidence of complication related to block(numbness,infection,hematoma).
4.Patient satisfaction score-a verbal neumeric rating scale of patient satisfaction will be obtained in post operative period(no satisfaction/partial satisfaction/complete satisfaction).
 		 Time from block to be given preoprative to the 24 hours postoperative period. 
 
Target Sample Size   Total Sample Size="80"
Sample Size from India="80" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   25/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="2"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Effective pain management after knee surgery is crucial for early mobilization and reduced hospital stays. Peripheral nerve blocks have become preferred techniques to control postoperative pain while minimizing opioid use and related side effects. Among these, the adductor canal block (ACB) offers good analgesia while preserving quadriceps strength, aiding faster rehabilitation by targeting key sensory nerves around the knee. However, ACB alone does not adequately cover posterior knee pain. The IPACK block, which anesthetizes terminal sciatic nerve branches, complements ACB by addressing posterior knee discomfort without causing foot drop. So this study is plane to evaluate and compare the effect of combination of these two block. 
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