The study is Randomized, parallel group, open label, comparative clinical trial to evaluate the efficacy and safety of Majoon Najah and Sharbat Ahmed Shahi in the management of Depression. Depression is a common illness characterized by persistent sadness and a loss of interest in activities that one normally enjoys, accompanied by an inability to carry out daily activities, for at least two weeks. It is a serious mental health concern that impacts a person’s ability to work, their relationships, and significantly destroys their quality of life. It is believed that severe depression can have devastating consequences including suicidal ideation and attempts. About 3.8 percent of the population suffers from depression, including 5 percent of adults. Approximately 280 million people in the world have depression. Women are 50 percent more likely to experience depression when compared to men with a prevalence rate of 6 percent among women and 4 percent in men. The National Mental Health Survey 2015 in India reports that 1 in 20 individuals aged 18 or older have suffered from depression at least once in their lifetime. More than 700 000 people die by suicide every year. The World Health Organization estimates that depression accounts for 4.3 percent of the global disease burden and projects that it will become the leading contributor by 2030. In modern medicine, first-line course of antidepressant treatment is insufficient to achieve remission in 68 percent of cases. The current antidepressants used have limitations in both efficacy and tolerability. The scientists are increasingly focusing on exploring and developing new antidepressant drugs derived from plants and their active compounds. Unani medicine is known for being safe, effective, readily accessible, cost effective and with least side effects. Certain plants have been utilized in the Unani system of medicine for treating psychiatric ailments including depression. The purpose of the study is to evaluate the efficacy and safety of Majoon Najah and Sharbat Ahmed Shahi in the management of Depression on modern scientific parameters.