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Response - NO

Every year chronic wounds affect a large number of population and severely reduce their quality of life. Current statistic indicate that nearly 6 million people suffer due to chronic wounds worldwide. There are very small number of Indian studies available on the epidemiology of chronic wounds. According to journal of wound care, the prevalence rate of chronic wounds in the community was reported as 4.5 per 1000 population whereas that of acute wound was nearly doubled at 10.5 per 1000 population. "The causes for chronic wounds are many, including such systemic conditions atherosclerosis, diabetes mellitus, leprosy and tuberculosis. Other major causes include venous ulcers, pressure sores, trauma, and vasculitis.

As described by Acharya Sushruta, Skin grafting is most useful surgical procedure in present era. Splits thickness skin grafting or STSG is one of the types of skin grafting. But skin grafting may be unsuccessful for numerous reasons. The most common cause for skin graft rejection is hematoma beneath the graft. Similarly, seroma formation may prevent graft adherence to the underlying wound bed, preventing the graft from receiving the necessary nourishment, as detailed above. Movement of the graft or shear forces may also lead to graft failure through disruption of the fragile attachment of the graft to the wound bed. Another common source of failure is a poor recipient site. The wound may have poor vascularity, or the surface contamination may have been too great to allow graft rejection. Infection is also most common cause of graft rejection. According to one study, graft loss secondary to infection was recorded in 31 patients . The microbiological cultures revealed Pseudomonas aeruginosa in 58.1 percentage of the cases, followed by Enterobacter, Staphylococcus aurus, Acinetobacter enterococci.*

In the treatment of all types of wounds and inflammations Yashtimadhu is considered as the drug of choice.

In inflammatory conditions of the eye and various types of Vrana, Chakradutta has advocated the use of this drug. Acharya Charaka has advocated the use of this drug in Vataja and Raktaja diseases at various places. In Sushruta Samhita also described its use in pain in various surgical and medical diseases. Yashtimadhu has Madhura Rasa, Sheeta Virya, Madhura Vipaka and is Vata-Pitta Shamaka. Moreover, studies conducted on modern scientific parameters have proved the healing, anti- ulcer, anti-inflammatory and skin regeneration activity of Yashtimadhu. Sodium glycyrrhizate possessed anti ulcer activity and stimulation of regeneration of skin.