Lutein (L) and zeaxanthin (Z) are two of the widely available carotenoids present in the normal diet of the human and responsible for the bright colors of numerous fruits and vegetables. [1]. R-isomer of Zeaxanthin majorly present in the macula of the retina, though small amounts of S-zeaxanthin isomer are also evident [1, 2]. Humans are unable to synthesize lutein and zeaxanthin isomers; thus, these nutrients are obtained from natural dietary sources or from supplementation [1]. These products can’t be synthesized by the human body but need to be absorbed from the human diet [2]. The activity of these supplements and their serum concentration vary from person to person [1]. The daily supplementation with L+Z was observed to have many clinical benefits including its increase in serum levels and MPOD, improvements in contrast sensitivity and recovery from photo stress [2]. The available clinical evidence needs to be confirmed with the long-term supplementation and its long-term effects. The present study was designed to assess the efficacy and safety of Lutein and Zeaxanthin over four months supplementation. 

Macular pigments promote vision in a number of different ways. Blue light filtration lessens chromatic aberration, which can improve contrast sensitivity and visual field test acuity. The supplementation is observed to elevate the levels of anti-oxidant enzymes significantly by their strong anti-oxidant effect, may reduce the oxidative damage and minimize oxidative stress. This prevents damage to the photoreceptors and retinal pigment epithelial cells. The mechanisms responsible for the action of Lutein and Zeaxanthin by actively quenching singlet oxygen and associated free radicals in the retina, they can further reduce oxidation by filtering blue light to prevent the development of reactive oxygen species, particularly singlet oxygen, in the retina. Also includes prevention of phototoxic damage by absorbing solar radiation, reduction of oxidative stress by scavenging ROS, and antioxidant, antiangiogenic, anti inflammatory properties and naturally either help prevent or reduce the risk of progression of eye diseases like age related macular degeneration and cataracts.