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CTRI Number  CTRI/2025/08/092542 [Registered on: 06/08/2025] Trial Registered Prospectively
Last Modified On: 06/08/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Other 
Public Title of Study   Application of Homoeopathic Repertory in Chronic Urticaria assessed using Urticaria Control Test. 
Scientific Title of Study   Application of Synthesis Repertory (Radar Opus 3.3 - Synthesis Treasure Edition) in treatment of chronic urticaria assessed by Urticaria Control Test - An Experimental Uncontrolled Study. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Yogini Deepak Shirode 
Designation  Post Graduate Student 
Affiliation  Dr M L Dhawale Memorial Homoeopathic Institute, Palghar 
Address  316 Department of Repertory, Dr M L Dhawale Memorial Homoeopathic Institute, Palghar - Boisar Road, Opp. S. T. Workshop, Palghar- 401 404, India. Thane Maharashtra 401404 India

Thane
MAHARASHTRA
401404
India 
Phone  9665288731  
Fax    
Email  yogini.shirode@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Nikunj Jani 
Designation  Associate Professor And Head Of Department 
Affiliation  Dr M L Dhawale Memorial Homoeopathic Institute, Palghar 
Address  315 Department of Repertory, Dr M L Dhawale Memorial Homoeopathic Institute, Palghar - Boisar Road, Opp. S. T. Workshop, Palghar- 401 404, India. Thane Maharashtra 401404 India

Thane
MAHARASHTRA
401404
India 
Phone  9323180460  
Fax    
Email  drnikunj@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Nikunj Jani 
Designation  Associate Professor And Head Of Department 
Affiliation  Dr M L Dhawale Memorial Homoeopathic Institute, Palghar 
Address  315 Department of Repertory, Dr M L Dhawale Memorial Homoeopathic Institute, Palghar - Boisar Road, Opp. S. T. Workshop, Palghar- 401 404, India. Thane Maharashtra 401404 India

Thane
MAHARASHTRA
401404
India 
Phone  9323180460  
Fax    
Email  drnikunj@gmail.com  
 
Source of Monetary or Material Support  
Dr M L Dhawale Memorial Homoeopathic Institute , Palghar - Boisar Road , Opp. S.T. Workshop , Palghar - 401404, Dist. Palghar, Maharshtra, India. 
 
Primary Sponsor  
Name  Dr M L Dhawale Memorial Homoeopathic Institute Palghar 
Address  Dr M L Dhawale Memorial Homoeopathic Institute Palghar Palghar- Boisar Road, Opp. S. T. Workshop, Dist. Palghar, Maharashtra, India, Thane, Maharashtra, 401404 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Anoop Nigwekar  Dr. M. L. Dhawale Memorial Homoeopathic Institute Palghar   315, Department of Repertory, 2nd floor, Dr. M. L. Dhawale Memorial Homoeopathic Institute Palghar Palghar- Boisar Road, Opp. S. T. Workshop, Dist. Palghar, Maharashtra, India, Thane, Maharashtra, 401404.
Thane
MAHARASHTRA 		 9324933032

anoopnigwekar@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Dr. M. L. Dhawale Memorial Homoeopathic Institute Palghar   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: L50||Urticaria,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Indicated Homoeopathic Medicine   Indicated Medicine- Acute/Chronic/Intercurrent, Dose-30/200/1M/10M Potency As Per Indication, Frequency weekly dose , Route Of Administration-Oral,Duration-6Month. 
Comparator Agent  NOT APPLICABLE   NOT APPLICABLE  
 
Inclusion Criteria  
Age From  1.00 Year(s)
Age To  18.00 Year(s)
Gender  Both 
Details  Patients who are diagnosed with chronic urticaria.
Patients of both sexes.
18 year and above age group.
Patients who are taking anti-histaminic drugs for urticaria.
 
 
ExclusionCriteria 
Details  Patients who are taking immunomodulators for urticaria.
Other comorbidities like DM , HTN , Hypothyroidism.
Drug hypersensitivity reactions such as lepra reaction.
Patient having presentation of angioedema with respiratory distress. 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To assess the action of indicated homoeopathic medicine as per Synthesis
Repertory in treatment of Chronic Urticaria assessed through Urticaria
Control Test.
 		 0 month i.e. before treatment , after 3 months of treatment and after 6 months of treatment.
 
 
Secondary Outcome  
Outcome  TimePoints 
To enlist common rubrics & prescribed homoeopathic medicines through
clinical cases of Chronic Urticaria. 		 after 6 months of treatment 
 
Target Sample Size   Total Sample Size="28"
Sample Size from India="28" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   01/09/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  01/09/2025 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
Chronic Urticaria is a mast cell-driven disease that is defined as the occurrence of wheals/hives or both twice in a week for more than 6 weeks due to known or unknown causes. It appears as raised erythematous skin lesions that are pruritic, evascent and worsened up by scratching. 
It affects 15-20% of the population once or more during a lifetime. In around 30% patients of urticaria, attacks often recur for months or years.
As Urticaria comes under hypersensitive reaction of the skin, there is recurrence of symptoms within individuals. Here we have to assess recurrence of symptoms through its intensity and frequency. We can check it through the Urticaria Control Test scale.
The Urticaria Control Test is a questionnaire designed to determine if chronic urticaria is controlled or not and to aid therapeutic decision-making. Homoeopathy is useful in the treatment of Chronic Urticaria and hence I want to take this topic for study to understand the improvement in Chronic Urticaria on the Urticaria Control Test scale through Synthesis Repertory. In the end we will understand the usefulness of Synthesis Repertory in Chronic Urticaria.
 
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