Chronic periodontitis is an inflammatory disease caused by harmful bacteria in the mouth, leading to damage of the tissues supporting the teeth. The condition is common, affecting around 51% of adults globally, with severe cases impacting 19% of the population. Plaque buildup is the main cause, with bacteria like Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum playing a key role. Treatment often includes antibiotics like amoxicillin and metronidazole, but rising antibiotic resistance is a concern. To address this, local drug delivery using nanotechnology has been explored, providing controlled release of antibiotics directly into the affected areas. This method can reduce side effects, improve patient compliance, and enhance treatment effectiveness. The combination of amoxicillin and metronidazole in nanofibers offers a promising solution to combat periodontitis and reduce antibiotic resistance, though more research is needed, especially in the Indian population.

AIM AND OBJECTIVE OF THE STUDY: - The purpose of this study is to evaluate the efficacy of local delivery of amoxicillin and metronidazole nanofibers as an  adjunct to SRP have better clinical and microbiological out come when compared to SRP alone in treatment of  stage II periodontitis patients 

CLINICALPARAMETERS  will be assessed at baseline,1month and 3 months.  Plaque Index Gingival Index Probing Pocket Depth Clinical Attachment Level (CAL)

MICROBIOLOGICAL PARAMETERS are Supra and subgingival Plaque samples will be collected at baseline and at 1 month after

treatment for microbiological assessment.

In the treatment procedure, the test group will first undergo complete  scaling and root planing followed by amoxicillin and metronidazole nanofibers will be placed in the periodontal pockets. The control group will complete ultrasonic scaling and root planing  but no nanofibers will be applied. For the microbial assay, supra- and subgingival plaque samples will be collected from patients diagnosed with stage II periodontitis at baseline and again after 1 month using a sterile curette. These samples will be transported to the microbiology lab for aerobic and anaerobic bacterial culture analysis.