Introduction:

Pulpotomy is a vital pulp therapy that preserves primary teeth by removing infected coronal pulp and applying medicaments to maintain the vitality of the radicular pulp. While Formocresol and MTA are commonly used, they have drawbacks such as cytotoxicity (Formocresol) and long setting time (MTA). Bioactive Glass, known for its biocompatibility and regenerative potential, and Hyaluronic Acid Gel, with its anti-inflammatory and healing properties, may offer a synergistic and biologically favorable alternative. This study will be among the first to evaluate their combined efficacy in pulpotomy for primary molars.

Aim:
To evaluate and compare the clinical and radiographic outcomes of Bioactive Glass with Hyaluronic Acid Gel, MTA, and Formocresol as pulpotomy agents in primary molars at 3, 6, and 12 months.

Materials and Methodology:
An observational study will be conducted on 45 children aged 4–8 years visiting a private dental college in Chennai. The sample size  was calculated using G* power software. Clinical and radiographic assessments will be performed at 3, 6, and 12 months. Data will be analyzed using SPSS software with GEE or Repeated Measures Logistic Regression, McNemar’s test for pairwise comparisons, and significance set at p < 0.05.

Results:
The study will report on the comparative clinical and radiographic success rates of the three pulpotomy agents over time, identifying any statistically significant differences.

Conclusion:
If successful, the combination of Bioactive Glass and Hyaluronic Acid Gel may serve as a superior alternative to traditional pulpotomy agents, promoting safer, regenerative, and more effective vital pulp therapy in pediatric dentistry.