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CTRI Number  CTRI/2025/08/093317 [Registered on: 20/08/2025] Trial Registered Prospectively
Last Modified On: 19/08/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Effectiveness of Kinesio Taping with Neuromuscular Control Exercises in Knee Osteoarthritis 
Scientific Title of Study   Effectiveness of Kinesio Taping Combined with Neuromuscular Control Exercises on Pain and Function in Knee Osteoarthritis: A Randomized Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Md Zahid Hasan 
Designation  Clinical Physiotherapist 
Affiliation  Centre for the Rehabilitation of the Paralysed (CRP) 
Address  Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh
Dhaka, Bangladesh


1343
Other 
Phone  01877790366  
Fax    
Email  zahidhasanrony6666@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Kazi Md Azman Hossain 
Designation  Intern Physiotherapist 
Affiliation  Jashore University of Science and Technology (JUST), Jashore 
Address  Department of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore-7408, Bangladesh
Jashore-7408, Bangladesh


7408
Other 
Phone  01660140833  
Fax    
Email  azmanhossain51@gmail.com  
 
Details of Contact Person
Public Query  
Name  Kazi Md Azman Hossain 
Designation  Intern Physiotherapist 
Affiliation  Jashore University of Science and Technology (JUST), Jashore 
Address  Department of Physiotherapy and Rehabilitation, Jashore University of Science and Technology (JUST), Jashore-7408, Bangladesh
Jashore-7408, Bangladesh


7408
Other 
Phone  01660140833  
Fax    
Email  azmanhossain51@gmail.com  
 
Source of Monetary or Material Support  
Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh  
 
Primary Sponsor  
Name  Md. Zahid Hasan 
Address  Department of Physiotherapy Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh  
Type of Sponsor  Other [self-funded] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     Bangladesh  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Kazi Md Azman Hossain  Centre for the Rehabilitation of the Paralysed (CRP)  Room No: 204, MS-2, Physiotherapy Department, Centre for the Rehabilitation of the Paralysed (CRP), Dhaka, Bangladesh

 		 01660140833

azmanhossain51@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Review Board (IRB) of Institute of Physiotherapy Rehabilitation and Research (the academic institute of BPA)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Control Group: Neuromuscular control exercise   The participants will begin with a 10-minute warm-up that includes ergometer cycling, treadmill, or stepper. The neuromuscular exercises will include quadriceps and hamstrings strengthening, lunging, pelvic tilting, step-ups, squatting, weight shifting, mini-trampoline, limping cross, cloth under foot, kettlebell swings, side-lying jumping jacks, elastic band exercises, and gait training exercises. Each exercise will progress through three levels based on the patients cognition and tolerance throughout the session. All exercises will be performed in 2 sets of 12 repetitions. Each session will conclude with a 10-minute cool-down period that involves walking with focus on alignment and stretching for the lower extremity muscles. Participants will attend a total of 3 sessions per week for 8 weeks, totaling 24 sessions. 
Intervention  Experimental Group: Neuromuscular control exercise with Kinesio taping  The participants will begin with a 10-minute warm-up that includes ergometer cycling, treadmill, or stepper. The neuromuscular exercises will include quadriceps and hamstrings strengthening, lunging, pelvic tilting, step-ups, squatting, weight shifting, mini-trampoline, limping cross, cloth under foot, kettlebell swings, side-lying jumping jacks, elastic band exercises, and gait training exercises. Each exercise will progress through three levels based on the patients cognition and tolerance throughout the session. All exercises will be performed in 2 sets of 12 repetitions. Each session will conclude with a 10-minute cool-down period that involves walking with focus on alignment and stretching for the lower extremity muscles. Kinesio taping will be applied 3 times weekly for 8 weeks. Before application, the skin will be cleaned. Participants will lie on their side with the hip extended and the knee flexed to 60°. An I-shaped kinesio tape will be placed from the origin of the rectus femoris, and a Y-shaped tape will be applied proximal to the superior patellar border. The tape will have no tension at its base, while the section between the anchor and the superior patella will be stretched to about 40%. After 48 hours, the tape will be removed, and each participant will be assessed for skin sensitivity. Participants will attend a total of 3 sessions per week for 8 weeks, totaling 24 sessions.  
 
Inclusion Criteria  
Age From  45.00 Year(s)
Age To  75.00 Year(s)
Gender  Both 
Details  Participants will be included if: patients between the ages of 45 and 75 years, knee OA diagnosis according to the American College of Rheumatology, Kellgren-Lawrence index of II and III, and sign the informed consent form. 
 
ExclusionCriteria 
Details  Participants will be excluded if: systemic inflammatory arthritis, oral steroid treatment in the last 3 months, history of physical therapy or corticosteroid injections at the knee in the last 6 months, previous knee surgery, neurological deficits in the lower extremities, central or peripheral nervous system disease, the cardiopulmonary disease that would prevent exercise, and any contraindication for KT (extensive and severe skin injuries, open wounds with risk of infection, allergic reactions, and pregnancy). 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Pre-numbered or coded identical Containers 
Blinding/Masking   Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded 
Primary Outcome  
Outcome  TimePoints 
Pain intensity on VAS in resting and walking, Pain sensitivity on an algometer, and Function on WOMAC  At baseline, week-8, and week-20 
 
Secondary Outcome  
Outcome  TimePoints 
Muscle strength by Dynamometer, Range of motion by Goniometer, and Functional mobility by the Timed Up and Go test  At baseline, week-8, and week-20 
 
Target Sample Size   Total Sample Size="80"
Sample Size from India="0" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 1 
Date of First Enrollment (India)   04/09/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  04/09/2025 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This randomized controlled trial will compare the effects of neuromuscular control exercises with and without Kinesio taping on pain and function in patients aged 45–75 years with knee osteoarthritis (Kellgren–Lawrence grade II–III). Participants will be randomly allocated to an experimental group receiving exercises plus Kinesio taping or a control group receiving exercises alone, with both groups completing 24 sessions over 8 weeks. Primary outcomes are pain (VAS at rest and walking), pain sensitivity (algometer), and function (WOMAC). Secondary outcomes include muscle strength, range of motion, and functional mobility (Timed Up and Go test), measured at baseline, week 8, and week 20.

 
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