| CTRI Number |
CTRI/2025/08/093066 [Registered on: 14/08/2025] Trial Registered Prospectively |
| Last Modified On: |
12/08/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
To assess how effective Natrum muriaticum is in treating depressive disorder, measured by the 17-item Hamilton Depression Rating Scale. |
|
Scientific Title of Study
|
A prospective study on the effectiveness of natrum muriaticum in managing depressive disorder assesses using hamilton depression rating sacle-17 |
| Trial Acronym |
nil |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Vishnu Priya |
| Designation |
PG |
| Affiliation |
Sarada krishna homoeopathic medical college |
| Address |
Room number 513 4th floor no
Department of psychiatry
Sarada krishna homoeopathic medical college
kulasekharam
kanniyakumari
Tamil nadu 629161
Kulasekharam
Kanniyakumari
TAMIL NADU
629161
India |
| Phone |
8825946342 |
| Fax |
|
| Email |
vp8413363@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr P R Subi |
| Designation |
Professor |
| Affiliation |
Sarada krishna homoeopathic medical college |
| Address |
Room number 513 4th floor
Department of pschyiatry
Sarada krishna homoeopathic medical college
kulasekharam
kanniyakumari
Tamil nadu 629161
Kulasekharam
Kanniyakumari
TAMIL NADU
629 161
India |
| Phone |
09486863644 |
| Fax |
|
| Email |
drsubinair@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr P R Subi |
| Designation |
Professor |
| Affiliation |
Sarada krishna homoeopathic medical college |
| Address |
Room number 513 4th floor
Department of pschyiatry
Sarada krishna homoeopathic medical college
kulasekharam
kanniyakumari
Tamil nadu 629161
Kulasekharam
Kanniyakumari
TAMIL NADU
629 161
India |
| Phone |
09486863644 |
| Fax |
|
| Email |
drsubinair@gmail.com |
|
|
Source of Monetary or Material Support
|
| Institution- Sarada krishna homoeopathic medical college, kulasekharam kanniyakumari Tamil nadu 629161 |
|
|
Primary Sponsor
|
| Name |
Post graduated research funded by sarada krishna homoeopathic medical college |
| Address |
Sarada krishna homoeopathic medical college
Kulasekharam
kanniyakumari
tamilnadu 629161 |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Vishnu priya K |
Sarada krishna homoeopathic medical college |
Room number 513
4th floor
Department of psychiatry
Sarada krishna homoeopathic medical college
kulasekharam
kanniyakumari
Kanniyakumari
TAMIL NADU |
9486863644
drsubinair@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional ethics committe |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: F32||Major depressive disorder, singleepisode, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Natrum muriaticum |
It is a commonly used remedy derived from ordinary table salt (NaCl), which is also called sodium chloride or common salt. This remedy has been tested and studied by homoeopathic pioneers such as Dr. Hahnemann, Dr. W.H. Schussler, and the Austrian Society of Provers. It is considered a "polychrest" remedy, meaning it can treat a wide range of symptoms. Natrum Muriaticum is known for its deep-acting and long-lasting
effects. |
| Comparator Agent |
NIL |
NIL |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
65.00 Year(s) |
| Gender |
Both |
| Details |
Patients diagnosed with depressive disorder according to ICD-10 criteria.
Age group - 18 to 65 years.
Both genders |
|
| ExclusionCriteria |
| Details |
Patients with severe mental illness, currently on antidepressants or other
homoeopathic medicines.
Pregnant and lactation women
Patients under other psychiatric medications. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
Assessment is done for every 2 weeks medication and the cases is followed up period
of 6 months |
6months |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Assessment is done for every 2 weeks medication and the cases is followed up period
of 6 months |
6 months |
|
|
Target Sample Size
|
Total Sample Size="34"
Sample Size from India="34"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 3/ Phase 4 |
|
Date of First Enrollment (India)
|
30/08/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="6"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
INTRODUCTION: Depressive disorder is one of the most prevalent mental health conditions worldwide, characterized by persistent sadness, loss of interest, and impaired daily functioning. According to the World Health Organization (WHO), depression is a leading cause of disability globally, significantly impacting individuals’ quality of life, productivity, and overall well-being. Natrum muriaticum is frequently prescribed based on the principle of individualization, especially in cases presenting with classical depressive symptoms like grief, sadness, and emotional suppression. The Hamilton Depression Rating Scale - 17 (HAM-D-17) is a validated and widely used clinician-administered questionnaire that assesses the severity of depression. It provides a structured method to objectively evaluate the effectiveness of interventions aimed at reducing depressive symptoms. PROCEDURE: Patients diagnosed with depressive disorder, as per the ICD-10 criteria, will be assessed using the HAM-D-17 scale. After detailed case taking, Natrum muriaticum will be prescribed based on symptom similarity. At each follow-up visit, the assessment will be repeated using the HAM-D-17 scale. OUTCOME : The effectiveness of Natrum muriaticum will be assessed based on improvement in the Depressive Disorder HAM-D - 17 Scale. |