A Psychoneuroendocrine disorder of unknown etiology, Premenstrual syndrome (PMS) is characterized by the cyclical occurrence of several symptoms in the final seven to ten days of the menstrual cycle. According to the American College of Obstetricians and Gynecologists’ (ACOG) criteria, it is diagnosed as Pre-Menstrual Syndrome (PMS) when symptoms significantly interfere with day-to-day functioning. About 47.8% of women of reproductive age worldwide suffer from Pre-Menstrual Syndrome. Another known risk factor for postpartum depression is Pre-Menstrual Syndrome. Hormonal changes, stress, diet, and neurotransmitter imbalances—especially those involving aberrant serotonin activity and altered neurosteroid metabolism—are all contributing factors. However, women with and without PMS may have the same absolute hormone levels. The severity of PMS varies from person to person; 30.6% report mild symptoms, 13.6% report moderate symptoms, and 8.1% report severe distress. Women with regular cycles tend to report more symptoms than those with irregular periods. Even though PMS is very common and has a big influence on public health, the Global Burden of Disease (GBD) model predicts that each woman with severe PMS will be disabled for about 3.835 years. Despite the use of vitamin/mineral supplements (62%), exercise (59%), natural progesterone (51%), dietary changes (44%), antidepressants (15%), and anxiolytics (10%), only about one-third of women say they are satisfied with the treatments they have received. In light of these restrictions, the purpose of this clinical study is to assess how well constitutional  homeopathic treatment can control Pre-Menstrual Syndrome and enhance quality of life. Pre-Menstrual Syndrome symptoms, each patient’s mental, emotional, and physical constitution will be examined. Based on the sum of their symptoms, a suitable homeopathic remedy will be selected and medications will be given on Day 18 of the typical 28-day cycle, calculated based on longer and shorter cycles accordingly. The Premenstrual Syndrome Assessment Scale (PMSS) will be used to evaluate progress every month to assess the reduction in the Pre-Menstrual Symptoms.