| CTRI Number |
CTRI/2025/08/093332 [Registered on: 20/08/2025] Trial Registered Prospectively |
| Last Modified On: |
14/08/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Homeopathy |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
Homoeopathic management of thyroid disorders in females |
|
Scientific Title of Study
|
Evaluating the role of “Ailments from grief” as an Eliminating Rubric in
managing of Hashimotos Thyroiditis using Murphy’s Repertory |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr SUSHMITHA SAJAN |
| Designation |
POST GRADUATE |
| Affiliation |
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
| Address |
ROOM NUMBER 301
SECOND FLOOR
DEPARTMENT OF HOMOEOPATHIC REPERTORY AND CASE TAKING
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
KULASEKHARAM
KANNIYAKUMARI DISTRICT
TAMIL NADU
Kanniyakumari TAMIL NADU 629161 India |
| Phone |
8903814037 |
| Fax |
|
| Email |
sajansushmitha22@gmail.com |
|
Details of Contact Person Scientific Query
|
| Name |
Dr V SATHISH KUMAR |
| Designation |
HOD AND PROFESSOR |
| Affiliation |
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
| Address |
ROOM NUMBER 301
SECOND FLOOR
DEPARTMENT OF HOMOEOPATHIC REPERTORY AND CASE TAKING
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
KULASEKHARAM
KANNIYAKUMARI DISTRICT
TAMIL NADU
Kanniyakumari TAMIL NADU 629161 India |
| Phone |
9443558483 |
| Fax |
|
| Email |
hodcr@skhmc.org |
|
Details of Contact Person Public Query
|
| Name |
Dr V SATHISH KUMAR |
| Designation |
HOD AND PROFESSOR |
| Affiliation |
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
| Address |
ROOM NUMBER 301
SECOND FLOOR
DEPARTMENT OF HOMOEOPATHIC REPERTORY AND CASE TAKING
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
KULASEKHARAM
KANNIYAKUMARI DISTRICT
TAMIL NADU
Kanniyakumari TAMIL NADU 629161 India |
| Phone |
9443558483 |
| Fax |
|
| Email |
hodcr@skhmc.org |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
POST GRADUATE DISSERTATION SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
| Address |
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
KULASEKHARAM
KANNIYAKUMARI DISTRICT
TAMIL NADU
629161 |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr V SATHISH KUMAR |
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL |
ROOM NUMBER 103
GROUND FLOOR
SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE AND HOSPITAL
KULASEKHARAM
KANNIYAKUMARI DISTRICT
TAMIL NADU
629161 Kanniyakumari TAMIL NADU |
09443558483
hodcr@skhmc.org |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICS COMMITTEE |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: E063||Autoimmune thyroiditis, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
HOMOEOPATHIC MEDICINES |
MEDICINES SELECTED FROM AILMENTS FROM GRIEF RUBRIC IN MURPHY REPERTORY WILL BE REPEATED WEEKLY IN A SINGLE DOSE FOR 6 MONTHS.MEDICINES WILL BE ORALLY ADMINISTERED IN ONE DOSE AT A TIME |
| Comparator Agent |
NIL |
NIL |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
50.00 Year(s) |
| Gender |
Female |
| Details |
Cases with Hashimotos thyroiditis associated with grief
Includes cases of Hashimotos thyroiditis with altered thyroid function Levels and anti-thyroglobulin levels.
|
|
| ExclusionCriteria |
| Details |
Patients with any other pathology like diabetes mellitus, hypertension
Patients under hormonal therapy
Patients under non-steroidal inflammatory drugs
Patients undergone recent surgery with medication
Patients under any psychiatric treatment
Other inflammatory conditions & Malignant lesions will be excluded
|
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Not Applicable |
|
Primary Outcome
|
| Outcome |
TimePoints |
| The efficacy of Homoeopathic medicines in reducing the thyroid function level and Anti-thyroglobulin antibody level in Hashimoto’s thyroiditis will be proved before and after treatment |
Once in 6 months blood parameters will be checked |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| The improvement of grief symptoms will be assessed before and after treatment with grief assessment scale which will reveal the efficacy of homoeopathic medicine selected from Ailment from grief rubric Murphy Repertory |
Once in 6 months grief assesment will be done |
|
|
Target Sample Size
|
Total Sample Size="34" Sample Size from India="34"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 3/ Phase 4 |
|
Date of First Enrollment (India)
|
30/08/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1" Months="0" Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Hashimotos thyroiditis is one of the common autoimmune disorders, in this condition the immune system of one’s own attack their thyroid gland which leads to hypothyroidism and associated symptoms. This condition not only affects physical health but also has significant emotional and psychological impact. It’s known that the early life stress, such as emotional neglect or abuse, has been a risk factor for developing autoimmune thyroid disorders. The unresolved grief or trauma from early life experiences may contribute to the onset of Hashimoto’s thyroiditis later in life. As Homoeopathic principles and treatments are based on holistic approach it’s very important to cover all the mental and emotional aspects of the patient. There are various repertories that have ailment from grief rubrics but Homeopathic Medical Repertory by Robin Murphy, contains every detail from all the existing repertories & upgradation from various sources, it contains 34 rubrics related to “Ailments from grief” which covers a large group of remedies. My aim is to evaluate the effectiveness of homoeopathic treatment in Hashimoto’s thyroiditis case by using ailment from grief as an eliminating rubric with Murphy repertory. A sample of 34 cases with Hashimoto’s thyroiditis having ailment from grief will be selected from the OPD, and peripheral centres of Sarada Krishna Homoeopathic Medical College and Hospital and will be randomly assigned in the study. The sample size is 34 Cases and the period of study is 1 Year. The Expected duration of the subject participation is 6 Months. The outcome is to find the improvement of Hashimoto’s thyroiditis symptoms, blood parameters (thyroid function test, antiglobulin antibody) and grief symptoms by administering homoeopathic medicine prescribed using “Ailment from grief” rubric as an eliminating rubric. Pre and post treatment assessment of blood parameters, grief symptoms will be recorded. The Cases will be evaluated for age, sex, occupation, symptoms presented, values of thyroid function test antiglobulin antibody and grief assessment scale will be considered for statistical analysis and to derive the result, thereby validating the study. |