Dental implant success largely depends on rapid and stable osseointegration between the implant surface and surrounding bone. Various biological modifications have been explored to enhance early implant healing and implant stability. Injectable platelet-rich fibrin (i-PRF) is an autologous platelet concentrate rich in platelets, leukocytes, and growth factors that promote angiogenesis, osteogenesis, and tissue regeneration. The i-prf is prepared by drawing 10 ml of patient’s blood and centifuging at 700rpm for 3 minutes

Coating dental implants with i-PRF prior to placement may create a biologically active fibrin matrix on the implant surface that facilitates enhanced cellular adhesion, growth factor release, and early bone formation at the implant–bone interface. This may improve early implant stability and potentially enhance the osseointegration process.

The present study will be conducted as a randomized controlled clinical trial involving 20 participants requiring dental implant placement, who will be randomly allocated into two groups (10 participants in each group). The test group will receive implants coated with i-PRF prior to placement, while the control group will receive implants placed using the conventional protocol without i-PRF coating.

The primary outcome measure will be implant stability quotient (ISQ) assessed using resonance frequency analysis at baseline (week 0), week 1, week 6, and week 12 following implant placement. The secondary outcome measure will be the width of keratinized gingiva around the implant site, measured clinically by applying iodine solution and meausred in millimeters using a periodontal probe.

The inclusion criteria includes Patients with edentulous region in mandibular posterior posterior region. 

Patient who want Implant processes in their edentulous region.

Patient with adequate height and width in posterior region for Implant placement .

systematically healthy  patients .

patients with the ability to maintain oral hygiene  .

patients who are willing for voluntary participation and have signed inform consent

the exclusion criteria includes Patients who have received periodontal flap or regenerative therapy within the past one year

Patients with para functional habits and Bruxism

Patients who demonstrate poor hygiene maintenance

Patients with known systemic diseases, metabolic disorders

Patients under medication known to affect the outcome of the periodontic therapy

Patients under any medication that alters bone morphology

Patients using any form of tobacco

Patients who are alcoholics

Pregnant and lactating women

Patient with known allergies

Patients undergoing radiation therapy or history of radiation within the last two years

The results of this study aim to evaluate whether i-PRF coating of implant surfaces can improve early implant stability and peri-implant soft tissue parameters, thereby contributing to improved clinical outcomes in implant therapy