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CTRI Number  CTRI/2025/08/092815 [Registered on: 11/08/2025] Trial Registered Prospectively
Last Modified On: 11/08/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Managing Knee Osteoarthritis in Women with Individualized Homeopathic treatment with medicines selected by using Boger Boenninghausens Repertory 
Scientific Title of Study   Efficacy of Individualized Homoeopathic Treatment using Boger-Boenninghausen’s Repertory in Females with Knee Osteoarthritis: A Randomized Controlled Trial. 
Trial Acronym  Nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Anushya A 
Designation  Post Graduate 
Affiliation  Sarada Krishna Homoeopathic Medical College and Hospital  
Address  Room No 301 2nd Floor college building Department of Homoeopathic Repertory and Case Taking Sarada Krishna Homoeopathic Medical College and Hospital Kulasekharam Kanyakumari

Kanniyakumari
TAMIL NADU
629161
India 
Phone  8939029202  
Fax    
Email  anush1793@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Suman Sankar AS MDHom PhD 
Designation  Professor 
Affiliation  Sarada Krishna Homoeopathic Medical College and Hospital  
Address  Room No 301 2nd Floor Department Of Homoeopathic Repertory and Case Taking Sarada Krishna Homoeopathic Medical College and Hospital Kulasekharam Kanyakumari

Kanniyakumari
TAMIL NADU
629161
India 
Phone  9443500675  
Fax    
Email  dissert02@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Suman Sankar AS MDHom PhD 
Designation  Professor 
Affiliation  Sarada Krishna Homoeopathic Medical College and Hospital  
Address  Room No 301 2nd Floor college building Department Of Homoeopathic Repertory and Case Taking Sarada Krishna Homoeopathic Medical College and Hospital Kulasekharam Kanyakumari

Kanniyakumari
TAMIL NADU
629161
India 
Phone  9443500675  
Fax    
Email  dissert02@gmail.com  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Dr Anushya A Sarada Krishna Homoeopathic Medical College and Hospital  
Address  Room No 107 Ground floor Sarada Krishna Homoeopathic Medical College and Hospital Kulasekharam, Kaniyakumari district 629 161  
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Anushya A  Sarada Krishna Homoeopathic Medical College and Hospital   Room No 107 Ground Floor Sarada Krishna Homoeopathic Medical College and Hospital Kulasekharam Kanyakumari
Kanniyakumari
TAMIL NADU 
08939029202

anush1793@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
INSTITUTIONAL ETHICS COMMITTEE SARADA KRISHNA HOMOEOPATHIC MEDICAL COLLEGE   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Calcarea Flourica 6x   Control group Receives Calcarea Flourica 6x 2 pills in the morning and 2 pills at night daily 
Intervention  Individualized Homeopathic Medicines  Study Group receives homeopathic treatment selected through repertorisation based on individual symptoms The medicine will be administered daily once every morning after food orally 30th potency 2 globules or as required based on the susceptibility of the patient The patients will be followed every 14 days or as required and follow up treatment will be based on the symptom changes either SL or higher potency or change of medicine based on the repertorization results  
 
Inclusion Criteria  
Age From  35.00 Year(s)
Age To  70.00 Year(s)
Gender  Female 
Details  Patients with complaints of osteoarthritis of knee 
 
ExclusionCriteria 
Details  Patients with arthritic chronic diseases other than osteoarthritis and surgical complications
Male patients
Patients with severe disability of osteoarthritis of knee
 
 
Method of Generating Random Sequence   Random Number Table 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Effectiveness of individualized homoeopathic remedies in managing knee osteoarthritis in females as assessed by changes in clinical symptoms
Reduction in pain intensity and improvement in joint functionality measured using validated scale such as WOMAC pain scale and VAS
Improvement in quality of life evaluated through patient reported outcome measures
 
Reduction in pain intensity will be assessed for 2 MONTHS for once in 15 days
end of 2 months changes in pain will be assessed


 
 
Secondary Outcome  
Outcome  TimePoints 
Identification of frequently used rubrics in the treatment of knee osteoarthritis as per Boger Boenninghausens Characteristics and Repertory BBCR
Analysis of the most commonly selected remedies based on repertorization results for knee osteoarthritis cases
 
2 MONTHS 
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Osteoarthritis is the most prevalent type of musculoskeletal disorder globally and is the leading cause of chronic pain and disability in adults A survey revealed that significantly higher prevalence of arthritis in the rural 17 percentage in adult compared with the urban in tamil nadu The prevalence of osteoarthritis in kanyakumari district is 115000 adult population and women are more affected 

Aims to assess the clinical efficacy of individualized homoeopathic treatment prescribed according to boger boenninghausens characteristics and repertory BBCR in comparison to calcarea fluorica 6x in the management of knee OA in females 

Objectives compare changes in pain stiffness and physical function using the womac scale between both groups over 8 weeks evaluate patient satisfaction and quality of life during the treatment period and to identify commonly used rubrics and remedies selected through BBCR in knee OA cases 

Methodology two group comparative randomized control study design sampling  random sampling 

Study group medicine selected using BBCR and control group calc flour 6x Random selection of 40 females presenting with OA from the opd ipd oa speciality clinic and phc of skhmc are taken Remedies will be prescribed based on repertorisation using BBCR Follow up assessment will be done twice a month

Outcome assessment the changes before and after will be subjected to statistical analysis and presented on the basis of womac pain scale

Primary outcomes effectiveness of individualized homoeopathic remedies in managing knee OA in females as assessed by changes in clinical symptoms reduction in pain intensity and improvement in joint functionality measured using validated scale such as womac pain scale improvement in quality of life evaluated through patient reported outcome measures

Secondary outcomes identification of frequently used rubrics in the treatment of knee OA as per BBCR analysis of the most commonly selected remedies based on repertorization results for knee OA cases

 
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