Eczema is a skin condition that extends beyond physical symptoms, causing emotional distress, social stigma, and impacts on daily life, including career and personal relationships. The prevalence of Eczema ranged from 0.98% to 9.2% in studies including paediatric and adult patients. The cost of medications was reported to be the major contributor to the economic burden associated with Eczema. This prospective study aims to evaluate the effectiveness of individualized homoeopathic treatment on the quality of life and symptom severity in patients diagnosed with Eczema. A total of 28 patients, aged between 16 to 65 years and of both sexes, will be enrolled from the Outpatient Department (OPD), Inpatient Department (IPD), and affiliated rural health centres of Sarada Krishna Homoeopathic Medical College. Each patient will undergo a thorough case-taking process, and homoeopathic medicines will be prescribed based on the totality of symptoms. The primary outcome measures for the study include the Dermatology Life Quality Index (DLQI), a validated tool to assess the impact of skin diseases on patients’ daily lives, and the Eczema Area Severity Index (EASI), which is employed to objectively measure the severity of eczema symptoms. The pre-assessment is conducted during the initial visit, followed by regular follow-up every 14 days. The cases are being observed over a period of 6 months. Post-assessments will be done at the end of 3 months and again at the end of 6 months using the DLQI and EASI. All relevant clinical data and patient responses will be systematically documented throughout the study. This study aims to provide observational evidence on the role of individualised homoeopathic treatment in managing eczema and improving patients’ quality of life, thereby contributing to integrative dermatological care. The outcomes may support further research into the potential benefits of homoeopathy in chronic dermatological conditions.