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CTRI Number  CTRI/2025/08/093483 [Registered on: 22/08/2025] Trial Registered Prospectively
Last Modified On: 17/02/2026
Post Graduate Thesis  No 
Type of Trial  Observational 
Type of Study   Diagnostic 
Study Design  Other 
Public Title of Study   A study in people who have tremors using computer-based video analysis to detect and differentiate Parkinson’s, Essential, and Cerebellar tremors. 
Scientific Title of Study   Analysis of Pose-Driven Computer Vision Algorithm for Tremor Differentiation  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr K A Sunitha  
Designation  Assoc Prof HoD 
Affiliation  SRM University AP 
Address  SRM UNIVERSITY NEERUKONDA MANGALAGIRI GUNTUR DT

Guntur
ANDHRA PRADESH
522240
India 
Phone  9600086770  
Fax    
Email  sunitha.ka@srmap.edu.in  
 
Details of Contact Person
Scientific Query  
Name  Dr K A Sunitha  
Designation  Assoc Prof HoD 
Affiliation  SRM University AP 
Address  SRM UNIVERSITY NEERUKONDA MANGALAGIRI GUNTUR DT


ANDHRA PRADESH
522240
India 
Phone  9600086770  
Fax    
Email  sunitha.ka@srmap.edu.in  
 
Details of Contact Person
Public Query  
Name  Dr K A Sunitha  
Designation  Assoc Prof HoD 
Affiliation  SRM University AP 
Address  SRM UNIVERSITY NEERUKONDA MANGALAGIRI GUNTUR DT


ANDHRA PRADESH
522240
India 
Phone  9600086770  
Fax    
Email  sunitha.ka@srmap.edu.in  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  SRM UNIVERSITY 
Address  SRM UNIVERSITY AP NEERU KONDA MANGALAGIRI GUNTUR DT 
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
AIIMS MANGALAGIRI  MANGALAGIRI GUNTUR DT 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Alex Rebello  AIIMS  DEPARTMENT OF NEUROLOGY OPB BLOCK ROOM NO.211 MANGALAGIRI GUNTUR DT
Guntur
ANDHRA PRADESH 		 8110087168

dralexrebello@aiimsmangalagiri.edu.in 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
AIIMS Mangalagiri  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G20||Parkinsons disease,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Not Applicable  NIL 
Comparator Agent  Not Applicable  NIL 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  1.Adults aged above 18 years with a confirmed diagnosis of Rest Tremor, Essential Tremor, or Cerebellar Tremor.
2.Patients willing to provide written informed consent.
3.Ability to maintain predefined poses (e.g., rest, extended arm, intentional movement) during data collection.  
 
ExclusionCriteria 
Details  1.Patients with cognitive impairments preventing compliance.
2.Patients with other movement disorders not related to tremor.
3.Patients unwilling or unable to provide informed consent.  
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
The primary outcome is the accurate identification of tremor types using the developed computer vision system, validated by healthcare experts.  Outcome will be assessed at Baseline (Day 0), Week 4, and Week 8, using the computer vision system with concurrent expert validation at each visit.
 
 
Secondary Outcome  
Outcome  TimePoints 
This study aims to differentiate between rest tremor, essential tremor, & cerebellar tremor, each associated with distinct neurological pathways & clinical characteristics  Baseline (Day 0), Week 2, Week 4, & Week 8 
 
Target Sample Size   Total Sample Size="75"
Sample Size from India="75" 
Final Enrollment numbers achieved (Total)= "75"
Final Enrollment numbers achieved (India)="75" 
Phase of Trial   N/A 
Date of First Enrollment (India)   02/09/2025 
Date of Study Completion (India) 17/02/2026 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="3"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  		 Completed 
Recruitment Status of Trial (India)  Completed 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

This pilot study aims to evaluate the efficacy of a computer vision-based system developed to differentiate between rest tremor, essential tremor, and cerebellar tremor. The study will involve a total of 75 subjects, with 25 participants in each tremor category, selected from various age groups above 18 years. Each subject will be independently evaluated using the developed computer vision system. The system utilizes video recordings of the patients’ hand and limb movements, focusing on capturing tremor activity during standardized postures. These include the rest pose (with hands placed on the knees while seated), the stretched hand pose (arms extended parallel to the ground), and intentional movement tasks (such as finger-to-nose or object-reaching movements). Each participant is required to sit for a maximum of 10 minutes to complete the evaluation individually. The recorded videos are processed using the developed computer vision algorithms to extract key motion features such as tremor frequency and trajectory patterns. These features are then analyzed to differentiate between Parkinsonian tremor, essential tremor, and cerebellar tremor.

 
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