Psoriasis is a common genetically determined inflammatory skin disorder of unknown cause which in its most usual form is characterized by well demarcated raised red scaling patches that preferentially localize to the extensor surfaces

Most common sites of involvement are scalp elbow and knees hands feet trunk and nails Palmoplantar Psoriasis can occur alone on palms and soles or along with involvement of the other areas

It affects around 2 to 3 percent of the world population In India it affects about 0.8 to 8 percent population Among the types of Psoriasis prevalence of Palmoplantar Psoriasis is about 2.8 to 40.9 percent in psoriatic patients Psoriasis usually affects the age group between 15 to 50 years and less common below 10 years of age

In conventional medicine mild psoriasis is treated by topical application of emollients topical corticosteroids calcipotriene tazarotene topical tars anthralin and keratolytics

Mild psoriasis requires phototherapy or systemic therapy in combination with topical agents or phototherapy Systemic therapy includes Methotrexate Photo chemotherapy Narrow band UVB therapy Retinoids and Cyclosporine Biologics used for moderate to severe Psoriasis include Etanercept Alefacept Efalizumab Infliximab and Adalimumab And it is reserved for the patient who fail or cannot complete treatment with topical or systemic medications But these drugs exert adverse effects such as nausea dryness of mouth fatigue alopecia nephrotoxicity hepatotoxicity teratogenicity hypertension drug interaction