1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [divyassvlrd@gmail.com].
   


6. For how long will this data be available start date provided 13-11-2026 and end date provided 13-11-2031?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

AIM

To evaluate the efficacy of Homoeopathic treatment versus standard iron preparations in improving iron deficiency anemia and its symptoms using a randomized controlled trial approach.

BACK GROUND 

Iron deficiency anemia (IDA) is a prevalent global health issue among young adults, impacting cognitive function, physical performance, and overall well-being. Homoeopathy offers an individualized approach that may enhance iron absorption and address underlying causes through remedies like Ferrum metallicum and Ferrum phosphoricum. By stimulating the body’s natural healing mechanisms, Homoeopathy presents a potentially gentler alternative to conventional iron therapy.

JUSTIFICATION

While case studies suggest that individualized homoeopathic remedies may improve hemoglobin levels and reduce anemia symptoms, robust randomized trials are needed to establish comparative efficacy. Homoeopathy’s favorable tolerability profile and potential to enhance iron metabolism offer a promising alternative for individuals who experience side effects from conventional iron therapy.

HYPOTHESIS: 

  NULL HYPOTHESIS (Ho): Homoeopathic treatment results in significantly lower improvements compared to Standard iron therapy in managing iron deficiency anemia among young adults.

 ALTERNATIVE HYPOTHESIS (H₁): Homoeopathic treatment provides  comparable improvements in iron deficiency anemia outcomes among young adults compared to Standard iron therapy.

METHODOLOGY

This is a prospective, double-blind, randomized controlled trial involving 60 young adults (aged 20–24 years) with confirmed iron deficiency anemia (serum ferritin <15 ng/mL). Participants will be randomly assigned to two groups:

Arm A (Homoeopathic group) will receive individualized Homoeopathic remedies (30C or 200C) weekly.

Arm B (Control group) will receive standard iron supplementation (100–200 mg daily).

Both groups will follow a balanced diet (based on WHO calorie guidelines) and maintain daily diet charts to monitor intake. No additional iron-rich foods will be introduced. 

For IDA due to helminthic infestation, the control group will receive standard treatment; the intervention group will receive individualized Homoeopathic prescriptions based on totality of symptoms.

Follow-up assessments will occur at 3 and 6 months, with an additional 3-month post-treatment observation. Adverse events will be reported to the study guide and ethics committee. Continued care will be provided at White Memorial Homoeo Medical College or White Mission Hospital, Attoor.