Recurrent aphthous stomatitis are
common painful oral ulcers categorized as minor major herpetiform. Etiology
involves stress immunologic hormonal hereditary environmental factors Treatment includes Honey-Turmeric mix cap. Pre-pro
biotic Topical Triamcinolone
Study Aims &
Objectives
To compare efficacy of Oral probiotics Topical
steroids Topical application of turmeric powder with honey in management of
recurrent aphthous ulcer
The objectives are To assess the efficacy of 3
treatment modalities in pain, burning sensation and reduction in size To evaluate the most effective
treatment plan for healing of recurrent
aphthous ulcer
Methodology
·
Study Location Department of Oral Medicine and
Radiology Government Dental College and Hospital Ahmedabad
·
Probable estimated time to complete the study 2 years
·
Sample size with calculation formula Statistician
Certificate is mandatory Total
138 patients 46 in each group analysis
done using A priori
·
Inclusion and Exclusion Criteria
INCLUSION
CRITERIA Subjects
of both gender attending daily routine OPD Subjects
suffering from recurrent major & minor aphthous ulcer Subjects
willing to participate & giving informed consent Patients
not taking any other medications
EXCLUSION
CRITERIA
·
Recurrent aphthous ulcer in an
inaccessible area
·
Pregnant or lactating women
·
Patient already undergoing treatment
for ulcer
·
Ulcer associated with other oro mucosal lesion or ulcer
·
Patients with systemic diseases like
Bechet syndrome Sweet syndrome periodic fever adenitis pharyngitis aphthous
ulcer PFAPA Reiter syndrome Crohn’s disease Gluten sensitive enteropathy
etc
·
Subjects hypersensitive to agents
used in this trial
·
Armamentarium and Methodology
·
Armamentarium
Diagnostic
instruments
Williams
Graduated Probe
Informed consent the study is explained
followed by which an informed consent is taken from the patient
All patients were given dietary instructions to avoid
spicy food & encouraging a bland diet
The patient would be assessed on various parameters like
1.
Pain or Burning sensation
2.
Lesion size
3.
Number of lesion
4.
Difficulty in chewing or speaking
1.)
Pain The intensity of
pain was determined by visual analogue scale VAS
From 1to 10
0
Absent
1to 3 Mild
4to7 Moderate
8to10 Severe
1
Burning sensation:
Burning sensation was recorded using VAS as follows
0to3Mild Burning sensation
4to7Moderate Burning sensation
8to10 severe Burning sensation
Size of ulcer The size
of ulcer was measured using Williams graduated probe
Number of ulcer
Difficulty in chewing or speaking yes or no
Group 1 A monotherapy of microbiome pre probiotic orally
Participants were
advised to take capsule thrice daily with food for a week.
Group 2 Topical application of mixture of turmeric
powder and honey
Participants were
advised to freshly prepare (at the time of every application) mixture of ¼ tea
spoon of turmeric powder & ¼ tea spoon of honey, apply thrice daily over and around 1 cm of each ulcer with cotton applicator tip & advised not to
eat or drink or spit for next 30 mins.
Also instructed to use
clean utensils while preparing mixture & apply mixture after gargling.
Group 3 Topical application of 0.1% triamcinolone
acetonide
Participants
were advised to apply thrice daily over and around 1 cm of each ulcer by
cotton applicator tip & advised not to eat or drink for next 30 mins
·
Observational Parameters VAS score for pain burning
sensation and measuring size of ulcer on 0 4 & 7 day
·
Concluding Remarks or expected outcomes
The results will compare between the efficacy and rapidity to response of all the three different treatment modalities
resulting in reduction in size of ulcer pain and in burning sensation with
reduction in frequency of recurrence. |