| CTRI Number |
CTRI/2025/10/096419 [Registered on: 23/10/2025] Trial Registered Prospectively |
| Last Modified On: |
22/10/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Single Arm Study |
|
Public Title of Study
|
How Exercise Helps Improve Memory in Middle-Aged Adults |
|
Scientific Title of Study
|
Effect of Physical Activity on Visuospatial Working Memory in middle-aged adults |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Prof Dr Nidhi Sharma |
| Designation |
Professor |
| Affiliation |
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation |
| Address |
Room No. 6, General OPD, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana
Ambala
HARYANA
133203
India |
| Phone |
9760835605 |
| Fax |
|
| Email |
sharma.nidhi.physio@mmumullana.org |
|
Details of Contact Person
Scientific Query
|
| Name |
Abhishek Aaryan |
| Designation |
Postgraduate Student |
| Affiliation |
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation |
| Address |
Room No. 6, General OPD, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana
Ambala
HARYANA
133203
India |
| Phone |
6201025038 |
| Fax |
|
| Email |
abhishekaaryan2000@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Abhishek Aaryan |
| Designation |
Postgraduate Student |
| Affiliation |
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation |
| Address |
Room No. 6, General OPD, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar Deemed to be University, Mullana, Ambala, Haryana
Ambala
HARYANA
133203
India |
| Phone |
6201025038 |
| Fax |
|
| Email |
abhishekaaryan2000@gmail.com |
|
|
Source of Monetary or Material Support
|
| Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133203 |
|
|
Primary Sponsor
|
| Name |
Abhishek Aaryan |
| Address |
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133203 |
| Type of Sponsor |
Other [Self] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Abhishek Aaryan |
Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation |
Room No. 6, General OPD, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be university), Mullana, Ambala, Haryana, 133203
Ambala
HARYANA |
6201025038
abhishekaaryan2000@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| INSTITUTIONAL ETHICAL COMMITTEE OF MAHARISHI MARKANDESHWAR INSTITUTE OF MEDICAL SCIENCE AND RESEARCH MULLANA, AMBALA |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Visuospatial Working Memory |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
NIL |
NIL |
| Intervention |
Warm up, High Intensity Functional Training, Relaxing exercises |
Each session began with a 10-minute dynamic warm-up (High Kness, Butt kicks, Arm and Hip circle, Lunges with a twist) to prepare participants’ muscles and joints for high-intensity activity. The core of the workout consisted of a 20-minute circuit of alternating exercises: 30 seconds of anaerobic, high-intensity movements such as sprints and jumps, followed by 30 seconds of bodyweight or free-weight resistance exercises like push-ups, squats, and presses. This pattern was repeated, with exercises gradually increasing in difficulty by incorporating free weights after starting with bodyweight-only movements.The session concluded with a 5-minute cool-down stretch to aid muscle recovery. HIFT program was conducted three times per week for 4 weeks throughout the study |
|
|
Inclusion Criteria
|
| Age From |
35.00 Year(s) |
| Age To |
44.00 Year(s) |
| Gender |
Both |
| Details |
Subjects with age thirty-five to fourty-five years
Both Male and Female gender
Mini-Mental State Examination greater than twenty-four |
|
| ExclusionCriteria |
| Details |
Any clinical symptoms or indicators of cardiovascular disease.
Intake of any psychiatric drugs or medications that might impact cardiovascular or cognitive function.
Individuals who had surgery within the last six months.
Those not having normal vision or vision not corrected through aids. |
|
|
Method of Generating Random Sequence
|
Not Applicable |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Participant Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| Corsi Block Tapping Task |
Baseline, Post-intervention (4 weeks) |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| nil |
nil |
|
|
Target Sample Size
|
Total Sample Size="34"
Sample Size from India="34"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
15/11/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="2"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
Visuospatial Working Memory is necessary for people to live study and work effectively Its deficiency or impairment can prevent people from living a normal life and its degeneration can lead to inefficiency in learning and work Purpose To determine the effect of physical activity on visuospatial working memory among middle aged adults. Methods N n 34 middle-aged adults will be recruited according to specified inclusion and exclusion criteria, using a convenience sampling method in a single-group pre-post design. The intervention will consist of a High-Intensity Functional Training (HIFT) protocol with outcomes measured using the N-back test and Corsi block-tapping tasks. These outcomes will be assessed twice pre intervention and after completing 3-month HIFT intervention Each HIFT session will begin with a dynamic warm up followed by a structured sequence alternating 30 seconds of high-intensity anaerobic exercises like sprints and jumps with 30 seconds of bodyweight or free-weight resistance exercises ie aerobic exercises such as push ups squats and presses Another 30 seconds of anaerobic exercise is paired with an additional 30 seconds of resistance training i.e. aerobic exercises, progressing from bodyweight to free weights. After each round, participants will have 2 minutes rest repeating this cycle five times per session. Each session will end with a 5-minutes cool-down involving stretching exercises Data Analysis Data will be analyzed using the Statistical Package for the Social Sciences SPSS version 26 The Shapiro Wilk test will be used to assess normality. If the data is found to be normally distributed a paired t-test will be applied If the data is not normally distributed the Wilcoxon Signed Rank test will be used Keywords Physical activity, Working memory Middle Aged adults |