1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [mandubrunosai231065@gmail.com].
   


6. For how long will this data be available start date provided 01-08-2027 and end date provided 01-08-2032?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - nil

The aim of this study is to assess and compare the effect of one time versus two time Piezoperforation in orthodontic tooth movement during enmasse retraction in maxilla using piezotome

To assess the orthodontic tooth movement using one time piezoperforation compared to control

To assess the orthodontic tooth movement in Two time Piezoperforations compared to control.

 To compare the orthodontic tooth movement using one time versus two time piezoperforation compared to control.

Procedure

Participants of age 18-25 years with bimaxillary protrusion or Angle’s class II division 1 malocclusion  with mild crowding 1-3 mm assessed by little’s irregularity index requiring extraction of upper 1^st premolars will be selected from the outpatient department of Orthodontics. written informed consent will be taken. patients will be selected and randomly assigned into test and control sites by block randomisation . Levelling and alignment will be done. Premolars will be extracted and the trial starts after one month of extraction T0 and en-masse retraction of the anterior teeth will be initiated. The trial ends at the end of 3 months T4

Piezoperforations will be performed using piezotome , under local infiltration of 2ml Lignocaine . Three small perforations with each perforation of 1.5 mm diameter and 4 mm depth were done bilaterally in the extraction space distally to the canine.The perforations were spaced 3 mm apart vertically , which was measured using William’s periodontal probe clinically. Bleeding is controlled, and canine retraction will be started immediately on both sides using Nickel Titanium closed coil springs delivering 150 gm force. The second MOP will be performed only in the Group III experimental group  6 weeks  after the first MOP.

Group I -No intervention in the Control group

Group II-One time intervention of  Piezoperforation will be given one month after extraction of premolars

Group III-Two time interventions of piezo perforations will be given. The first intervention will be given after 1 month of extraction of premolars, and the second intervention will be given at the end of the 6^th week.

Impressions will be taken using alginate, and models will be poured. Measurements will be made using digital callipers with a sharpened fine edge of accuracy to 0.01mm.

 Each of the study subject will be provided with a specifically designed visual analogue scale VAS diary  and are requested to note the intensity of perceived pain using the terms 0 – no pain to 10- the highest pain on a 10cm visual analogue scale at various points of time such as t1-2 hrs after piezoperforation,t2-6 hrs , t3 –12 hrs, t4 -24 hrs,t5 – 2 days

 The amount of tooth retraction will be measured at the 2nd T1, 4th T2, 8th T3, and 12th T4 weeks when the patient is scheduled for routine check-up visits.

The radiographs will be taken at T0, T2, T4 to evaluate the inclination of canines and molars.