Patients diagnosed with OSMF and clinically graded as stage II and III OSMF according to Khanna and Andrade grading will be included. Demographic data with detailed history will be obtained about personal, habit and medical history followed by clinical examination and following parameters will be evaluated by mouth opening by maximal interincisal distance using vernier callipers, burning sensation will be assessed subjectively using visual analogue scale, colour of mucosa will be evaluated under natural light and this data will be numbered as  pink-1, pale pink-2, pale-3, blanched-4.The patients will be randomly allocated into the three groups. Randomization will be done according to computer generated block design. All patients will be counselled for habit cessation and will be undergoing oral prophylaxis before commencing the injection therapy. Intramucosal injections will be administered on the affected buccal mucosa and retromolar region o.2ml in each site once weekly for 6 weeks. All patients will be trained and  instructed to do mouth opening exercises using Heisters screw in every follow-up  throughout treatment period. Parameters will be evaluated every 2 weeks within the 6 weeks of injection therapy followed by 3 months