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CTRI Number  CTRI/2025/07/091759 [Registered on: 25/07/2025] Trial Registered Prospectively
Last Modified On: 25/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Single Arm Study 
Public Title of Study   Yashtimadhu moola churna for improving short term memory in children 
Scientific Title of Study   Open labelled, single arm clinical trial to evaluate the role of yashtimadhu moola churna as a medhya rasayan for improving short term memory in children of Age 12 to 16 years 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Ajay Shivajirao Thote 
Designation  PhD Scholar 
Affiliation  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli 
Address  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli Taluka Panhala District Kolhapur

Kolhapur
MAHARASHTRA
416114
India 
Phone  9960588434  
Fax    
Email  ajayiamthebest@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Vasundhara Borakhade 
Designation  Associate Professor and PhD Guide 
Affiliation  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli 
Address  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli Taluka Panhala Distric Kolhapur

Kolhapur
MAHARASHTRA
416114
India 
Phone  9822885710  
Fax    
Email  vasudhaborakhade@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Ajay Shivajirao Thote 
Designation  PhD Scholar 
Affiliation  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli 
Address  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli Taluka Panhala District Kolhapur

Kolhapur
MAHARASHTRA
416114
India 
Phone  9960588434  
Fax    
Email  ajayiamthebest@gmail.com  
 
Source of Monetary or Material Support  
Nil 
 
Primary Sponsor  
Name  Ajay Shivajirao Thote 
Address  Yashwant Ayurvedic College Post Graduate Training and Research Centre Kodoli Taluka Panhala District Kolhapur 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Ajay Shivajirao Thote  Yashwant Ayurvedic College, Post Graduate Training & Research Centre, Kodoli  OPD no. 1 - Kayachikitsa, Ground floor.
Kolhapur
MAHARASHTRA 
9960588434

ajayiamthebest@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Yeshawant Ayurved College Kodoli  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  School going children of age 12 to 16 i.e. 8th and 9th standard students 
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmDrugClassical(1) Medicine Name: Yashtimadhu, Reference: Charak Samhita Chikitsasthana, Route: Oral, Dosage Form: Churna/ Powder, Dose: 3(g), Frequency: od, Bhaishajya Kal: Abhakta, Duration: 3 Months, anupAna/sahapAna: Yes(details: Milk), Additional Information: -
 
Inclusion Criteria  
Age From  12.00 Year(s)
Age To  16.00 Year(s)
Gender  Both 
Details  Subjects of age 12 to 16 specifically school going children of standard 8th and 9th will be selected.
IQ score as per Malin’s Intelligence Scale for Indian Children (MISIC) in between 70 to 109.
200 participants from Marathi medium school and 200 participants from English medium school will be selected.
Subjects will be selected irrespective of gender, religion, and socio-economical condition.
Parent of the subject who give informed written consent will be included. 
 
ExclusionCriteria 
Details  Subjects of age below 12 and above 16 specifically school going children of standard below 8th and above 9th will be excluded.
IQ score as per Malin’s Intelligence Scale for Indian Children (MISIC) below 70 and above 109.
Subjects who are taking any authenticate memory enhancer drug or formulations will be excluded.
Subjects who are taking any treatment from psychiatrist for any mental problem will be excluded.
Subjects who stopped psychiatric treatment in last 3 months will be excluded.
Female participants having irregular menses, PCOS will be excluded. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
Short Term Memory
a. Auditory-verbal Short term memory test
b. Visual-verbal Short term visual memory test for Numbers
c. Visual-verbal Short term visual memory test for Words 
90 Days 
 
Secondary Outcome  
Outcome  TimePoints 
1. Bala
2. Agni
3. Varna
4. Swara
5. Aamay nashan
6. IQ Score as per Malin’s Intelligence Scale for Indian Children (MISIC)
7. Weight
8. BMI 
90 Days 
 
Target Sample Size   Total Sample Size="400"
Sample Size from India="400" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 3 
Date of First Enrollment (India)   05/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="2"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Ayurveda has duly recognized the individuality of Mana and Sharira and their inseparable and interdependent relation in living body. ManaAtma and Sharira together leads to the Ayu of an individual. One who has balanced Dosha, balanced Agni, and properly formed Dhatus; proper elimination of Malas, well-functioning bodily processes, and whose mind, soul and senses are full of bliss is called a healthy person. Difference in the human and other living species on the planet earth is the human brain. The human brain is also responsible for the development of human in all aspect and for this memory plays an important role. All living species learn everything by remembering previous experience but humans are more developed than other because of the intellect. Memory and Intelligence of human makes them superior in all aspect, which changes the standard of living of humans from time to time.

Ayurveda coined the term Medha which means Dharana Shakti i.e. Intellectual and / or retention and Rasayan means therapeutic procedure or preparations that on regular practice which boost nourishment, health, memory, intellect, immunity and hence longevity.

The Ayurvedic texts describes a set of rejuvenate to impact biological sustenance to the bodily tissues. These remedies are called Rasayan which are claimed to act as micronutrients. Some of these Rasayanas are organ and tissue specific. Those specific to brain tissue are called Medhya Rasayan. Medhya Rasayan is a group of four medicinal plants that can be used singly or in combinations explained by Acharya Charak in first adhyaya of Charaka Samhita Chikitsasthana i.e. Rasayan Adhyay. In school life, children are more focused on the study to have the bright future in life. Students may mugging up the definitions, formulae or try to remember it by writing it on a paper so many times to get good grades or marks in the examination. Students will not get good marks by reading a book one day before exam, they need to study for a long period of time with consistency before any examination, and like this long term practice of Medhya Rasayan is required to enhance the memory.

Four medhya rasayan are explained by Acharya Charaka. Yashtimadhu is to taken in the form of churna and aupana is dugdha i.e. cow milk, which is considered to be palatable among all four medhya rasayanSwaras of Mandukparni and Guduchikalka of Shankhapushpi is too explained as a medhya rasayan but swarasa and kalka are not as palatable as churna in children.

Yashtimadhu is commonly known as Kanthya and kanda i.e. bark is used for it in day today practice. So I have choose Yashtimadhu moola churna as a medhya rasayan for research study as the medhya karma of Yashtimadhu is neglected though it is explained in Charaka samhita.

DheeDhruti and Smruti definitions given by Chakrapanidatta in Ayurvedadipika, Arunadatta in Sarvangasundara and Hemadri in Ayurvedarasayan, the word Smruti is relate with the word memory among DheeDhruti and Smruti. Exam pattern in our education system is completely based on memory i.e. smaranshakti. So Yashtimadhu churna is selected for this research study out of four medhya rasayan dravyas because churna is palatable and anupana for it is milk thus it will be easy for the children to take the medicine on daily basis for 3 months of time period.
 
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