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CTRI Number  CTRI/2025/08/093062 [Registered on: 14/08/2025] Trial Registered Prospectively
Last Modified On: 19/10/2025
Post Graduate Thesis  Yes 
Type of Trial  Observational 
Type of Study   Follow Up Study 
Study Design  Other 
Public Title of Study   Comparing Two Scoring Methods to Diagnose Appendicitis in Adults 
Scientific Title of Study   A prospective observational comparative study between Adult Appendicitis Score and Modified Alvarado Score in the diagnosis of Acute Appendicitis 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Devansh Bhambri 
Designation  Junior Resident 
Affiliation  Kasturba Medical College, Manipal 
Address  Department of General Surgery, 3rd floor, Smt. Sharada Madhav Pai OPD, Kasturba Hospital, Manipal

Udupi
KARNATAKA
576104
India 
Phone  7837473068  
Fax    
Email  devansh.kmcmpl2024@learner.manipal.edu  
 
Details of Contact Person
Scientific Query  
Name  Dr K Rajgopal Shenoy 
Designation  Professor and Head of Unit 
Affiliation  Kasturba Medical College, Manipal 
Address  Department of General Surgery, 3rd floor, Smt. Sharada Madhav Pai OPD, Kasturba Hospital, Manipal

Udupi
KARNATAKA
576104
India 
Phone  9845243460  
Fax    
Email  rajgopal.shenoy@manipal.edu  
 
Details of Contact Person
Public Query  
Name  Dr Pavan M Bhat 
Designation  Assistant Professor 
Affiliation  Kasturba Medical College, Manipal 
Address  Department of General Surgery, 3rd floor, Smt. Sharada Madhav Pai OPD, Kasturba Hospital, Manipal

Udupi
KARNATAKA
576104
India 
Phone  9731243720  
Fax    
Email  pavan.bhat@manipal.edu  
 
Source of Monetary or Material Support  
Kasturba Medical College and Hospital, Manipal, Udupi, Karnataka, India 576104 
 
Primary Sponsor  
Name  Dr Devansh Bhambri 
Address  Department of General Surgery, 3rd Floor, Smt. Sharada Madhav Pai OPD, Kasturba Hospital, Manipal, Udupi, Karnataka, India 576104 
Type of Sponsor  Other [(Self)] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Devansh Bhambri  Kasturba Medical College and Hospital  Room no 8, Department of General Surgery, 3rd floor, Smt. Sharada Madhav Pai OPD, Kasturba Hospital, Manipal
Udupi
KARNATAKA 		 7837473068

devansh.kmcmpl2024@learner.manipal.edu 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Kasturba Medical College and Kasturba Hospital Institutional Ethics Committee - 2   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K35-K38||Diseases of appendix,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  All patients clinically diagnosed with acute appendicitis undergoing open or laparoscopic appendectomy with histopathological confirmation of diagnosis in the same admission 
 
ExclusionCriteria 
Details  Patients less than 18 years of age
Patients with appendicular mass formation
Patients for whom C-reactive protein(CRP) is not sent as a consultant specific protocol 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To assess the sensitivity and specificity of both scores in diagnosing Acute Appendicitis  At baseline 
 
Secondary Outcome  
Outcome  TimePoints 
To assess & compare the positive predictive value & negative predictive value of both scores  At baseline 
 
Target Sample Size   Total Sample Size="53"
Sample Size from India="53" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   25/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="10"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  		 Not Applicable 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

The study is a prospective observational study that will be conducted in the General Surgery Department of Kasturba Hospital, Manipal. The study needs to be approved by the Institutional Ethics Committee. Informed consent will be taken from the participants at the time of enrolment on IP basis in the ward/triage. Study population will include patients clinically diagnosed with acute appendicitis, undergoing laparoscopic or open appendicectomy with histopathological confirmation of diagnosis. The patient will be evaluated with history and clinical examination. The routine blood investigations that will be sent before surgery will be analyzed. Thereafter, both Modified Alvarado Score and Adult Appendicitis Score will be applied on these findings and probability of having acute appendicitis will be calculated. Post operatively, the specimen will be sent for histopathological examination. Final diagnosis will be based on histopathology report. The sensitivity, specificity, PPV and NPV of both the scoring systems will be calculated and compared.

 
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