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CTRI Number  CTRI/2025/08/092944 [Registered on: 12/08/2025] Trial Registered Prospectively
Last Modified On: 12/08/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   To study effect of Dhatri Pindi on Pittaj Abhishynada 
Scientific Title of Study   Assessment of efficacy of Dhatri Pindi in Pittaj Abhishyanda:Randomised Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nikita Milind Rohokale  
Designation  PG Scholar  
Affiliation  PMTs Ayurveda College,Shevgaon 
Address  OPD NO 102 SHALAKYATANTRA DEPARTMENT,SHRI EKNATH AYURVED RUGNALAYA,PMTs Ayurveda College,Shevgaon Akhegaon road ,Tal.Shevgaon
House no 21 Rohokale Lane ,Nalegaon,Ahmednagar
Ahmadnagar
MAHARASHTRA
414502
India 
Phone  8275446766  
Fax    
Email  rohokalenikita@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Swati Vishnu Sarwade 
Designation  Professor and HOD 
Affiliation  PMTs Ayurveda College,Shevgaon 
Address  OPD NO 102 SHALAKYATANTRA DEPARTMENT,SHRI EKNATH AYURVED RUGNALAYA,PMTs Ayurveda College,Shevgaon Akhegaon road ,Tal.Shevgaon

Ahmadnagar
MAHARASHTRA
414502
India 
Phone  9422935125  
Fax    
Email  drsarwadeswativ@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Swati Vishnu Sarwade 
Designation  Professor and HOD 
Affiliation  PMTs Ayurveda College,Shevgaon 
Address  OPD NO 102 SHALAKYATANTRA DEPARTMENT,SHRI EKNATH AYURVED RUGNALAYA,PMTs Ayurveda College,Shevgaon Akhegaon road ,Tal.Shevgaon
PMTs Staff Quarters,Ahekhgaon road Shevgaon
Ahmadnagar
MAHARASHTRA
414502
India 
Phone  9422935125  
Fax    
Email  drsarwadeswativ@gmail.com  
 
Source of Monetary or Material Support  
OPD NO 102 SHALAKYATANTRA DEPARTMENT,SHRI EKNATH AYURVED RUGNALAYA,PMTs Ayurveda College,Shevgaon Akhegaon road ,Tal.Shevgaon,Dit.Ahmednagar-414502 India 
 
Primary Sponsor  
Name  PMTs Ayurveda College 
Address  Shevgaon Akhegaon road,Tal.Shevgaon,Dist.Ahmednagar,Maharashtra 414502 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nikita Milind Rohokale   PMTs Ayurveda College, Shevgaon   SHALAKYATANTRA DEPARTMENT, OPD NO. 102 SHRI EKNATH AYURVED RUGNALAYA, PMTs Ayurveda College, Shevgaon Akhegaon road, Tal. Shevgaon, Dist. Ahmednagar, Maharashtra
Ahmadnagar
MAHARASHTRA 
8275446766

rohokalenikita@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
PMT/ACS/IEC- 12/SHLK Institutional Ethics Committee   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:H100||Mucopurulent conjunctivitis. Ayurveda Condition: PITTABISHYANDAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  The patients presenting with signs and symptoms of Pittaj Abhishyanda (Netra
lalima, Kleda, Daah etc.).
Patients willing to give informed & written consent.
Irrespective of sex and Socioeconomics status.
 
 
ExclusionCriteria 
Details  1. Patients suffering from trachoma, dacrocystitis etc.
2. Patients with known case of HIV/Hbsag
3. Patients not willing for trial. 
 
Method of Generating Random Sequence   Permuted block randomization, fixed 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To evaluate efficacy of Dhatri Pindi Kalpna in Pittaj Abhishyanda.  7 day treatment with 4 follo up 0,3,5 and 7th day 
 
Secondary Outcome  
Outcome  TimePoints 
To review data related to Pittaj Abhishyanda and Pindi Kalpna in Ayurvedic texts.
To review data related to Bacterial Conjunctivitis in Modern texts.
To evaluate efficacy of Moxifloxacin eye drop in Pittaj Abhishyanda.
To compare efficacy between Dhatri Pindi Kalpna and Moxifloxacin in Pittaj
Abhishyanda.
To observe any Adverse Drug Reaction. 
7 day treatment with 4 follo up 0,3,5 and 7th day 
 
Target Sample Size   Total Sample Size="72"
Sample Size from India="72" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   29/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Abhishyanda is considered as Sarvagata Netraroga which is a dreadful disease and possess symptoms of conjunctivitis as per the modern science. The inflammation of conjunctiva mainly occurs in Abhishyanda which can spread through Rakta. Abhishyanda if not cured then it can causes Adhimanth associated with acute pain. The other complication may include, Sandhigat roga shuklagat roga, Krishnagat roga and Vartmagat roga, etc. Abhishyanda is put as disease amongst the seventeen Sarvagat rogas. Ayurveda classics mentioned various types of Abhishyanda including Vataja Abhishyanda, Pittaja Abhishyanda, Kaphaja Abhishyanda and Raktaja Abhishyanda. The disease involves Kledana in Doshas and Dhatu due to which profuse discharge comes out from the eye. Therefore excessive discharge from eye is the major feature of Abhishyanda. Ayurveda described different approaches such as Anjana, Pariseka, Pralepa, Aschyotana, Tarpana, Sweda ,Pindi ,Bidalak , and Putpaka for the management of various Netraroga. Some ayurveda formulations and herbs also offers relieves in the symptoms of Abhishyanda,In view of the magnitude of the problem, the discomfort it causes to the patients and the cost of the treatment, there is need to develop a therapy which is free from side effects, cheaper, and has a significant effect in alleviating the symptoms of the patients. As above mentioned kalpanas the Pindi Kalpna is the topic which remained untouched.there is no significant work done on Pindi Kalpna in today’s era hence ,This study is an attempt in this direction to evaluate the effects of Dhatri Pindi on mucopurulent conjunctivitis. However amongest the topical remedies the most simple,practical yet effective procedures giving better results in local inflammations and painful condition of the eye thereby giving an instant and immediate effect is Pindi kalpna,For Dhatri Phalam- The literary study of fruit Amalaki from Ayurvedic texts and modern researches concludes that fruit that is Embelica officinalis has following properties according to Ayurveda, Rasayana, Vrushya, Chakshushya, Panduhar, Krimihar, Udarhar, Vaysthapana, Pramehhar, Kamalahar, and according to modern Antioxidant, Anti-inflammatory,Antimicrobial,Analgesic, Anticancer, Hepatoprotective, Gastroprotective, Anticarcinogenic.

 
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