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CTRI Number  CTRI/2025/08/093157 [Registered on: 18/08/2025] Trial Registered Prospectively
Last Modified On: 14/08/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Single Arm Study 
Public Title of Study   Jeevanthyadi Ghritapan in Timir with special reference to Myopia in school going children. 
Scientific Title of Study   Single Arm Clinical Study To Evaluate the efficiency of Jeevanthyadi Ghrutpan in Timir with special reference to Myopia in school going children. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Ojas Ajay Dhobe 
Designation  MD Scholar Shalakyatantra (Ayurveda) 
Affiliation  LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center 
Address  Department of Shalakyatantra OPD No 11, Unit 1 LRP Ayurvedic Medical College and Hospital Post Graduate Institute and Research Center, Uran Islampur Tal Walawa,Sangli Maharashtra

Sangli
MAHARASHTRA
415409
India 
Phone  7020958205  
Fax    
Email  princydhobe99@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Neeta Ramesh Patil 
Designation  Assistant Professor  
Affiliation  LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center 
Address  Department of Shalakyatantra OPD No 11,Unit 1 LRP Ayurvedic Medical College and Hospital Post Graduate Institute and Research Center,Uran Islampur Tal Walawa,Sangli Maharashtra

Sangli
MAHARASHTRA
415409
India 
Phone  9975335457  
Fax    
Email  drneetapatil@rediffmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Neeta Ramesh Patil 
Designation  Assistant Professor  
Affiliation  LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center 
Address  Department of Shalakyatantra OPD No 11, Unit 1 LRP Ayurvedic Medical College and Hospital Post Graduate Institute and Research Center,Uran Islampur Tal Walawa,Sangli Maharashtra

Sangli
MAHARASHTRA
415409
India 
Phone  9975335457  
Fax    
Email  drneetapatil@rediffmail.com  
 
Source of Monetary or Material Support  
LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center,Uran Islampur,Tal Walawa,Sangli- 415409, Maharashtra,India 
 
Primary Sponsor  
Name  Dr Ojas Ajay Dhobe  
Address  LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center,Uran Islampur,Tal Walawa,Sangli- 415409, Maharashtra,India 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Ojas Ajay Dhobe  LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center  Department of Shalakyatantra,OPD No 11,Unit 1,LRP Ayurvedic Medical College And Hospital Post Graduate Institute And Research Center, Uran Islampur,Tal Walawa,Sangli- 415409, Maharashtra,India
Sangli
MAHARASHTRA 
7020958205

princydhobe99@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
LRP Ayurvedic Medical College Institutional Ethical Committee   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:H521||Myopia. Ayurveda Condition: TIMIRAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Comparator ArmDrugClassical(1) Medicine Name: Jeevantyadi Ghrut, Reference: Ashtanga Hrudayam Uttarasthana Adhyay 13/2-3, Route: Oral, Dosage Form: Ghrita, Dose: 3(g), Frequency: od, Bhaishajya Kal: Abhakta, Duration: 30 Days, anupAna/sahapAna: Yes(details: Koshna jal), Additional Information: -
Intervention  Nil  Nil 
 
Inclusion Criteria  
Age From  5.00 Year(s)
Age To  17.00 Year(s)
Gender  Both 
Details  1. Patients willing for trial.

2. Patient having simple Myopia with low error less or equal minus 3D with normal ophthalmoscopic findings. (Optic Disc - margins sharp, yellowish orange to pink colour, shape round or oval, Vessels - No arterial light reflex, No exudates or haemorrhages, Macula-Macula is located 2.5 disc diameter temporal to optic disc.)

3. Patient of Age group between 5-17 years with sign and symptoms of simple myopia as per Ayurveda and Modern aspect. (Avyaktani Rupani Sarvaneva Prapashyati i. e. Blurred vision, Asthenopia) 
 
ExclusionCriteria 
Details  A. Patients of Moderate Myopia (when the error is between -3D to -6D)

B. Patients of High Myopia (when the error is more or equal to -6 D)

C. Patients having any other known ocular pathology involving Chalazion, Stye, Glaucoma, Cataract, Retinopathy, Corneal ulcer, Conjunctivitis, Uveitis. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To evaluate the efficacy of Jeevantyadi ghritapan in timir with special reference to Myopia in school going children   30 days 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="40"
Sample Size from India="40" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   11/09/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="2" 
Recruitment Status of Trial (Global)   Not Yet Recruiting 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary   Shalakya Tantra addresses illnesses that arise above the clavicle.
Timir can be found in our ancient books that states eyeball has six patals or layers, of which two are ’Bahya’ and are referred to as Bahya vartmagat patalas, while the remaining four cover the eyeball. These four netra patals are afflicted, which causes Timira to appear. Doshas that become asharya in the Pratham patal result in "aspashta roopa darshan," which is the pradurbhava of "Timira." When Timira is connected to "Roga," it is referred to as "Kacha".

Sushruta states that Timir is caused by a variety of factors that,when it enters the internal orbital organs through Sira and resides in First Patala, cause pathology in that area. This Timirarambhak dosha produces a slight veiling of the eyes.
Vaghbhat claims that clear objects might also appear blurry for no apparent reason.
Sushruta states that when this Timirarambhak dosha reaches
Diwityapatala, vision continues to deteriorate. Flies, mosquitoes, hair,cobwebs, ornaments (Mandala, Pataka), oasis (Mrugjala), earrings(Kundala), star movement, or frog hopping (Pariplava) are examples of hallucination-like items.thread cannot flow through a needle; somebody with defective perception (Index Hypermetropia or Myopia) perceives far-off objects as if they are closer and nearer.

Vagbhat states that when dosha enters Diwityapatala, Bhuta, orexisting close items, are seen easily, whereas Abhuta, or nonexistentfigures like flies, mosquitoes, hair, etc., are not visible.

Clinical picture of Timir can nearly stimulates with Myopia.
Study goal is to indentify treatment for Timir that is Myopia in children .As Condition becoming widespread in the child group.

Jeevanthyadi ghrit described in Ashtang hridayam uttarstan adhyay 13 shlok 2-3 ,noted for its Rasayana(rejuvenating) and Chakshushya (eye-beneficial) qualities.

This is accurate given that the number of people who need to wear glasses is rising daily.
According to data the prevalence of Myopia is estimated to be 2–10% of school going children in India so it has became crucial to investigate alternative treatment strategy for management of myopia due to lack of management and only modern alternative available is spectacles.
 
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