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CTRI Number  CTRI/2025/07/091793 [Registered on: 27/07/2025] Trial Registered Prospectively
Last Modified On: 25/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Evaluating The Role Of Boericke Repertory in Homeopathic Treatment Of Migraine 
Scientific Title of Study   Clinical Utility Of Boericke Repertory In Cases Of Migraine  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Gargav Arunbhai Jani 
Designation  M.D. Part 2 SCHOLAR  
Affiliation  C.D. Pachchigar College Of Homeopathic Medicine And Hospital 
Address  C.D. Pachchigar College Of Homeopathic Medicine And Hospital Department Of Case Taking And Repertory Post Graduation Division 2nd Floor Near Navjivan Circle Udhana Magdalla Road Surat 395001

Surat
GUJARAT
395001
India 
Phone  9586057911  
Fax    
Email  gargavjani1412@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Shrirang N Vyas 
Designation  Professor Of Case Taking And Repertory  
Affiliation  C.D. Pachchigar College Of Homeopathic Medicine And Hospital 
Address  C.D. Pachchigar College Of Homeopathic Medicine And Hospital Department Of Case Taking And Repertory Post Graduation Division 2nd Floor Near Navjivan Circle Udhana Magdalla Road Surat 395001

Surat
GUJARAT
395001
India 
Phone  9426185880  
Fax    
Email  drsnvyas@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Shrirang N Vyas 
Designation  Professor Of Case Taking And Repertory  
Affiliation  C.D. Pachchigar College Of Homeopathic Medicine And Hospital 
Address  C.D. Pachchigar College Of Homeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat Gujarat India 395001

Surat
GUJARAT
395001
India 
Phone  9426185880  
Fax    
Email  drsnvyas@gmail.com  
 
Source of Monetary or Material Support  
C.D. Pachchigar College Of Homoeopathic Medicine And Hospital 
 
Primary Sponsor  
Name  C D Pachchigar College Of Homeopathic Medicine And Hospital  
Address  C.D. Pachchigar College Of Homeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat Gujarat India 395001 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Gargav Arunbhai Jani  C.D. Pachchigar College Of Homeopathic Medicine And Hospital  Department Of Case Taking And Repertory Post Graduation Division 2nd Floor Surat Gujarat
Surat
GUJARAT 
9586057911

gargavjani1412@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee Of C.D.Pachchigar College Of Homoeopathic Medicine And Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G43||Migraine,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Individualized Homoeopathic medicine   Individualized Homoeopathic medicine Will Be Prescribed On The Basis Of Totality Of Symptoms And Individual Susceptibility The Medicine Will Be Administered Orally In The Form Of Medicated Globules 4 to 6 Globules Per Dose The Intervention Will Be 15 to 30 Days  
Comparator Agent  Nil  Nil 
 
Inclusion Criteria  
Age From  15.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  Patients Of Both Sex And From 15 years To 50 Years Of Age Are Selected. 
 
ExclusionCriteria 
Details  Emergency cases. (e.g., like – cerebral vascular stroke, Hypertensive headache, head injury etc).
Subjects with active treatment for any other chronic disease.
Cases with advanced pathological condition. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To understand the utility of boericke repertory in prescription of migraine cases.  9 months 
 
Secondary Outcome  
Outcome  TimePoints 
To Relief The Patient From Migraine Triggering Factor And Also Relieving From Recurrent Episode Of Migraine With Healthy Life Style.  9 Months 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   07/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

 

6.

BRIEF RESUME OF INTENDED WORK

6.1

 

NEED FOR THE STUDY

 

Globally, headache disorders affect approximately 40% of the population, or 3.1 billion people in 2021, and are more common in females compared to males. They are among the top three most common neurological conditions for most age groups, starting with age 5 and remaining in the top three until the age of 80. Despite some regional variations, headache disorders are a worldwide problem, affecting people of all races, income levels and geographical areas.

 

Not only is a headache painful, but it is also disabling. According to Global Health Estimates 2019, headache disorders were found to be third highest cause of disability-adjusted life years (DALYs) worldwide, after stroke and dementia.

 

Headache disorders impose a burden on individuals that can include substantial personal suffering, impaired quality of life and financial cost. Repeated headache attacks, and often the constant fear of the next one, damage family life, social life, and employment. The long-term effort of coping with a chronic headache disorder may also predispose the individual to other illnesses. 

 

REPERTORY is a systematically and logically arranged index of homoeopathic materia medica , which is full of information collected from toxicology , drug proving and clinical experience. The repertory helps to find out the required symptom together with medicine or group of medicines having different grades.

It is a connecting link between the materia medica and disease.

 

For treatment of headache and improving the quality of life of patient HOMOEOPATHY is a harmless and most appropriate way. In the homoeopathic way of treatment as per instruction given by master Sammual Hahnamann in organon of medicine. after case taking, in search of similimum remedy REPERTORY play important role in selection of similimum medicine.

 

As no one person can carry all the symptom of all the remedies in the mind, a concordance of index is needed. we term a symptom index a REPERTORY.

- Dr. Elizabeth Wright 

It is impossible to practice homoeopathy without the aid of repertories and the best repertory is fullest. - Dr. J. H. Clarke

 

The use of repertory in homoeopathy practice is a necessity if one is to do careful work. Our materia medica is so cumbersome without the repertory that the best prescriber must meet with only indifferent results. -Dr. Kent

 

So to find similimum medicine in individual case of disease, the approach is the most important to choose repertory. On bases of the plan, construction and philosophical background of repertory and demand of particular approach to workout in any case of disease we select Repertory.

 

After taking case as per guided by Dr. Hahnemann in Aphorism- 83 to 104 in organon of medicine, when case is lacking in mental generals and physical general but rich in common symptoms. Or in case with clinical diagnosis Or short case with a few symptoms the Clinical repertory play essential part to find similimum remedy.

 

In clinical repertories the BOERICKE REPERTORY is most widely used among all the repertories.

 

In the cases of Migraine headache the boericke repertory is very useful.

 

Boericke has mentioned all the symptoms in proper location, sensation, modalities and concomitant. Along with it ailments are given in boericke repertory.

 

All the remedies in rubrics are clinically verified as well as well proven, so authenticity in cases of headache is more reliable. 

 

we can give a better life to the patient and restore back patient to healthy state as Dr.Hahnemann sir has mention in Aphorism-1 in Organon of medicine. By using proper repertory, efficiency of results can be improved in cases of headache & we can reduce disability adjust life year in patient.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


 

 

 

6.2

REVIEW OF LITERATURE:

 

POCKET MANUAL OF HOMOEOPATHIC MATERIA MEDICA WITH REPERTORY.

-Dr. William / Oscar E. Boericke

1) INTRODUCTION

2) PREFATORY NOTES

3) CONSTRUCTION

Introduction

A repertory appended to Pocket Manual of Homoeopathic Materia Medica by Oscar E. Boericke is classed under the group of General Clinical Repertory covering whole symptomatology. This repertory is based on clinical finding & clinical verifications, and major source of which is William Boericke’s Materia Medica. Boericke & Runyon, 1049 pages, published this repertory. The Materia Medica by William E. Boericke was issued in 1901. The repertory was added to the 3 rd edition in 1906. The repertory is constructed differently than that of either Kent or Boenninghausen, and takes a bit of work to become familiar with. Current is the ninth edition of this repertory that was published in June 1927. This repertory is very popularly used in acute as well as in chronic cases.

 

Prefatory Notes

 

In the preface to the repertory Dr. Oscar E. Boericke writes that: -

In conformity, which established repertorial methods, the division of sections is somewhat the old Hahnemanian method.

Headings and sub-headings or the specific conditions or symptoms comprise under the later are arranged in alphabetical order and this is more or less adhered through out the entire work.

 

All the headings when extensive in scope are presented under : -

Cause

Type

Location

Character of pain

Concomitants

Modalities

 

Technical names of the diseases are bracketed for which is in strict accord with Homoeopathic requirements, to prescribe for the symptoms of each Specific case, and not for mere the name of the disease.

·       Almost 1409 Remedies are considered while constructing this repertory and they are arranged in alphabetical order.

 

 

 Italics - indicates the more frequently Verified clinical remedy - 2 marks.

 Roman - Remedies printed in Roman - 1marks Lastly he adds,

it is only by persistent study of one repertory, its peculiar and intricate arrangements gradually crystallize themselves in definite outline in the mind.

 

Construction of book

The first part of the book is Materia Medica and the second part is repertory – followed by an: -

a) Index to the Repertory

b) Therapeutic index

c) List of remedies with common and Latin names

 

Sections of Boerickes Repertory 

 

§  The repertory has 25 chapters:

 

FROM  -REPERIRE  BY PROF.DR.VIDYADHAR R.KHANAJ.

 

 

 

 

HEADACHE

 

Primary headache syndromes

 

 

Primary headache syndrome

·       Migraine (with or without aura)

·       Tension – type headache

·       Trigeminal autonomic cephalalgia(including cluster headache)

·       Primary stabbing/coughing/exertional/sex related headache

·       Thunderclap headache

·       New daily persistent headache

Secondary causes of headache

·       Medication overuse headache (chronic daily headache)

·       Intracranial bleeding (subdural heamatoma , subarachnoid or intracerebral heamorrhage)

·       Raised intracranial pressure (brain tumour, idiopathic intracranial hypertension )

·       Inflammatory disease (temporal arteritis , other vasculitis, arthritis)

·       Referred pain from other structure (orbit , temporomandibular joint , neck)

 

 

 

·       Migraine :

 

Migraine usually appears before middle age, or occasionally in later life; it affects about 20% of females and 6% of males at some point in life. Migraine is usually readily identifiable from the history, although unusual variants can cause uncertainty.

 

The 80% of patients with characteristic headache but no ‘aura’ are said to have migraine without aura (previously called ‘common’ migraine). Migraine headache is usually severe and throbbing, with photophobia, phonophobia and vomiting lasting from 4 to 72 hours. Movement makes the pain worse and patients prefer to lie in a quiet, dark room. In a small number of patients, the aura may persist, leaving more permanent neurological disturbance. This persistent migrainous aura may occur with or without evidence of brain infarction.

 

 

  • Tension-type headache :-

 

This is the most common type of headache and is experienced to some degree by the majority of the population.

  • The pain of tension headache is characterised as ‘dull’, ‘tight’ or like a ‘pressure’, and there may be a sensation of a band round the head or pressure at the vertex. It is of constant character and generalised, but often radiates forwards from the occipital region.
  • It may be episodic or persistent, although the severity may vary, and there is NO associated vomiting or photophobia.

Tension-type headache is rarely disabling and patients appear well. The pain often progresses throughout the day. Tenderness may be present over the skull vault or in the occiput but is easily distinguished from the triggered pains of trigeminal neuralgia and the exquisite tenderness of temporal arteritis.

 

  • Cluster headache :-

 

Cluster headaches (also known as migrainous neuralgia) are much less common than migraine. Unusually for headache syndromes, there is a significant male predominance and onset is usually in the third decade.

Cluster headache is strikingly periodic, featuring runs of identical headaches beginning at the same time for weeks at a stretch (the ‘cluster’). Patients may experience either one or several attacks within a 24-hour period, and typically are awoken from sleep by symptoms (‘alarm clock headache’).

Cluster headache causes severe, unilateral periorbital pain with autonomic features, such as ipsilateral tearing, nasal congestion and conjunctival injection. The pain, though severe, is characteristically brief (30–90 minutes).

 

 

In contrast to the behaviour of those with migraine, patients are highly agitated during the headache phase. The cluster period is typically a few weeks, followed by remission for months to years, but a small proportion do not experience remission.

 

  • Trigeminal neuralgia :-

 

This is characterised by unilateral lancinating facial pain, most commonly involving the second and/or third divisions of the trigeminal nerve territory, usually in patients over the age of 50 years.

 

The pain is repetitive, severe and very brief (seconds or less). It may be triggered by touch, a cold wind or eating. Physical signs are usually absent, although the spasms may make the patient wince and sit silently (tic douloureux). There is a tendency for the condition to remitand relapse over many years. Rarely, there may be combined features of trigeminal neuralgia and cluster headache (‘cluster–tic’).

 

  • Medication overuse headache :- 

 

With increasing availability of over-the-counter medication, headache syndromes perpetuated by analgesia intake are becoming much more common. Medication overuse headache (MOH) can complicate any headache syndrome but is especially common with migraine and chronic tension-type headache.

 

The most frequent culprits are compound analgesics (particularly codeine and other opiate-containing preparations) and triptans, and MOH is usually associated with use on more than 10–15 days per month.

 

Management is by withdrawal of the responsible analgesics. Patients should be warned that the initial effect will be to exacerbate the headache, and migraine prophylactics may be helpful in reducing the rebound headaches. Relapse rates are high, and patients often need help and support in withdrawing from analgesia; a careful explanation of this paradoxical concept is vital.

 

  • Headaches associated with specific activities

 

These usually affect men in their thirties and forties. Patients develop a sudden, severe headache with exertion, including sexual activity.

There is usually no vomiting or neck stiffness, and the headache lasts less than 10–15 minutes, though a less severe dullness may persist for some hours.

 

 

6.3

 

 

OBJECTIVE OF STUDY:

 

  AIM:-

 

1.     To study utility of boericke repertory in cases of Migraine.

 

 

OBJECTIVE:-

 

1.     To study efficacy of homoeopathy medicines using boericke repertory in  Migraine.

2.     To know role of homoeopathy in Migraine headache cases.

 

 

 
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