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CTRI Number  CTRI/2025/07/091878 [Registered on: 28/07/2025] Trial Registered Prospectively
Last Modified On: 24/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   A Study on the Effects of Homoeopathic Treatment for Epilepsy Using the Miasmatic Approach. 
Scientific Title of Study   Study of Epilepsy through Miasmatic Approach and Its Homoeopathic Management. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Mayurkumar Mukeshbhai Rathod 
Designation  MD Scholar Part-2 
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital  
Address  2nd Floor Organon of Medicine and Homoeopathic Philosophy Department PG Division C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9328549990  
Fax    
Email  rathodmayu2@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Snehaben Ajitkumar Patel 
Designation  Associate Professor Organon Of Medicine And Homoeopathic Philosophy Department  
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  2nd Floor Organon of Medicine and Homoeopathic Philosophy Department PG Division C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9428392287  
Fax    
Email  snehugopi@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Snehaben Ajitkumar Patel 
Designation  Associate Professor Organon Of Medicine And Homoeopathic Philosophy Department  
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  2nd Floor Organon of Medicine and Homoeopathic Philosophy Department PG Division C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9428392287  
Fax    
Email  snehugopi@gmail.com  
 
Source of Monetary or Material Support  
C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat 
 
Primary Sponsor  
Name  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Mayurkumar Mukeshbhai Rathod  C D Pachchigar College of Homoeopathic Medicine and Hospital   2nd Floor Department of Organon and Homoeopathic Philosophy PG Division C D Pachchigar College of Homoeopathic Medicine and Hospital Near Navjivan Circle Udhna Magdalla Road Surat 395001
Surat
GUJARAT 
9328549990

rathodmayu2@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee Of C. D. Pachchigar College Of Homoeopathic Medicine and Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: G40||Epilepsy and recurrent seizures,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Homoeopathic Medicine   Homoeopathic Medicine Dose As Per Requirement Of Case Through Oral Mode Of Administration Within Time Duration Of 9 Months  
Comparator Agent  Not Applicable  Not Applicable 
 
Inclusion Criteria  
Age From  2.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  1 Already diagnosed cases of Epilepsy.
2 Patients of all the socio-economical status will be included.
 
 
ExclusionCriteria 
Details  1 Non-Compliant or Unreliable patients.
2 Pregnant or Lactating women.
3 Patient undergoing recent or planned surgical interventions for
Epilepsy.
4 Patients with severe Psychiatric Co-morbid conditions, Structural or Progressive Neurological disorders and Acute Symptomatic Epilepsy will be excluded. 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To assess the role of Homoeopathic Medicines selected through
Miasmatic approach in Epilepsy. 
6 months 
 
Secondary Outcome  
Outcome  TimePoints 
To identify predominant Miasm associated with Epilepsy.  6 months 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   05/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

6 BRIEF RESUME OF INTENDED WORK

6.1 NEED FOR STUDY

A healthy human being is a balanced entity where physical, mental, and emotional well-being coexist in harmony. The brain as the control center of the body plays a crucial role in maintaining homeostasis by regulating voluntary and involuntary functions, emotions, cognition, and consciousness. A well-functioning brain ensures proper coordination between the nervous system and other organ systems allowing an individual to lead a productive life.

The brain is made up of billions of nerve cells or neurons that communicate with each other through synapses. The brain is part of the central nervous system CNS along with the spinal cord. The brain is responsible for many functions including controlling heart rate mood and body temperature. The brain is divided into left and right hemispheres and each hemisphere has four lobes. Due to some reasons when healthy normal brain experiences hyper electrical activity a typical clinical picture is produced which is called epilepsy.

Epilepsy is a neurological disorder characterized by recurrent seizures. These seizures can vary widely in their presentation and severity ranging from brief lapses of attention to full body convulsions. Understanding the underlying causes of epilepsy such as genetic factors brain injury or structural abnormalities is essential for effective management.

The miasmatic approach to disease rooted in homeopathy considers chronic diseases as arising from underlying constitutional weaknesses or inherited predispositions. Epilepsy a neurological disorder characterized by recurrent seizures is often studied through conventional medical lenses focusing on genetic metabolic or structural causes. However from a homeopathic perspective understanding epilepsy through miasmatic theory can offer deeper insights into its chronic nature underlying predispositions and individualized treatment strategies.

Reasons to Study Epilepsy Miasmatically

1 Identifying constitutional predisposition
2 Holistic individualized treatment
3 Understanding suppression and disease progression
4 Complementary insights for chronic cases

There have been studies and case reports in homeopathic literature that explore epilepsy within the therapeutic framework. However no research has been done correlating epilepsy with miasmatic consideration.

6.2 REVIEW OF LITERATURE

Earlier the Babylonians and Egyptians had documented epilepsy but attributed it to divine or demonic causes. Hippocrates was the first to describe epilepsy as a brain disorder rejecting the belief that it was caused by supernatural forces. This laid the foundation for modern understanding of epilepsy as a medical condition.

An epileptic seizure is a transient occurrence of signs and symptoms due to abnormal excessive or synchronous neuronal activity in the brain. Epilepsy is a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures and by the neurobiological cognitive psychological and social consequences.

According to the International League Against Epilepsy ILAE at least two unprovoked seizures occurring more than 24 hours apart or one seizure with a high risk of recurrence or a diagnosis of an epilepsy syndrome is considered epilepsy.

Epilepsy affects over 50 million people worldwide. Sudden unexpected death in epilepsy SUDEP accounts for 8 to 17 percent of epilepsy-related deaths.

Homeopathy aims to identify and remove both exciting and maintaining causes to treat epilepsy holistically. Medicines are administered in minimum doses and selected based on a detailed symptom picture.

Hahnemann emphasized individualization over disease naming. Saxton argued epilepsy is a result of deep miasmatic disturbance. Ramakrishnan noted allopathic medicine provides palliation not cure while homeopathy may bring about deep constitutional change.

Hahnemann stated miasms are inherited and do not spread solely via contact. He identified congenital miasms in syphilis gonorrhea and Psora which he believed nearly everyone carries.

Roberts highlighted miasms as destructive forces causing mental and physical illness. Hahnemann insisted that identifying the exciting cause and chronic history is essential to find the fundamental cause usually miasmatic.

In ICD-11 epilepsy is classified under code 8A60.

Classification and Causes

Classification:

FOCAL

Awareness/Impaired Awareness

Motor Onset:

Automatisms

Atonic

Clonic

Epileptic Spasm

Hyperkinetic

Myoclonic

Tonic

Non-Motor Onset:

Autonomic

Behavior Arrest

Cognitive

Emotional

Sensory

Other:

Focal to Bilateral Tonic Clonic

GENERALIZED

Motor:

Tonic-Clonic

Clonic

Tonic

Myoclonic

Myoclonic Tonic-Clonic

Myoclonic Atonic

Atonic

Epileptic Spasm

Non-Motor (Absence):

Typical

Atypical

Myoclonic

Eyelid Myoclonia

UNKNOWN

Motor:

Tonic-Clonic

Epileptic Spasm

Non-Motor:

Behavior Arrest

Unclassified



Causes of Epilepsy :

Idiopathic: 66%

Vascular disease: 11%

Congenital: 8%

Trauma: 5%

Tumors: 4%

Neurodegenerative disease: 3%

Infectious disease: 3%

Clinical Features

Focal Seizure
Impaired consciousness
Blank stare blinking lip smacking clothes picking
Postictal drowsiness bizarre behavior motor activity

Generalized Tonic-Clonic Seizure
Sudden loss of consciousness
Tonic phase body becomes rigid breathing stops
Clonic phase rapid jerking incontinence salivation
Postictal confusion headache drowsiness

Absent Seizure
Short lapse of consciousness lasting 10–30 seconds
Staring loss of tone multiple times a day

Myoclonic Seizure
Rhythmic jerking of limbs or trunk

Clonic Seizure
Alternating muscle contractions and relaxation

Tonic Seizure
Sustained muscle contraction

Atonic Seizure
Sudden loss of posture common in children

Diagnosis

Blood tests
EEG
CT scan
MRI
PET
SPECT
Neuropsychological tests
MEG

Homeopathic Approach

Epilepsy as a chronic miasmatic disorder needs holistic care. Homeopathy based on similia similibus curentur addresses both symptoms and root causes through constitutional treatment.

Homeopathy requires detailed case-taking considering history symptoms and inherited tendencies. Medicines are selected based on physical mental and emotional characteristics and miasmatic influences.

In new cases without long-term allopathic use homeopathy has shown strong potential. It is safe across age groups and free of side effects when prescribed correctly.

Miasmatic Correlation

Psoric epilepsy - Functional overactivity emotional triggers hypersensitivity
Sycotic epilepsy - Suppressed infections hormonal issues structural lesions
Syphilitic epilepsy - Degenerative neurological decline inherited disorders

Most cases have mixed miasmatic origins needing customized long-term treatment.

Thorough evaluation including seizure type aura triggers and systemic factors is essential. Success depends on remedy selection aligned with miasmatic and constitutional profile.

6.3 OBJECTIVES OF STUDY

1 To assess the role of homeopathic medicines selected through the miasmatic approach in epilepsy
2 To identify predominant miasm associated with epilepsy
3 To assess changes in severity and frequency of seizures before and after miasmatic treatment

7 MATERIALS AND METHODS

7.1 SOURCE OF DATA
OPD of C D Pachchigar Homeopathic College and Hospital, peripheral centers and regular camps. Case taking as per aphorisms 83 to 104 from Organon of Medicine.

7.2 MATERIAL
Textbooks like API and Davidson’s Principles and Practice of Medicine, Organon of Medicine, Materia Medica, repertory, related software and resources

7.3 METHOD OF COLLECTION OF DATA
Study type: Experimental
Study design: Prospective
Population: Patients from C D Pachchigar Homoeopathic Hospital and peripheral OPDs
Sample size: 30 patients
Sampling technique: Non-probability purposive sampling
Duration: 9 months

Inclusion Criteria
1 Diagnosed epilepsy cases
2 Age 2 years and above
3 All socioeconomic status
4 Both sexes

Exclusion Criteria
1 Non-compliant or unreliable patients
2 Pregnant or lactating women
3 Children below 2 years
4 Surgical epilepsy cases
5 Severe psychiatric or progressive neurological disorders

Data Analysis
Improved: Marked clinical reduction in symptoms
Not Improved: No significant changes
Left Treatment: Patients who discontinue follow-up before advised

7.4 INVESTIGATIONS REQUIRED
Diagnosis will be based on clinical history. Special investigations will be done if needed.

7.5 ETHICAL CLEARANCE
Yes

8 BIBLIOGRAPHY

1 Epilepsy Society https://epilepsysociety.org.uk
2 Hippocrates The Sacred Disease https://classics.mit.edu/Hippocrates/sacred.html
3 API Textbook of Medicine 12th Edition
4 Hahnemann S Organon of Medicine 6th Edition
5 Saxton J Miasms as Practical Tools
6 Ramakrishnan AU Homeopathic Approach to Cancer
7 Hahnemann S The Chronic Diseases
8 Roberts HA Principles and Art of Cure by Homoeopathy
9 WHO International Classification of Diseases ICD-11 https://icd.who.int/en
10 Davidson’s Principles and Practice of Medicine 24th Edition


 
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