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CTRI Number  CTRI/2025/07/091190 [Registered on: 18/07/2025] Trial Registered Prospectively
Last Modified On: 12/02/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Effect of exercises on fatigue and exhaustion in young collegiate adults 
Scientific Title of Study   Effect of Brain Gym exercises on fatigue and burnout in young collegiate adults- A Randomized Controlled Trial 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Sachin Gupta 
Designation  Assistant Professor  
Affiliation  Galgotias University 
Address  ROOM NO. B228, DEPARTMENT OF PHYSIOTHERAPY, GALGOTIAS UNIVERSITY, PLOT NO. 2, YAMUNA EXPY, OPPOSITE BUDDHA INTERNATIONAL CIRCUIT, SECTOR 17A, GREATER NOIDA, UTTAR PRADESH, INDIA

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  09015193829  
Fax    
Email  sachinguptapt3@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Shagun Agarwal 
Designation  Dean and Professor 
Affiliation  Galgotias University 
Address  ROOM NO. B512A, Dean Office, School of Allied Health Sciences, GALGOTIAS UNIVERSITY, PLOT NO. 2, YAMUNA EXPY, OPPOSITE BUDDHA INTERNATIONAL CIRCUIT, SECTOR 17A, GREATER NOIDA, UTTAR PRADESH, INDIA

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  09910259583  
Fax    
Email  dean.sahs@galgotiasuniversity.edu.in  
 
Details of Contact Person
Public Query
 
Name  Dr V Krishna Reddy 
Designation  Professor 
Affiliation  Galgotias University 
Address  ROOM NO. B320, DEPARTMENT OF PHYSIOTHERAPY, GALGOTIAS UNIVERSITY, PLOT NO. 2, YAMUNA EXPY, OPPOSITE BUDDHA INTERNATIONAL CIRCUIT, SECTOR 17A, GREATER NOIDA, UTTAR PRADESH, INDIA

Gautam Buddha Nagar
UTTAR PRADESH
203201
India 
Phone  07799233734  
Fax    
Email  krishnareddympt@gmail.com  
 
Source of Monetary or Material Support  
NIL 
 
Primary Sponsor  
Name  Galgotias University  
Address  Plot No 2 Yamuna Expy opposite Buddha International Circuit Sector 17A 
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Sachin Gupta  Galgotias University  E-003 Physiotherapy OPD Department of Physiotherapy Galgotias University Greater Noida -203102
Gautam Buddha Nagar
UTTAR PRADESH 
9015193829

sachinguptapt3@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Departmental Research Committee Galgotias University Uttar Pradesh  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  NA 
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Brain Gym exercise protocol for fatigue and burnout  Owl Movement Arm Activation Movement Grounder Movement Gravity Glider Movement  
Comparator Agent  Control Group exercise protocol for fatigue and burnout   Neck Rotation Hand Tapping Palm Press Forward trunk Bending  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  25.00 Year(s)
Gender  Both 
Details  Both male and female
Participants must be collegiate young adults aged between 18 and 25 years.
BMI: 18.5 to 24.9
Must be currently enrolled as full-time undergraduate students at a recognized university or college.
Must be willing to provide informed consent and commit to the full duration of the intervention on and evaluation process.
 
 
ExclusionCriteria 
Details  Any history of trauma, fracture, or surgery past 6 months.
Any history of neurological disorder—stroke, and traumatic brain injury (TBI) past 6 months.
Any orthopedic disorder and deformities involving the lumbar spine, pelvis, and lower extremities past 6 months.
History of doing Brain GYM past 6 months.
Any history of migraine headache or diagnosed with a psychological condition, or having a history of neurosurgery or cognitive damage, or psychotropic medication.
 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Other 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Fatigue The Multidimensional Fatigue Symptom Inventory – Short Form (MFSI-SF) Burnout: Oldenburg Burnout Inventory (OLBI),   Baseline to 4 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
NA  NA 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   30/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Closed to Recruitment of Participants 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Fatigue and burnout have emerged as significant psychosocial concerns among young collegiate adults, driven by academic pressure, lack of physical activity, disrupted sleep patterns, and social stressors (Márquez et al., 2020). Fatigue is defined as a persistent state of physical and mental exhaustion that impairs daily functioning, while burnout is characterized by emotional exhaustion, reduced personal accomplishment, and depersonalization (Maslach & Leiter, 2016). The growing prevalence of these conditions in university students has led to increased interest in non-pharmacological and holistic interventions aimed at enhancing physical and mental well-being.

Brain Gym is a movement-based educational program that includes a series of simple exercises designed to improve cognitive functions such as focus, memory, coordination, and emotional regulation (Dennison & Dennison, 1989). These exercises are theorized to integrate brain hemispheres and stimulate neural pathways, thereby enhancing energy levels and reducing psychological stress. Preliminary studies suggest that Brain Gym activities may positively impact academic performance, mood, and stress levels (Rege et al., 2021), though empirical validation in the context of fatigue and burnout in collegiate populations remains limited.

Aim: This study aims to find out the effect of Brain Gym exercises on levels of fatigue and burnout in young collegiate adults.

Need for study: Despite the popularity of Brain Gym exercises in educational and therapeutic contexts, the evidence supporting their impact on fatigue and burnout is largely anecdotal or derived from studies with methodological limitations. Most existing research focuses on children or individuals with learning difficulties, with limited randomized controlled trials assessing its effectiveness among healthy young adults (Thomas & Thomas, 2018). Furthermore, there is a dearth of rigorous, outcome-based research targeting fatigue and burnout specifically within collegiate populations, who are at a heightened risk of these conditions due to lifestyle and academic stressors (Zhao et al., 2022).

Objectives: To determine the effect of Brain Gym exercises on levels of fatigue and burnout in young collegiate adults.

 

HYPOTHESIS

 

Alternative hypothesis: There will be a significant effect of Brain Gym exercises on levels of fatigue and burnout in young collegiate adults.

 

Null hypothesis: There will be no significant effect of Brain Gym exercises on levels of fatigue and burnout in young collegiate adults.

 
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