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CTRI Number  CTRI/2025/07/091039 [Registered on: 16/07/2025] Trial Registered Prospectively
Last Modified On: 15/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Effectiveness of Bells Diarrhoea and Boericke Repertory in treatment of Acute Gastroenterities 
Scientific Title of Study   A Comparative Study To Determine Bells Diarrhoea And Boericke Repertory Effectiveness in Acute Gastroenterities 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Bhavna Dinesh Rawal 
Designation  MD Scholar Part 2 
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  Department of Case Taking and Repertory Division of MD 2nd Floor C D Pachchigar College of Homoeopathic Medicine and Hospital Near Anand Mangal Society Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  6351201808  
Fax    
Email  bhawanarawal190@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Niloufer Pachchigar 
Designation  Professor of Case Taking and Repertory Department 
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  Department of Case Taking and Repertory Division of MD 2nd Floor C D Pachchigar College of Homoeopathic Medicine and Hospital Near Anand Mangal Society Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9925556888  
Fax    
Email  drpachchigar@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Niloufer Pachchigar 
Designation  Professor of Case Taking and Repertory Department 
Affiliation  C D Pachchigar College of Homoeopathic Medicine and Hospital 
Address  Department of Case Taking and Repertory Division of MD 2nd Floor C D Pachchigar College of Homoeopathic Medicine and Hospital Near Anand Mangal Society Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9925556888  
Fax    
Email  drpachchigar@gmail.com  
 
Source of Monetary or Material Support  
Bells Diarrhoea Repertory 
Boericke Repertory 
Books of Organon of Medicine, Materia medica, Repertory, all Homoeopathic books and literature related to my topic, software and soft or hard research material  
C D Pachchigar College of Homoeopathic Medicine and Hospital Near Anand Mangal Society Udhana Magdalla Road Surat 395010 Gujarat India 
Case performa prepared for C D Pachchigar General Hospital O.P.D and I.P.D 
Homoeopathic Computerized Software 
Repertorial sheet 
 
Primary Sponsor  
Name  C D Pachchigar College of Homoepathic Medicine and Hospital 
Address  C D Pachchigar College of Homoepathic Medicine and Hospital Near Anand Mangal Society Udhana Magdalla Road Surat 395001 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Bhavna Dinesh Rawal  C D Pachchigar Coleege of Homoeopathic Medicine and Hospital   Department of Case taking and Repertory Division of MD 2nd Floor C D Pachchigar Coleege of Homoeopathic Medicine and Hospital near Anand Mangal Society Udhana Magdalla road Surat 395001
Surat
GUJARAT 
6351201808

bhawanarawal190@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee of C D Pachchigar College of Homoeopathic Medicine and Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: A09||Infectious gastroenteritis and colitis, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Homoeopathic medicine based on the Bells Diarrhoea Repertory Repertorization will be given to another group  Cases where Bells Diarrhoea Repertory is indicated and based on the repertorization process medicine well indicated will be given to the patient of another group with the Doses as per requirement of the case and the duration of doses of medicine to be given to the patient will be based on the doses required for curing the case within the period of 9 months  
Intervention  Homoeopathic medicine will be given based on the repertorization process worked wilh the healp of Boericke Repertory will be given to one group   Cases where Boericke Repertory is indicated and based on the repertorization process medicine well indicated will be given to the patient of one group with the dose as per requirement of the case and the duration of doses of medicine to be given to the patient will be based on the doses required for curing the case within the period of 9 months 
 
Inclusion Criteria  
Age From  0.00 Year(s)
Age To  99.00 Year(s)
Gender  Both 
Details  Cases with Acute Gastroenterities will be selected irrespective of the age and gender  
 
ExclusionCriteria 
Details  Patient suffering from any Congenital Anomalies
Cases with Advance pathological condition
Patient with irregular follow up
Who left the treatment 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To study the Effectiveness of Boericke Repertory and Bells diarrhoea Repertory in cases of Acute Gastroenterities  within 1 to 2 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
To learn the rubrics related to Acute Gastroenterities from both Bells Diarrhoea and Boericke Repertory  within the time Period of 9 months 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 3 
Date of First Enrollment (India)   31/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

NEED FOR THE STUDY:

Acute Gastroenteritis is the condition where there is inflammation and irritation into the stomach and intestine which cause symptoms such as abdominal cramps, nausea, vomiting, and diarrhea. These can be due to viral, bacterial, parasitic or fungi infection which leads to Gastroenteritis.

Nowadays, Acute Gastroenteritis is considered to be the most problematic disease among the population, which increase the mortality and morbidity of the patients. The Centers for Disease Control and Prevention (CDC) estimate, there are more than 350 million cases of acute gastroenteritis in the united states annually and 48 million of these cases are caused by food-borne bacteria. Traveler’s diarrhea affects more than half of people travelling from developed countries to developing countries. In adult and pediatric patients, the prevalence of Clostridium difficle is increasing. Contact precautions, public health education are necessary goals in decreasing the prevalence of Clostridium difficle. (1)

According to WORLD HEALTH ORGANISATION (WHO) stats that: Diarrheal disease is the third leading cause of death in children 1-59 months of age. It is both preventable and treatable. Each year diarrhea kills around 443832 children under 5 and an additional 50851 children aged 5 to 9 years. Globally, there are nearly 1.7 billion cases of childhood diarrheal disease every year. Diarrhea is the leading cause of malnutrition in children under 5 years old. (2)

According to a 2019 study, ROTAVIRUS causes an estimated 11.37 million cases of Acute gastroenteritis (AGE) in children under five years old in India each year. Rotavirus can also cause an estimated 122000-153000 deaths and 457000-884000 hospitalizations in children under five each year. In October 2022, the CDC found that acute diarrhea had a higher prevalence among people aged 18-44 (10.2%) and 5-17 (3.3%) than among the people aged 0-4 (7.8%). (5)

Boericke repertory and Bell’s diarrhea repertory is the repertory which can be used in the case of gastroenteritis, due to their construction of repertory.

Boericke repertory has well-arranged rubric for the symptoms of gastroenteritis, in the format of occurrence, type, during, after, associated symptoms etc. Boericke repertory is the clinical repertory.

While Bell’s diarrhea repertory has well-arranged rubrics related to the diarrhea in every aspect related location, sensation, modalities and concomitant. Bell’s diarrhea repertory is the regional repertory.

Therefore, need for study these repertories for Acute gastroenteritis, is to know the effectiveness of Boericke’s repertory and Bell’s diarrhea in cases of Acute Gastroenteritis as a comparative study.

ACUTE GASTROENTERITIS

DEFINITION

·         Acute gastroenteritis presents as profuse diarrhea with associated nausea, vomiting with or without abdominal discomfort.

·         By Definition “diarrhea means passage of 3 or more loose or watery motion per 24 hrs. resulting in excessive loss of fluid and electrolytes in stool”.

·         When associated with fever and vomiting it is termed “acute gastroenteritis”.

·         WHO/UNICEF definition of acute diarrhea – acute diarrhea is an attack of sudden onset, which lasts usually for 3- 7 days but may last up to 10 – 14 days, caused by infection of the bowel. (4)

Factors that increase the susceptibility to the disease:  (10)

·         Young age

·         Immune deficiency

·         Measles

·         Lack of breastfeeding

·         Ingestion of contaminated food and water

·         Poor hygiene

·         Ignorance

·         Overcrowding

·         Poverty

CLINICAL MANIFESTATIONS

·         Diarrhea

·         Cramps

·         Emesis

·         Fever

·         Malaise

·         Seizures

INVESTIGATIONS

Laboratory studies to identify the pathogen are not required as most of the episodes are self-limiting. Only when the child is not responding to the standard treatment a stool culture is indicated. Stool specimen should be examined for mucus, blood and leucocytes, the presence of which indicates colitis. In cases of severe dehydration, serum electrolytes, BUN, serum creatinin should be done to assess the kidney function and to plan the fluid therapy

 

MANAGEMENT (3) (12)

 

Management of dehydration remains the cornerstone of therapy of diarrhea according to the severity of dehydration.

OBJECTIVE  OF  THE  STUDY :

 

1.    To show the effectiveness of Bell’s diarrhea repertory and Boericke’s repertory in Acute Gastroenteritis.

2.    To do a comparative study of Boericke’s repertory (Clinical repertory) and Bell’s diarrhea repertory (Regional repertory) in Acute Gastroenteritis.

material  and  methods :

SOURCES  OF  DATA :

·         PROJECT SITE

1.    OPD & IPD of C. D. Pachchigar College of Homoeopathic Medicine & Hospital; Near Navjivan Circle, Udhana Magdalla Road, Surat. 395001

2.    Peripheral OPDs

MATERIALS :

·         Case Performa prepared for C. D. Pachchigar General Hospital - OPD Performa

·         Boericke’s repertory

·         Bell’s diarrhea repertory

·         Materia medica of homoeopathic medicines by Dr. William Boericke.

·         Homoeopathic computerized software: CARA PRO.V.4.5, and other homoeopathic software.

·         All literature of Homeopathy and Allied science which required for my study.

METHOD  OF  COLLECTION  OF  DATA :

·         STUDY DESIGN – Prospective Analytical Study

·         STUDY POPULATION – 100 cases of Gastroenteritis, which will be treated with the help of Bell’s diarrhoea and Boericke’s repertory.

·         SAMPLE SIZE – 30 CASES

·         SAMPLING TECHNIQUES - Simple Random Sampling

·         STUDY DURATION – 9 months

·         SELECTION CRITERIA 

Inclusion Criteria

1.    Both sex

2.    All age groups predominant

3.    Cases of Acute Gastroenteritis

 

Exclusion Criteria

1.    Patient suffering from any Congenital Anomalies.

2.    Cases with advance pathological condition.

 

Withdrawal Criteria

1.    Patient with irregular follow up.

2.    Who left the treatment

 

·         Patient will be selected on basis of Inclusion & Exclusion Criteria, history & clinical findings.

·         Case taking will be done according to guidelines given in Aphorisms 83-104 by

 Dr. Hahnemann.

·         Repertorization will be done by using Bell’s diarrhea and Boericke’s Repertory.

·         Remedy will be selected on the basis of repertorial result obtained by using Bell’s diarrhea and Boericke’s Repertory and differentiated from different Materia Medica.

·         The remedies will be used in various potencies as per the requirement of the case.

·         The remedies will be repeated as per the requirement of the case.

·         The follow-up of case will be taken as per the requirement.

 

Response will be analyzed according to following 3 Criteria _

1.    SIGNIFICANT IMPROVEMENT – Sense of wellbeing with no presenting complaints and no relapse of the symptoms for more than 3 months

2.    IMPROVEMENT – Patient relieved from presenting complaints with decrease in intensity.

3.    NO IMPROVEMENT – Patient who didn’t get relief in spite of giving medicine at regular intervals.


 
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