| CTRI Number |
CTRI/2025/07/091253 [Registered on: 21/07/2025] Trial Registered Prospectively |
| Last Modified On: |
14/07/2025 |
| Post Graduate Thesis |
Yes |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Randomized, Parallel Group, Active Controlled Trial |
|
Public Title of Study
|
Comparing Nerve Exercises and Standard Therapy to Reduce Pain and Improve Hand Strength in People with Carpal Tunnel Syndrome |
|
Scientific Title of Study
|
Effect of Neural Mobilization Versus Conventional Therapy In Improving Pain and Strength in Carpal Tunnel Syndrome |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| nil |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Adnaan Ahmad |
| Designation |
Post Graduate Student |
| Affiliation |
Shri Guru Ram Rai University School of Paramedical And Allied Health Sciences |
| Address |
Shri Mahant Indresh Hospital Department of Physiotherapy North Block Basement
Dehradun
UTTARANCHAL
248001
India |
| Phone |
9389805789 |
| Fax |
|
| Email |
addyyhashmi.doon@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr. Shama Parveen (PT) |
| Designation |
Assistant Professor |
| Affiliation |
Shri Guru Ram Rai University School of Paramedical And Allied Health Sciences |
| Address |
Shri Mahant Indresh Hospital Department of Physiotherapy North Block Basement
Dehradun
UTTARANCHAL
248001
India |
| Phone |
8006965111 |
| Fax |
|
| Email |
shamaparveen@sgrrmc.com |
|
Details of Contact Person
Public Query
|
| Name |
Adnaan Ahmad |
| Designation |
Post Graduate Student |
| Affiliation |
Shri Guru Ram Rai University School of Paramedical And Allied Health Sciences |
| Address |
Shri Mahant Indresh Hospital Department of Physiotherapy North Block Basement
Dehradun
UTTARANCHAL
248001
India |
| Phone |
9389805789 |
| Fax |
|
| Email |
addyyhashmi.doon@gmail.com |
|
|
Source of Monetary or Material Support
|
| Shri Guru Ram Rai University , School of Paramedical and Allied Health Sciences, Pathribagh Dehradun, Uttarakhand,248001 |
|
|
Primary Sponsor
|
| Name |
Adnaan Ahmad |
| Address |
Shri Guru Ram Rai University , School of Paramedical and Allied Health Sciences, Pathribagh Dehradun, Uttarakhand,248001 |
| Type of Sponsor |
Other [[ Self ] ] |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Adnaan Ahmad PT |
Shri Mahant Indresh Hospital, Department Of Physiotherapy |
North Block Basement
Dehradun
UTTARANCHAL |
09389805789
addyyhashmi.doon@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Institutional Ethics Committe (IEC) Shri Guru Ram Rai Institute of Medical and Health Sciences |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M00-M99||Diseases of the musculoskeletal system and connective tissue, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Conventional Physiotherapy |
Participants in the control group received conventional physiotherapy, including TENS (15–20 mins), cryotherapy (8–10 mins), wrist splints, and grip strengthening with a squeeze ball (3 sets of 10 reps). Each session lasted around 45 minutes, provided 5 days per week for 6 weeks. Pre- and post-treatment assessments using DASH and VAS scales were done to evaluate pain and grip strength improvements. |
| Intervention |
Neural Mobilization Therapy |
Participants receive neural mobilization techniques performed in a supine position, involving controlled cervical and upper limb movements to mobilize the median nerve. Each session lasts for approximately 45 minutes, administered 5 days per week for 6 weeks. DASH and VAS scores are used to monitor pre- and post-intervention outcomes. |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
60.00 Year(s) |
| Gender |
Both |
| Details |
inclusion criteria-Participants aged 18 to 60 years, of either gender, diagnosed with mild to moderate carpal tunnel syndrome with symptom onset within the last 6–8 weeks were included. Eligible participants presented with numbness or paresthesia in the affected hand, positive Phalen’s and Tinel’s tests, and no excessive upper limb pain as measured by the Visual Analogue Scale (VAS). |
|
| ExclusionCriteria |
| Details |
Participants were excluded if they were non-cooperative, had a history of upper limb fracture, had undergone unsuccessful surgical treatment for CTS, or had untreated inflammatory or metabolic disorders such as diabetes or thyroid disease. Individuals with recent trauma to the affected hand (within the past year) or those who were pregnant were also excluded. |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Outcome Assessor Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
| VAS and DASH scales |
Day 0 (pre-treatment)
Day 42 (post-treatment) |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Nil |
Nil |
|
|
Target Sample Size
|
Total Sample Size="30"
Sample Size from India="30"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
31/07/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="0"
Months="2"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This randomized, parallel group trial compares the effectiveness of neural mobilization versus conventional physiotherapy in improving pain and grip strength in patients with carpal tunnel syndrome.30 participants will be randomly assigned to either neural mobilization or conventional therapy (TENS,Cryotherapy,Splinting and hand exercises).Both groups will recieve 45-minute sessions,5 days a week for 6 weeks.Outcome will be measured using VAS and DASH sacles at baseline and after 6 weeks. |