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CTRI Number  CTRI/2025/07/090683 [Registered on: 10/07/2025] Trial Registered Prospectively
Last Modified On: 10/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Single Arm Study 
Public Title of Study   Undertanding How Triggers Affect Homeopathic Treatment Of Sore Throat 
Scientific Title of Study   Assessment Of Exciting Causes In Homeopathic Management Of Acute Pharyngitis 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Charmee Nitinkumar Markana 
Designation  PG Scholar 
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital 
Address  Department Of Organon Of Medicine And Homoeopathic Philosophy Division Of MD 2nd Floor C D Pachchigar College Of Homoeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  7984294134  
Fax    
Email  charmeemarkana@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Snehaben Ajitkumar Patel 
Designation  Associate Professor Of Organon Of Medicine And Homoeopathic Philosophy 
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital 
Address  Department Of Organon Of Medicine And Homoeopathic Philosophy Division Of MD 2nd Floor C D Pachchigar College Of Homoeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9428392287  
Fax    
Email  snehugopi@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Snehaben Ajitkumar Patel 
Designation  Associate Professor Of Organon Of Medicine And Homoeopathic Philosophy 
Affiliation  C D Pachchigar College Of Homoeopathic Medicine And Hospital 
Address  Department Of Organon Of Medicine And Homoeopathic Philosophy Division Of MD 2nd Floor C D Pachchigar College Of Homoeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat

Surat
GUJARAT
395001
India 
Phone  9428392287  
Fax    
Email  snehugopi@gmail.com  
 
Source of Monetary or Material Support  
C D Pachchigar College Of Homoeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat India 395001 
 
Primary Sponsor  
Name  C D Pachchigar College Of Homoeopathic Medicine And Hospital 
Address  C D Pachchigar College Of Homoeopathic Medicine And Hospital Near Navjivan Circle Udhana Magdalla Road Surat 395001 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Charmee Nitinkumar Markana  C D Pachchigar College Of Homoeopathic Medicine And Hospital  Department Of Organon Of Medicine And Homoeopathic Philosophy Division Of MD 2nd Floor
Surat
GUJARAT 
7984294134

charmeemarkana@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee Of C D Pachchigar College Of Homoeopathic Medicine And Hospital  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: J02||Acute pharyngitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Homoeopathic Medicines  Individualized Homoeopathic Medicines Will Be Prescribed On The Basis Of Totality Of Symptoms And Individual Susceptibility The Medicine Will Be Administered Orally Through Sublingual Mode Of Administration The Dose Will Be In The Form Of Medicated Globules 2 To 4 Globules Per Dose The Frequency Of Doses Will Be 3 To 6 Doses Repeated At Interval Of 1 To 6 Hours As Per Requirement Of The Case Depending Upon The Severity And Response Of The Case The Total Duration Of Intervention Will Be 2 To 7 Days Until Complete Relief Of Symptoms 
Comparator Agent  NIL  NIL 
 
Inclusion Criteria  
Age From  1.00 Year(s)
Age To  80.00 Year(s)
Gender  Both 
Details  1 Patient Having Clinical Representation Of Acute Pharyngitis
2 Patient Of All Ages And Both Sexes
3 Patient Having Specific Causative Factor For Their Illness
 
 
ExclusionCriteria 
Details  1 Patient Having Chronic Pharyngitis
2 Patient Without Specific Causative Factor For Their Illness
3 Patient Suffering From Severe Systemic Disease
4 Patient Suffering From Life Threatening Disease And Who Need Emergency Medical Intervention
 
 
Method of Generating Random Sequence   Stratified randomization 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
To Identify The Factors Or Agents That Triggers Acute Pharyngitis  9 Months 
 
Secondary Outcome  
Outcome  TimePoints 
To Understand Different Types Of Exciting Causes In Patient Suffering From Acute Pharyngitis  9 Months 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   25/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="9"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

BRIEF RESUME OF INTENDED WORK

NEED FOR STUDY

Every effect has cause behind it. Even discovery of our great science of homeopathy is based on event when our MASTER DR.HAHNEMMAN discovered the effect of cinchona bark on healthy human being while translating William Cullen Book Named A Treatise on Materia Medica from English to German in year of 1790. Then he searched for the cause and he discovered the principle of homeopathy i.e. law of similia. Likewise, many discoveries have been done in search for causes irrespective of medical field i.e. the Discovery of Newtonian law by falling of an apple. You may ask why we have to investigate for cause in every disease especially exciting cause? Because an illness can represents itself by a perceptible sign and symptoms although the internal deranged nature is hidden within the man. As in homeopathy we give great importance to origin of melody and characteristic features of an individual in the treatment of disease. So, by identifying an exciting cause and understanding its value in treatment of disease helps a man to heal.

Now, what are these factors responsible for man in disease and how they affect man? As we know that an individual is made up of two parts:

1.The Inner man and

2.The Outer man

The Inner man is our vital force including his hereditary miasms, diathesis etc. While the outer man is made up of his own external surroundings, life styles etc. In healthy condition of man, these outer man and inner man is interconnected to each other. The exogenous factors which triggers illness in healthy person by onset of signs and symptoms named as exciting cause as mentioned in aphorism no.5 of Organon of Medicine. Yet, these exciting cause not produce disease directly but it produce disease on response of an individual to his external environment which leads to derangement of vital force.

Yes, one may think that how they help homeopathic physician in prescription especially in acute ones? Now, these derangement of vital force otherwise if not treated with homeopathic medicine may cause injuries effect to life of patient i.e. acute condition may progress to chronic disease in patient. Additionally, these exciting causes are one of the components of complete symptoms which when strong and peculiar, helps in selection of remedy. Therefore, if we treat the patient by considering these factors in our prescription, it will restore the disease of patient from sick to health. So, it is most important for homeopathic physician to be aware about these type of causes which can disturb the health of patient and make them sick.

Pharyngitis is the inflammation of mucus membrane from various aetiological factors i.e. bacteria, virus etc. Pharyngitis is the most common disorder in adults and children, with more than 10 million ambulatories visits per year. Viruses are most common causes of pharyngitis and accounts for 25 to 45 percentages of all cases. Poor housing conditions and indoor pollution contribute to the increased prevalence of sore throat.

Homeopathic treatment of pharyngitis based on treating the patient as a whole by enquiring into factors affecting the individual i.e. food, climate, etc. In most of cases, these external factors troubling the patients with pharyngitis and let him come to physician. As a Homeopathic physician our duty is to find out an exciting cause in individual in every cases of pharyngitis in order to heal patient from within not only by considering only external manifestation of disease but also enquiring the underlying cause of a disease. These serves holistic healing to every pharyngitis patients.

REVIEW OF LITERATURE

DEFINITION OF PHARYNGITIS

Pharyngitis is defined as the inflammation of the pharynx, hypopharynx, uvula and tonsils.

EPIDEMIOLOGY 

Pharyngitis is the most common disorder in adults and children, with more than 10 million ambulatories visits per year.

Viruses are most common causes of pharyngitis and accounts for 25 to 45 percentages of all cases.

TYPES

ACUTE PHARYNGITIS

AETIOLOGY

Viral: Rhinovirus, Influenza, Measles and chicken pox, Infectious mononucleosis.

Bacterial: Group A beta haemolytic streptococcus, Diphtheria.

Fungal: Candida albicans, Monilia.

CLINICAL FEATURES

It may occurs in different grades of severity.

Milder infection: Discomfort in throat, malaise and low grade fever. Pharynx is congested but there is no lymphadenopathy.

Moderate and severe infection: Pain in throat, dysphagia, headache, malaise, high fever. Pharynx shows erythema, exudate, enlargement of tonsils and lymphoid follicles on posterior pharyngeal wall.

Very severe infection: oedema of soft palate and uvula with enlargement of cervical lymph nodes.

CHRONIC PHARYNGITIS

It is a chronic inflammatory condition of the pharynx. Pathologically, it is characterised by hypertrophy of mucosa, seromucinous glands, sub epithelial lymphoid follicles and even the muscular coat of the pharynx.

AETIOLOGY

A large number of factors are responsible:

Persistent infection in neighbourhood: ex. Chronic rhinitis, etc.

Mouth breathing: It includes nasal polypi, adenoids, etc.

Chronic irritants: excessive smoking, chewing of tobacco and pan, etc.

Environmental pollution: irritant industrial fumes, etc.

Faulty voice production: excessive use of voice in certain professionals.

CLINICAL FEATURES

Severity of symptoms in chronic pharyngitis varies from person to person.

Discomfort or pain in throat.

Foreign body sensation in throat.

Tiredness of voice

Cough

Congestion of posterior pharyngeal wall.

Uvula become elongated and appear oedematous.

DIAGNOSIS OF PHARYNGITIS

Clinical features and physical examination of oral cavity is useful for diagnosing pharyngitis.

TREATMENT

In every case of chronic pharyngitis, aetiological factor should be sought and eradicated.

Voice rest and speech therapy is essential for those with faulty voice production.

Hawking, clearing the throat frequently or any other such habit should be stopped.

Warm saline gargles, especially in the morning, are soothing and relieve discomfort.

VIEW OF MASTER HAHNEMANN ON CAUSE OF DISEASE

According to Master Hahnemann, there are three causes of diseases:

1.Exciting cause

2.Fundamental cause

3.Maintaining cause

In which, he mentioned exciting and fundamental cause in aphorism 5 and maintaining cause in aphorism 7 in organon of medicine.

THE EXCITING CAUSE:

APHORISM 5: Useful to the physician in assisting him to cure are the particulars of the most probable exciting causes of the acute diseases, as also the most significant points in the whole history of the chronic disease, to enable him to discover its fundamental cause, …are to be taken into consideration.

It can be defined as the cause that excites disease condition, either acute disease or acute exacerbation of chronic diseases.

Master Hahnemann in aphorism 73 gives examples of exciting causes:

APHORISM 73: As regards acute diseases, they are either of such a kind as attack human beings individually, the exciting causes being injurious influences to which they were particularly exposed. Excesses in food, or an insufficient supply of it, severe physical impressions, chills, overheatings, dissipation, strains, etc., or physical irritations, mental emotions, and the like, are the exciting causes of such acute febrile affections,…the Asiatic cholera, etc.

TYPES OF EXCITING CAUSE

Physical: Physical and environmental conditions like exposure to excess heat or cold, thunderstorm, intake of excess or lack of food, etc.

Mechanical: Damages caused by physical trauma. Ex: injuries, accidents, burns and insect bites, etc.

Nervous: Psychological reasons like fear, shock, jealousy, grief and over joy etc.

Hygienic: Food poisoning, pollution and lack of personal and social hygiene.

IMPORTANCE OF EXCITING CAUSE

1.Helps in selecting medicine both in acute and chronic diseases.

2.The proper understanding of exciting cause also helps to avoid those influences in future.

3.Removal of exciting cause helps to restore health in Indisposition.

REVIEW OF STALWARTS

J.T.KENT: According to Dr. Kent, the probable exciting cause is the inflowing of the cause as an invisible, immaterial substance, which flows from centre to outer economy. Acute diseases exist from specific cause and their influences might exist in atmosphere.

There are many stalwarts like Dr. H. A. Robert, Dr. Stuart close, Dr. C. M. Boger etc. also gives some idea about exciting cause.

OBJECTIVES OF STUDY

1.To identify the factors or agents that triggers acute pharyngitis.

2.To understand different types of exciting causes in patient suffering from acute pharyngitis.

MATERIAL AND METHODS

SOURCE OF DATA

Project site:

O.P.D. and I.P.D. of C.D.Pachchigar College of Homeopathic Medicine and Hospital, Near Navjivan Circle, Udhana Magdalla Road, Surat.

Peripheral centre O.P.D. allotted by C.D.Pachchigar College of Homeopathic Medicine and Hospital, Near Navjivan Circle, Udhana Magdalla Road, Surat.

MATERIAL

Materials utilized in study consist of:

Standard case taking format of C.D.Pachchigar College of Homeopathic Medicine and Hospital, Near Navjivan Circle, Udhana Magdalla Road, Surat.

Homeopathic computer software : RADAR OPUS 3.3.24, COMPLETE DYNAMICS and other homeopathic softwares. 

Books: All homeopathic and allied literature and source books related to my topic.

Websites, Articles and Journals (if any)

Any Software for Statistical Analysis, if required.

Data analysis:

Case taking will be done according to guidelines of Master Hahnemann as per case record format.

After proper analysis and evaluation, totality of symptoms will be formed including specific causation.

Selection of remedy will be done on bases of totality of symptoms either from repertorial or non repertorial approach.

Selection of potency and repetition will be done as per requirement of case.

Administration of remedy will be done according to guidelines given by Dr. Hahnemann in organon of medicine.

The follow up of cases will be taken as per requirement of cases.

Response will be analysed into following criteria:

Significance improvement: Sensation of general well being of patient physically and mentally with disappearance of all the symptoms.

Mild improvement: Decrease in intensity or severity of symptoms with general wellbeing of patient.

Not improved: No change in presenting complain.

 
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