| Ayurveda is an ancient science which deals with the health of human being. The main aim of Ayurveda is to maintain the health of well being/healthy person and cure the diseased one. (4) Shalyatantra is one part of ashtang Ayurveda.(2) Acharya sushruta has given the first placed to Vrana in shalyatantra which is mentioned in sutrasthana and chikitsasthana.
On the basis of occurrence of Vrana it is divided into two parts(4) 1.Nij vrana-Due to vitiated dosha 2.Agantuj Vrana-Due to external factors/Trauma/Burns. In modern science, Vrana can be compared with ulcer or wound. According to modern science, Wound i s a discontinuity o r break i n the surface of epithelium. (5l As a clean wound heals naturally by the body tendency with primary intention within minimum time period. When the clean wound get contaminated by foreign body or certain conditions which hampers wound healing like exposure to radiation, immune deficiency, anemia, DM, Uremia, malignancy even due to presence of dead tissue which may infect the wound 6l. And if this Vrana remains untreated for longer time it can converted into Dushta Vrana. In Sushrut Samhita clinical features of dushta vrana are- Atisamvrutta, Ativivrutta, Atikathin, Atimrudu, Utsana, Atisheet, Atyushna, Krishn, Peeta, Rakt,Shukladi varnas, puyayukt , unmargiutsangi,vivrutagandhi Atyarthavedana, daha rag, pak, kandu, shoph,dushtashonitastravi and deerghkalanubandhi.l? If t h e infected wound n o t treated properly i t may causes complications like putrefying pus discharge,severe pain,suppuration,swelling, itching, redness which might remains for longer period and are difficult to heal. In Ayurveda Acharya Sushruta had explained management of Vrana as the shashtiupakrama in chikitsasthana. 8J It includes shodhan and ropan upkram,Shodhan which helps to remove foreign body and slough due to which wound get pure and along with these Ropan karma helps to heal the wound and preserve the normal integrity of skin. Foot ulcers are one of the main complications in diabetes mellitus,with a 15% lifetime risk in all diabetic patients. Sushruta mentioned the variety of upkrama to manage the wound, snehan is one among them. Aacharya Vagbhat mentioned ’Patoladi Ghruta’ a s in the management of vrana in Ashtangsangraha. The present research topic entitled as " RANDOMIZED CLINICAL TRIAL TO ASSESS EFFICACY OF PATOLADI GRUTA IN COMPARISON WITH JATYADI GHRUTA IN THE MANAGEMENT OF DUSHTA VRANA WITH SPECIAL REFERENCE TO DIABETIC FOOT ULCER." The contents o f Patoladi Ghruta have properties of antimicrobial, analgesics ,anti-inflammatory, Immuno modulatory which enhances wound healing. RATIONALE OF STUDY : To avoid surgical interventions like debridement of wound which is invasive and painful treatment. • Prevalence of Diabetic foot ulcer in india is 4.5%. • The patient of Dushta vrana are increasing in the society due to poor hygiene, malnutrition and decrease immunity. • To assess efficacy of Patoladi ghruta in dushta vrana w.s.r diabetic foot ulcer
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