Nausea and vomiting are very common after any major surgical procedure. Therefore, antiemetic prophylaxis is frequently used to reduce this complication and promote patient comfort. Amisulpride is being used as a treatment for post operative nausea vomiting but its use as a prophylaxis for the same is relatively less studied. The primary objective of this study is to compare antiemetic action of 5mg IV Amisulpride over 4mg IV Ondansetron as a prophylaxis given to adults undergoing General Anaesthesia for laparoscopic cholecystectomy. In this study two randomized groups “A” and “O” are allocated where Group “A’’ receives 5mg IV Amisulpride and Group “O” receives 4mg IV Ondansetron. This Prospective Randomised Double Blind Control Study will be conducted in the Department of Anaesthesia and Critical care, Central Hospital NF Railways over a period of 18 months on patients of ASA Physical status I and II aged between 25-55 years. Presence of complain of nausea and vomiting, retching, need for rescue antiemetic drug is assessed at 3h,6h,12h,24h post operatively and PONV impact scale score calculated over 24 hours. It is hypothesized that Amisulpride is better for prophylaxis of PONV as compared to Ondansetron.