| CTRI Number |
CTRI/2025/11/096838 [Registered on: 03/11/2025] Trial Registered Prospectively |
| Last Modified On: |
02/11/2025 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Yoga & Naturopathy |
| Study Design |
Randomized, Parallel Group Trial |
|
Public Title of Study
|
Yoga for Healthy Volunteers |
|
Scientific Title of Study
|
Effect of a Structured Academic Yoga Program on telomere length in
Healthy Volunteers: A Randomized Controlled Trial |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Dr A Velan |
| Designation |
PG Scholar |
| Affiliation |
International Institute of Yoga and Naturopathy Medical Sciences |
| Address |
184/4,International Institute of Yoga and Naturopathy Medical Sciences, Faculty Block (First Floor), Department of Yoga, Kamarajar Nagar, Chengalpattu, Kancheepuram
Kancheepuram
TAMIL NADU
603001
India |
| Phone |
9094525759 |
| Fax |
|
| Email |
drvelanbnys@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Dr Mahesh Kumar |
| Designation |
Assistant Medical officer |
| Affiliation |
Government Yoga and Naturopathy Medical College and Hospital, Chennai |
| Address |
Room No. 1, First Floor, Government Yoga and Naturopathy Medical College and Hospital, Chennai, 600106
Chennai
TAMIL NADU
600106
India |
| Phone |
9884591739 |
| Fax |
|
| Email |
doctor.mahesh1985@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Dr A Velan |
| Designation |
PG Scholar |
| Affiliation |
International Institute of Yoga and Naturopathy Medical Sciences |
| Address |
184/4,International Institute of Yoga and Naturopathy Medical Sciences, Faculty Block (First Floor), Department of Yoga, Kamarajar Nagar, Chengalpattu, Kancheepuram
Kancheepuram
TAMIL NADU
603001
India |
| Phone |
9094525759 |
| Fax |
|
| Email |
drvelanbnys@gmail.com |
|
|
Source of Monetary or Material Support
|
| 184/4, Kamaraj Nagar, Room No. 1, International Institute of Yoga And Naturopathy Medical Sciences, Chengalpattu. Tamil Nadu- 603001 |
|
|
Primary Sponsor
|
| Name |
Tamil Nadu Dr. M.G.R. Medical University |
| Address |
No 69, Tamil Nadu Dr. M.G.R. Medical University, Anna Salai, Guindy, Chennai - 600032. |
| Type of Sponsor |
Research institution |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr A Velan |
International Institute of Yoga and Naturopathy Medical Sciences |
184/4, International Institute of Yoga and Naturopathy Medical Sciences, Faculty Block(First Floor), Department of Yoga, Kamarajar Nagar, Chengalpattu, Kancheepuram.
Kancheepuram
TAMIL NADU |
9094525759
drvelanbnys@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| International Institute of Yoga and Naturopathy Medical Sciences,Chengalpattu, Institutional Ethics Committee |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Healthy Human Volunteers |
Healthy Individuals |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Comparator Agent |
Waitlist Control Group |
The waitlist control group will continue their usual lifestyle during the study and will be offered the same yoga program after the trial. |
| Intervention |
Yoga Protocol |
Participants in the study group will receive one hour of regular academic yoga practice from 8 am to 9 am, five days a week, for six months.
Loosening Stretches
1. Joint movements
2. Neck and shoulder exercises.
3. Eye exercises.
Asanas
1. Tadasana
2. Tiryakatadasan
3. Vrksana
4 Utthita Trikonasana
5. Parivrtta Trikonasana
6. Virabhadrasana
7. Utkatasana
8. Padangusthasana
9. Padahastasana
10. Samakonasana
11. Dwikonasana
12. Utthita lolosana
13. Dolosana
14. Ardha chakrasana
15.
Katichakrasana
16. Padamool
17. Garudasan
18. Prarambhiksthiti
19. Raju Karshanasana
20. Gatyatmakmeru vakrasana
21. Chakkichalanasana
22. Nauka
Sanchalanasana
23. Kashta
Takshanasana
24. Namaskarasana
25. Kawa chalasana
26. Udarakarashanasana
27. Gomukasana
28. Sukhasana
29. Ardha padmasana
30. Padmasana
31. Siddhasana
32. Siddhayoniasana
33. Dhyana veerasana
34. Simhasana
35. Vajrasana
36. Ananda madriasana
37. Padadhirasana
38. Bharasana
39. Veerasana
40. MarjariAsana
41. Vyagrasana
42. Shashankasan
43. Pranamasana
44. Ardha
Ushitvasana
45. Ustrasana
46. Supta Vajrasana
47. Parvatasana
48. Paschimottanasan
49. Janu Sirshasana
50. Meru Wakrasana
51. Ardhamatsyendrasana
52. Sedubandasan
53. Naukasan
54.Ardha Pawanamuktasan
55. Pawanamuktasan
56. Sedubandasana
57. Badda Padmasana
58. Yogamudrasana
59. Bhujangasana
60. Ardha Shalabasan
61. Shalabasan
62. Dhanurasan
63. Chakrasana
64. Vipareetha karni
65. Sarvangasana
66. Matsyaasana
67. Makrasana
68. Shavasana
69. Halasan
Pranayama
1.Yogic breathing
2. Nadishodhana
3. Anuloma, villoma
4. pratiloma
pranayama.
5. Ujjai Pranayama
6. Kabalabhati
7. Bhastrika
8. Sheetali
9. Sheetkari
Meditation & Relaxation
1. Mind Sound Resonance Technique
2. Deep Relaxation Technique |
|
|
Inclusion Criteria
|
| Age From |
18.00 Year(s) |
| Age To |
30.00 Year(s) |
| Gender |
Both |
| Details |
Healthy volunteers aged 18–30 years.
Individuals scoring within the normal range (score less than or equal to 3) on a validated health screening tool (General Health Questionnaire - GHQ-12).
Individuals willing to participate in yoga sessions and provide informed consent.
No history of chronic illness or recent major medical interventions. |
|
| ExclusionCriteria |
| Details |
Individuals currently practicing yoga or other mind-body interventions regularly.
Pregnant or lactating women.
Individuals using medications or supplements known to influence oxidative stress, inflammation, or telomere dynamics. |
|
|
Method of Generating Random Sequence
|
Computer generated randomization |
|
Method of Concealment
|
Sequentially numbered, sealed, opaque envelopes |
|
Blinding/Masking
|
Outcome Assessor Blinded |
|
Primary Outcome
|
| Outcome |
TimePoints |
High-throughput
Quantitative Fluorescence In Situ Hybridization (HT-Q-FISH): A sensitive and precise method that quantifies Mean telomere length (MTL) in kilobases per cell, Percentage of critically short telomeres,Telomere length distribution across leukocyte subsets. |
Telomere length changes are assessed before and after the intervention period of 6 months. |
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
Perceived Stress Scale (PSS):Tool to measure perception of stress in daily life.
WHO-5 Well-Being Index:To assess the subjective psychological well being. |
Perceived Stress Scale and WHO-5 Well-Being Index will be assessed before and after the intervention period of 6 months. |
|
|
Target Sample Size
|
Total Sample Size="20"
Sample Size from India="20"
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" |
|
Phase of Trial
|
Phase 2 |
|
Date of First Enrollment (India)
|
15/12/2025 |
| Date of Study Completion (India) |
Applicable only for Completed/Terminated trials |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Applicable only for Completed/Terminated trials |
|
Estimated Duration of Trial
|
Years="1"
Months="0"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Not Yet Recruiting |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This randomized controlled trial aims to investigate the effect of a structured academic yoga program on telomere length in healthy volunteers. Telomere structures naturally shorten with age, and their accelerated erosion is associated with various age-related diseases and poor health outcomes. Yoga may positively influence telomere length and consequently ,cellular aging .The Study involves 20 participants aged 18 -30 years from the International Institute of Yoga and Naturopathy Medical Sciences (IIYNMS),Chengalpattu. Participants will engage in one hour of regular academic yoga practice, five days a week, for six months. The interventional effectiveness is assessed through measuring the Changes in Telomere length using High-throughput Quantitative Fluorescence In Situ Hybridization (HT-Q-FISH) at baseline and post intervention. By examining the biological and psychological outcomes of yoga practice, this study seeks to provide scientific evidence on its potential as a preventive health strategy for enhancing cellular longevity and overall well-being. |