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CTRI Number  CTRI/2025/07/090353 [Registered on: 07/07/2025] Trial Registered Prospectively
Last Modified On: 05/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Unani 
Study Design  Single Arm Study 
Public Title of Study   Treatment of Ringworm Skin Infection using a Traditional Unani Topical Remedy in patients 
Scientific Title of Study   Efficacy of topical Samagh-e-Arabi (Acacia Arabica Willd) with Sirka (Vinegar) in Quba Mutaqashshir (Tinea Corporis)A Non-Randomized Clinical Trial  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Patel Hafsa Nooruddin 
Designation  PG SCHOLAR 
Affiliation  Government Unani Medical College 
Address  Government Unani Medical College, Department of PG–Moalajat, Rooom No.5M, Arignar Anna Hospital Campus, Arumbakkam, Chennai.

Chennai
TAMIL NADU
600106
India 
Phone  7030310859  
Fax    
Email  hafsapatel2913@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Mushtaq Ahmed MD 
Designation  Professor 
Affiliation  Government Unani Medical College, Chennai 
Address  OP No. 5M Department of PG Moalajat Government Unani Medical College Arignar Anna Hospital Campus Arumbakkam, Chennai

Chennai
TAMIL NADU
600106
India 
Phone  9884156051  
Fax    
Email  drcmushtaq65@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Mushtaq Ahmed MD 
Designation  Professor 
Affiliation  Government Unani Medical College 
Address  OP No.5M Department of PG Moalajat Government Unani Medical College Arignar Anna Hospital Campus Arumbakkam, Chennai

Chennai
TAMIL NADU
600106
India 
Phone  9884156051  
Fax    
Email  drcmushtaq65@gmail.com  
 
Source of Monetary or Material Support  
AAGHIM, Anna Hospital Campus, Arumbakkam, Chennai 600106  
 
Primary Sponsor  
Name  Government Of Tamilnadu 
Address  Government Unani Medical College Arumbakkam,Chennai-600106 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Patel Hafsa Nooruddin  Arignar Anna Government Hospital of Indian Medicine   Department of Moalajat Unani Division, Room No. 5M Arumbakkam, Chennai – 600106 Tamil Nadu, India
Chennai
TAMIL NADU 
7030310859

hafsapatel2913@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Communication of Decision of the Instituitional Ethics Committee(IEC) for Unani Medical Research for PG Scholars of M.D.(Unani) affiliated to The TN Dr. MGR Medical University, Chennai  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: L088||Other specified local infections of the skin and subcutaneous tissue,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  NIL  NIL 
Intervention  Topical Samagh-e-Arabi (Acacia Arabica Willd) with Sirka (Vinegar)  Samagh-e-Arabi (Acacia arabica Willd) will be powdered and soaked in required amount of sirka (vinegar) for topical application on the lesion, ROUTE OF ADMINISTRATION-Topical, DOSAGE-As much as required, twice a day,(after 10-15 minutes wiped with sterile gauze). Duration of Treatment-28days, FOLLOW-UP: 7, 14, 21, 28th day  
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Circumscribed lesions on trunk and limbs with itching, erythema, scales, central clearing with peripheral raised margins.
Participants diagnosed with Positive Mycology (KOH positive).
 
 
ExclusionCriteria 
Details  Patients below the Age of 18 Years and above the age of 60 Years.
Participants suffering from severe systemic or metabolic diseases.
Participants suffering from concomitant conditions, or diseases like Psoriasis, Eczema
Pregnant Or Lactating Women.
Known Cases of Immuno-Compromised States (HIV/ AIDS, Etc.)/ Malignancies.
Participants not willing to follow the protocol
 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Reduction in Total Sign and Symptom Score (TSSS).

KOH Examination:
Complete Elimination of fungal elements in KOH examination at the 28th day of treatment in comparison to baseline
 
Total Sign and Symptom Score (TSSS):7th day,14th day,21st day,28th day

KOH examination: Baseline,28th day 
 
Secondary Outcome  
Outcome  TimePoints 
NIL  NIL 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   18/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Tinea corporis, known as Quba in Unani medicine, refers to superficial fungal infections affecting the skin, excluding the scalp, beard, face, hands, feet and groin. It presents as circular erythematous scaly and hypopigmented patches with central clearing, forming characteristic ring like lesions called Ringworm. Dermatophytes infect the keratinized stratum corneum but cannot penetrate deeper tissues. In Unani medicine, Quba also called Karyun or Dad, is caused by mirrha-e-sawda or abnormal black bile and involves the body natural forces. Quwwat-i-Tabaiyya diverts harmful humor or Khilt-i-Bad to the skin. Symptoms include roughness, itching, scaling, and dry lesions that may appear blackish, reddish, or pus-filled depending on the causative agents. Globally, tinea infections affect twenty to twenty five percent of the population with high prevalence in India. Males are more susceptible due to outdoor exposure, heat, and friction. According to the Unani system of medicine, the treatment of Quba focuses on the causative factors, such as Akhlat, and the disease intensity, duration, and clinical signs. Numerous Traditional healers have also suggested medications with Mudammil-e-Quruh (healing) and Musaffi-i-dam (blood purifier). Unani physicians have placed a strong focus on topical treatment using products like Zimad (paste), Tila (liniment), and Marham (ointment)Conventional medicine relies on antifungals and corticosteroids, but increasing resistance and recurrence highlight the need for safer alternatives. This study evaluates Samagh-e-Arabi (Acacia Arabica) with Sirka (vinegar), a Unani formulation from Kitabul Umda fil Jarahat, as a potential remedy for Quba. The aim is to provide an effective traditional therapeutic option amid rising antifungal resistance and economic burdens in dermatophytosis management.

 
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