| CTRI Number |
CTRI/2025/07/089995 [Registered on: 02/07/2025] Trial Registered Prospectively |
| Last Modified On: |
01/07/2025 |
| Post Graduate Thesis |
No |
| Type of Trial |
Interventional |
|
Type of Study
|
Physiotherapy (Not Including YOGA) |
| Study Design |
Non-randomized, Active Controlled Trial |
|
Public Title of Study
|
Comparison of Mulligan Mobilization Versus PNF on Pain, Function in OA Knee Patients |
|
Scientific Title of Study
|
Comparative Effects of Mulligan Mobilization and PNF on Pain, Function and Mobility in Knee Osteoarthritis: A Quasi-Experimental Study |
| Trial Acronym |
NIL |
|
Secondary IDs if Any
|
| Secondary ID |
Identifier |
| NIL |
NIL |
|
|
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
|
| Name |
Priyanka Salwankar |
| Designation |
Assistant Professor |
| Affiliation |
Datta Meghe College of Physiotherapy Nagpur |
| Address |
109 Chandramani Nagar 9 Acre Nagpur
SDMP Campus Wanadongari Nagpur
Nagpur
MAHARASHTRA
440027
India |
| Phone |
7276634350 |
| Fax |
|
| Email |
priyankasalwankar1234@gmail.com |
|
Details of Contact Person
Scientific Query
|
| Name |
Priyanka Salwankar |
| Designation |
Assistant Professor |
| Affiliation |
Datta Meghe College of Physiotherapy Nagpur |
| Address |
109 Chandramani Nagar 9 Acre Nagpur
SDMP Campus Wanadongari Nagpur
Nagpur
MAHARASHTRA
440027
India |
| Phone |
7276634350 |
| Fax |
|
| Email |
priyankasalwankar1234@gmail.com |
|
Details of Contact Person
Public Query
|
| Name |
Priyanka Salwankar |
| Designation |
Assistant Professor |
| Affiliation |
Datta Meghe College of Physiotherapy Nagpur |
| Address |
109 Chandramani Nagar 9 Acre Nagpur
SDMP Campus Wanadongari Nagpur
Nagpur
MAHARASHTRA
440027
India |
| Phone |
7276634350 |
| Fax |
|
| Email |
priyankasalwankar1234@gmail.com |
|
|
Source of Monetary or Material Support
|
|
|
Primary Sponsor
|
| Name |
Datta Meghe College of Physiotherapy Nagpur |
| Address |
SHRI DATTA MEGHE POLYTECHNIC Campus Wanadongari Nagpur 441110 |
| Type of Sponsor |
Private medical college |
|
|
Details of Secondary Sponsor
|
|
|
Countries of Recruitment
|
India |
|
Sites of Study
|
| No of Sites = 1 |
| Name of Principal
Investigator |
Name of Site |
Site Address |
Phone/Fax/Email |
| Dr Priyanka Salwankar |
Datta Meghe College of Physiotherapy Nagpur |
Datta Meghe College of Physiotherapy, ground floor, Musculoskeletal OPD,Shri Datta Meghe Polytechnic Campus Wanadongari Nagpur
Nagpur
MAHARASHTRA |
7276634350
priyankasalwankar1234@gmail.com |
|
|
Details of Ethics Committee
|
| No of Ethics Committees= 1 |
| Name of Committee |
Approval Status |
| Datta Meghe College of Physiotherapy Ethical Committee |
Approved |
|
|
Regulatory Clearance Status from DCGI
|
|
|
Health Condition / Problems Studied
|
| Health Type |
Condition |
| Patients |
(1) ICD-10 Condition: M179||Osteoarthritis of knee, unspecified, |
|
|
Intervention / Comparator Agent
|
| Type |
Name |
Details |
| Intervention |
Mulligan Mobilization Technique |
four-week intervention of Maitland-based Mulligan Mobilization applied to the knee joint using mobilization with movement techniques by a trained physiotherapist. |
| Comparator Agent |
Proprioceptive Neuromuscular Facilitation |
four-week intervention,Proprioceptive Neuromuscular Facilitation stretching and strengthening techniques applied to improve mobility and muscle control. |
|
|
Inclusion Criteria
|
| Age From |
40.00 Year(s) |
| Age To |
65.00 Year(s) |
| Gender |
Both |
| Details |
Patients who have been clearly diagnosed with osteoarthritis (OA) of the knee based on the American College of Rheumatology guidelines
At least six months of knee pain
Degradation of KellgrenLawrence grade 1 or 2 joint cartilage
BMI (body mass index) less than 35 |
|
| ExclusionCriteria |
| Details |
Intra-articular injections or physical treatment throughout the previous three months
Four weeks of oral corticosteroid usage
The past of knee surgery
Systemic conditions such as rheumatoid arthritis
Any recent injury
|
|
|
Method of Generating Random Sequence
|
Other |
|
Method of Concealment
|
Not Applicable |
|
Blinding/Masking
|
Open Label |
|
Primary Outcome
|
| Outcome |
TimePoints |
Numerical pain rating scale
Lequesne Algofunctional Index
|
4 weeks
|
|
|
Secondary Outcome
|
| Outcome |
TimePoints |
| Timed Up and Go Test |
4 weeks |
|
|
Target Sample Size
|
Total Sample Size="46"
Sample Size from India="46"
Final Enrollment numbers achieved (Total)= "0"
Final Enrollment numbers achieved (India)="0" |
|
Phase of Trial
|
N/A |
|
Date of First Enrollment (India)
|
15/07/2025 |
| Date of Study Completion (India) |
12/01/2026 |
| Date of First Enrollment (Global) |
Date Missing |
| Date of Study Completion (Global) |
Date Missing |
|
Estimated Duration of Trial
|
Years="0"
Months="2"
Days="0" |
|
Recruitment Status of Trial (Global)
|
Not Applicable |
| Recruitment Status of Trial (India) |
Completed |
|
Publication Details
|
N/A |
|
Individual Participant Data (IPD) Sharing Statement
|
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
|
|
Brief Summary
|
This quasi-experimental investigation intends to explore the effects of Mulligan Mobilization and Proprioceptive Neuromuscular Facilitation (PNF), on individuals with knee osteoarthritis. A total of 46 participants will be recruited aged 40 to 65 and will be split into two intervention groups. Main outcomes include pain severity and functional disability measured using the Numerical Pain Rating Scale (NPRS) and Lequesne Algofunctional Index Rating Scale. The secondary outcome, mobility, will be measured using the Timed Up and Go (TUG) test. All outcome measures will be completed at baseline and each post-intervention measure after 4 weeks. The purpose of this study is to compare the two commonly used physiotherapy techniques in regards to their effectiveness to reduce pain, functional disability and improve mobility in people with knee osteoarthritis. |