This is a prospective, blinded, comparative diagnostic study conducted at Ayothidoss Pandithar Hospital, National Institute of Siddha, Chennai, over 18 months. The study aims to evaluate the effectiveness of Siddha Naadi examination in diagnosing anovulatory menstruation in women aged 20–45 years, by comparing it with the gold standard progesterone assay. A total of 100 female participants, 50 participants with  with menstrual irregularities (like menorrhagia, oligomenorrhea, metrorrhagia) and 50 with regular menstruration  will be enrolled. They will undergo hormonal testing (FSH, LH, estrogen, progesterone, etc.) and ultrasound follicular studies. Anovulation will be confirmed through a progesterone dipstick test. Participants will then be randomly and blindly presented to the principal investigator, who will perform Naadi examination without knowing the patient’s identity or diagnosis. An additional (unblinded) investigator will assess Naadi beforehand for comparison. The primary objective is to determine the sensitivity and specificity of Naadi in detecting anovulation. Secondary objectives include calculating the positive and negative predictive values, likelihood ratios, and documenting Naadi patterns across different stages of anovulation. This study is expected to provide scientific validation for the diagnostic utility of Siddha Naadi examination in reproductive health.