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CTRI Number  CTRI/2025/07/091915 [Registered on: 28/07/2025] Trial Registered Prospectively
Last Modified On: 25/07/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Other 
Public Title of Study   A Study to Compare the Effects of Blood Flow Restriction Technique and Muscle Energy Technique on Isokinetic Strength of Quadricep Muscle in knee Osteoarthritis Patients. 
Scientific Title of Study   To Compare the Impact of Blood Flow Restriction Technique and Muscle Energy Technique on Isokinetic Strength of Quadricep Muscle in Knee Osteoarthritis Patients. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Aakanksha Dhok 
Designation  MPT Musculoskeletal student 
Affiliation  Banarsidas Chandiwala Institute of Physiotherapy 
Address  Musculoskeletal Physiotherapy Department , Banarsidas Chandiwala Institute of Physiotherapy , Chandiwala Estate , Metro Station , Maa Anandmai Marg, Near Govindpuri, Shyam Nagar , Kalkaji , New Delhi, Delhi South 110019.

South
DELHI
110019
India 
Phone  7748801440  
Fax    
Email  aakankshadhok1998@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Dr Prithvi Parasher  
Designation  Assistant Professor 
Affiliation  Banarsidas Chandiwala Institute of Physiotherapy 
Address  Musculoskeletal Physiotherapy Department , Banarsidas Chandiwala Institute of Physiotherapy , Chandiwala Estate , Metro Station , Maa Anandmai Marg, Near Govindpuri, Shyam Nagar , Kalkaji , New Delhi, Delhi South 110019.

South
DELHI
110019
India 
Phone  9625603419  
Fax    
Email  Prithvi@bcip.ac.in  
 
Details of Contact Person
Public Query  
Name  Dr Prithvi Parasher  
Designation  Assistant Professor 
Affiliation  Banarsidas Chandiwala Institute of Physiotherapy 
Address  Musculoskeletal Physiotherapy Department , Banarsidas Chandiwala Institute of Physiotherapy , Chandiwala Estate , Metro Station , Maa Anandmai Marg, Near Govindpuri, Shyam Nagar , Kalkaji , New Delhi, Delhi South 110019.

South
DELHI
110019
India 
Phone  9625603419  
Fax    
Email  Prithvi@bcip.ac.in  
 
Source of Monetary or Material Support  
Banarsidas Chandiwala Institution of Physiotherapy , Chandiwala Estate, Maa Anandamayee Marg, Kalkaji , New Delhi-110019  
 
Primary Sponsor  
Name  AAKANKSHA DHOK 
Address  Chandiwala Estate, Maa Anandamayee Marg, Kalkaji , New Delhi-110019 
Type of Sponsor  Other [SELF] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
AAKANKSHA DHOK  BANARSIDAS CHANDIWALA INSTITUTE OF PHYSIOTHERAPY  Musculoskeletal Physiotherapy Department , Banarsidas Chandiwala Institute of Physiotherapy , Chandiwala Estate , Metro Station , Maa Anandmai Marg, Near Govindpuri, Shyam Nagar , Kalkaji , New Delhi, Delhi South 110019.
South
DELHI 		 7748801440

aakankshadhok1998@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
The Institutional Ethical Commitee of Banarsidas Chandiwala Institute of Physiotherapy( IEC-BCIP)  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Healthy Human Volunteers 
 
Intervention / Comparator Agent  
Type  Name  Details 
Comparator Agent  Blood Flow Restriction Technique  Intervention will be given for 5 days per week for 8 weeks  
Intervention  Muscle Energy Technique   Intervention will be given for 5 days per week for 8 weeks. 
 
Inclusion Criteria  
Age From  40.00 Year(s)
Age To  55.00 Year(s)
Gender  Both 
Details  Age 40 to 55 years old.
Individuals with grade 2 or 3 for knee OA Kellgren Lawrence grade .
Radiographic criteria Presence of osteophytes & Joint space narrowing .
Clinical criteria Knee pain , stiffness , limited function , crepitus.
Body Mass Index BMI between 18.5 and 40 kg per m².
Both Male and Female are included. 
 
ExclusionCriteria 
Details  Age Less than 45 years or greater than 55 years
Recent knee surgery or arthroscopy Within the past 6 months
Knee joint infection or septic arthritis Active or recent infection
Severe knee OA Kellgren Lawrence grade 4.
Individuals with systemic disorders such as neurological , cardiovascular , respiratory or psychological conditions.
Individuals with Cognitive impairment or dementia.
Contraindications for BFR training Deep vein thrombosis, peripheral artery disease, or other circulatory impairments 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Strength (Isokinetic Dynamometer)
 		 8 Weeks
 
 
Secondary Outcome  
Outcome  TimePoints 
Range Of motion (Isokinetic Dynamometer)  8 weeks 
 
Target Sample Size   Total Sample Size="86"
Sample Size from India="86" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   06/08/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Osteoarthritis (OA) also called as an  Osteoarthrosis or degenerative joint disease, it is the most common form of chronic disorder of synovial joints. In patients with OA knee, pain would be the earliest symptom, and weakness in the quadriceps muscle compared to healthy persons. Quadriceps muscle weakness may contribute to the substantial functional deficit that occur with disease progression. 

This study aims to study the impact of Blood flow restriction technique and Muscle Energy Technique on  on isokinetic strength of Quadricep Muscle in knee Osteoarthritis Patients.

GROUP 1 Autogenic Inhibition

Technique Used  Post Isometric Relaxation 

Protocol

Position Prone, hip flexed to 90°

Isometric contraction of agonist muscle (knee flexors) at 20% strength

Hold for 5 seconds  5 seconds relaxation

2 sets of 5 reps

Frequency 5 sessions per week for 8 weeks

Additional Modalities

Hot Moist Pack  15 mins over knee

Interferential Therapy (IFT)  4 pole method, 20 mins

Ultrasound Therapy 1 MHz, 1.5 W per cm², continuous mode, 5 cm transducer

GROUP 2 Reciprocal Inhibition

Technique Used Reciprocal Inhibition Stretching

Protocol

Position Prone, hip flexed to 90°

Isometric contraction of antagonist muscle (likely knee extensors) at 20% strength

Hold for 5 seconds, 5 seconds relaxation

2 sets of 5 reps

Frequency 5 sessions per week for 8 weeks

Additional Modalities

Hot Moist Pack  15 mins over knee

Interferential Therapy (IFT)  4 pole method, 20 mins

Ultrasound Therapy 1 MHz, 1.5 W per cm², continuous mode, 5 cm transducer

GROUP 3  Blood Flow Restriction (BFR) Technique

Technique Used  BFR with Low-Load Resistance Training

Protocol

Application of pneumatic cuff proximally to the target muscle

Pressure induces partial arterial and full venous occlusion

Resistance exercises at 20–30 percentage of 1RM, 15–30 reps, 30second rest between sets

                 Frequency 5 sessions per week for 8 weeks

Additional Modalities

Hot Moist Pack  15 mins over knee

Interferential Therapy (IFT)  4-pole method, 20 mins

Ultrasound Therapy  1 MHz, 1.5 W per cm², continuous mode, 5 cm transducer

Common Interventions in All Group

Hot Moist Pack  Applied for 15 minutes to the affected knee

Interferential Therapy (IFT)  Four-pole vector method, 20 minutes

Ultrasound Therapy  Continuous 1 MHz US at 1.5 W per cm² over knee joint

 


 
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