Cardiovascular Diseases (ischemic heart disease and cerebrovascular disease conditions), are the leading cause of death worldwide. Atherosclerosis plays a central role, with early fatty streaks progressing to late complex atheromas. Vascular calcification has been shown to strongly correlate with degree of atherosclerosis.

Over the last several decades, the global prevalence and mortality of atherosclerotic cardiovascular disease (ASCVD) has increased. Identifying risk factors associated with ASCVD have been paramount to informing public health policies and interventions to reduce ASCVD risk. Assessing ASCVD risk based on CVD risk factors, including hypercholesterolemia, hypertension, tobacco use, and physical inactivity helps guide treatment, primarily aimed at reducing low-density lipoprotein-cholesterol (LDL-C) in primary prevention, as cumulative exposure to LDL-C is the main driver for ASCVD.

The ASCVD risk score, developed by the American College of Cardiology, is a calculation of person’s 10-year risk of developing a cardiovascular event, such as a heart attack or stroke. This risk estimate considers age, gender, race, cholesterol levels, blood pressure, medication use, diabetic status, and smoking status. However, ASCVD risk score is not validated for Indian population.

Coronary Artery Calcium (CAC) scoring has emerged as a widely available tool for stratifying cardiovascular risk, predicting patient outcomes, and guiding therapy. CAC is a highly specific marker for coronary atherosclerosis.

For the cardiovascular risk identification, different markers and clinical investigations are available. In this study, the participant will be stratified into different cardiovascular risk category based on different clinical risk estimation parameters and methods.  Overall, this study will help in identifying ASCVD risk levels of the individuals and correlate risk levels in appropriate cardiac risk category who are asymptomatic for coronary artery disease.