1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [priyabalu1907@gmail.com].
   


6. For how long will this data be available start date provided 30-06-2025 and end date provided 20-06-2030?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

This randomized controlled clinical trial aims to evaluate and compare the clinical, radiographic, and antimicrobial efficacy of three different root canal disinfection protocols—Triple Antibiotic Paste (TAP), 810 nm diode laser, and 980 nm diode laser—in the context of pulp revascularization for necrotic immature permanent anterior teeth in children. Pulp revascularization, a regenerative endodontic approach, offers a biologically based treatment for teeth with open apices. The success of this technique depends heavily on effective disinfection while preserving the viability of stem cells in the apical papilla.

The study will involve 30 children aged 7–9 years with non-vital, immature maxillary central incisors. Participants will be randomly divided into three groups (n=10 per group). Group 1 will receive TAP for 3 weeks; Group 2 will undergo disinfection using an 810 nm diode laser; Group 3 will receive 980 nm diode laser treatment. Microbial samples will be collected pre- and post-disinfection to evaluate the reduction in colony-forming units (CFUs). All groups will follow the American Association of Endodontists (AAE) 2021 protocol for regenerative endodontics.

Clinical and radiographic outcomes, including root length, dentin wall thickness, apical closure, and post-operative symptoms, will be assessed at 3, 6, 9, and 12 months. A final CBCT scan at 12 months will help evaluate root development and healing. Statistical analysis will be performed using SPSS v25, with appropriate tests based on data distribution.

This study is expected to provide valuable insights into the most biologically favorable and clinically effective disinfection strategy for regenerative endodontics. The findings will contribute to improved protocols for managing necrotic immature permanent teeth in pediatric patients, enhancing both treatment success and long-term prognosis. Ethical clearance has been obtained for this low-risk clinical trial involving children and minimally invasive procedures.