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CTRI Number  CTRI/2025/10/095702 [Registered on: 08/10/2025] Trial Registered Prospectively
Last Modified On: 09/10/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   To evaluate the efficacy of CHANDRAMANDAL CHEDAN(Excision) with CHANDRAMANDAL CHEDAN SHATRA Followed By TAILDAGHDHA In manegement of KADAR with special reference to CORN  
Scientific Title of Study   A Randomised clinical comparative study of CHANDRAMANDAL CHEDAN KARMA(Excision) By modified CHANDRAMANDAL CHEDAN SHATRA Followed by TAILDAGHDHA And Conventional Excision in Manegement of KADAR with special reference to CORN  
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dipak kishor Nandre  
Designation  PG Scholar 
Affiliation  Matoshri Asarabai Darade Ayurved Hospital affiliated with Matoshri Asrabai Darade Ayurved College 
Address  Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Nashik
MAHARASHTRA
423401
India 
Phone  8412977825  
Fax    
Email  nandredipak29@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Nilesh Nivruttirao Chavan  
Designation  Profesor Department Of Shalyatantra  
Affiliation  Matoshri Asarabai Darade Ayurved Hospital affiliated with Matoshri Asrabai Darade Ayurved College  
Address  Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Nashik
MAHARASHTRA
423401
India 
Phone  9420694499  
Fax    
Email  Shahu7099@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Nilesh Nivruttirao Chavan  
Designation  Profesor Department Of Shalyatantra  
Affiliation  Matoshri Asarabai Darade Ayurved Hospital affiliated with Matoshri Asrabai Darade Ayurved College  
Address  Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Matoshri Asarabai Darade Ayurved Hospital, OPD NO 04/05 Ground Floor, Matoshri Asrabai Darade Ayurved College,SND Campus at Babhulgaon Tal -Yeola Dist- Nashik Nashik MAHARASHTRA 423401 India
Nashik
MAHARASHTRA
423401
India 
Phone  9420694499  
Fax    
Email  Shahu7099@gmail.com  
 
Source of Monetary or Material Support  
Matoshri Asarabai Darade Ayurved College And Matoshri Asarabai Darade Ayurved Hospital Babhulgaon Tal Yeola Dist - Nashik Maharastra 423401  
 
Primary Sponsor  
Name  Matoshri Asarabai Darade Ayurved college  
Address  Department Of Shalyatantra Matoshri Asrabai Darade Ayurved College and Shalyatanta OPD,Matoshri Asarabai Darade Hospital Babhulgaon  
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
DrDipak Kishor Nandre  Matoshri Asarabai Darade Ayurved College and Hospita  OPD no 04/05 Shalya OPD Ground Floor Matoshri Asarabai Darade College SND Campus Babhulgaon TAL- Yeola Dist- Nashik Nashik MAHARASHTRA
Nashik
MAHARASHTRA 
8412977825

nandredipak29@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Matoshri Asarabai Darad Ayurved College Ethical Committee   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:L00-L99||Diseases of the skin and subcutaneous tissue. Ayurveda Condition: KADARAH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Comparator ArmProcedure-candramaNDalavat-CedaH, चन्द्रमण्डलवत्-छेदः (Procedure Reference: , Procedure details: )
2Comparator Arm (Non Ayurveda)-Standard corn excision with surgical blade corn is excised with strandard procedure that is pure excision of corn with surgical blade
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  70.00 Year(s)
Gender  Both 
Details  Patients with signs of kadara(corn) Saruk (pain) occasionally,shape like that of kolaphalan,sakila(cone) ,Kathina ( hard /thickened ) and Nimnormadhya ( it is centrally depressed and raised peripherally) will be selected
Age : Between 18-70 years irrespective of gender
Patients will be selected who are willing to give informed consent and ready to comply with the protocol. 
 
ExclusionCriteria 
Details  Patients with uncontrolled systemic disorders like Diabetes ,Hypertension .
Patients with infective conditions like HIV and HbsAg will be excluded
Pregnant women  
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Not Applicable 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Parameters will be noted down Before and after treatment
1.Pain
2. Itching
3. Strava
4. Tenderness
5. Wound healing
6. Infection
before on 1st visit and then after interventions parameters calculated  
1st ,5th,10th,15 th and 25th day 
 
Secondary Outcome  
Outcome  TimePoints 
A)To study etiopathology of Kadar in detail i.e Corn in ayurvedic aspect and
modern aspect
B ) To study the effectiveness of CHANDRAMANDAL CHEDAN with MANDALGRA
CHEDAN SHATRA
C) To study the Mode of action of TAILDAGHDHA 
after all cases studied in 1-1.5 year of time
 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   20/10/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  20/10/2025 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="6"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Open to Recruitment 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details
Modification(s)  
N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary
Modification(s)  
Corn is a thickened area of skin caused by pressure ,commonly found on soles and
toes .It looks like white circular spot that can be very painful when touched ,corns
can also be formed beacause of some forgein body that stuck in skin after
penetration some part stuck in there causes infection and not treated then devoveps
fibrous mass it can also develop over side and tip of the toes ,through it is less
common sometimes corn apper between the toes, where they are softer and less
painful
Corns are painful because they have a cone shaped core that can press on a nerve
,causing severe discomfort and making it feel like you,re walking with a sharp pebble
in your shoe .
The incidence of corn on feet has been reported to range from 5% to 20% . so the
privalance rate is 2.07 % [25]
Corns can be compared to a condition called KADAR ,as described in the ancient
Ayurvedic texts .In the classical literature ,such as the shushrut samhita ,kadar has
been categorized under the Kshudra Rogas [1].It is caused by an imbalance of the vata
and kapha doshas ,which then affects the rakta and meda dhatus .
Clinical presentation includes Shauk ( Pain ) occasionally ,shape like that of
kolaphala ,sakila (Cone ) ,Kathina (Hard /Thickened ) and Nimnormadhya ( It is
centrally dipressed and raised peripherally ) .If condition left untreated undergoes
paka ,leading to strava ( Discharge )
If Kadar is left untreated ,it can cause back,hip,and knee pain due to changes in
walking patten from severe discomfort .Treating corns involves removing the
abnormal tissue using methods like salicylic acid application,CRYOHERAPY ,LASER
treatment ,electric and chemical CAUTERIZATION ,and SURGICAL EXCISION .These
treatments are invasive modalities ,expensive and require wound care in post –
surgical period .Moreover ,there is lot of recurrence rate .
In Conventionalcorn excision once anesthetized ( either by IV sedation or local
2
anesthesia ) ,the surgeon will completely remove the corn and underlying bony
prominence .
After corn removal surgery ,patient may feel throbbing ,aching ,burning ,or even
numbness in your foot . surgeon may recommend to elevate foot above the level of
heart for at least 48 hours after the surgery .also Folowed by pain medications .this
will aid with pain relief and minimize the swelling after surgery Surgeon will
probabaly advise to modify placing any weight on the foot that was oprated on.You
wil be placed in either a surgical shoe or boot and your surgical dressing canno get
wet .Most likely recommended that you keep your foot dry wih a shower bag until
your incision heal .Typically it takes 6 weeks to 3 months to fully recover from corn
removal surgery .The recovery time truly depends upon he extent of the surgery and
any complications that may arise from it .
Acharya SHUSHRUT mentioned MANDALAGRA SHATRA for CHEDAN KARMA which
is beneficial for CHEDAN KARMA in HASTA( Hand ) and PAD ( Leg ) in
SHAATRAVACHARNYA AHYAY[2] it should be VRUNTA (Round) MUKH , KHURAKAR(
Sharp) and with proper handle for grip.[3]
Acharya SHUSHRUT also mentioned TAILDAGHDHA after chedan karma in
MANEGEMENT of kadar in KSHUDRAROGCHIKTSA ADHYAY[1] . for better results in
this procedure after proper removal of con under all aspetic mesurments it should
be burned with tela so it would heal faster and SNEHAN KARMA also be done within
it for softening of wound edges .
This study is carried out with an aim for betterment of corn excision procedure with
CHANDRAMANDAL CHEDAN by MANDALAGRA CHEDAN SHASTRA FOLLOWED BY
TAIlDAGHDHA as it is very cost effective ,rapidly performed as compared to
Conventionalcorn excision ,easy procedure ,instruments can be reused after proper
sterilization ,realtively easy to learn ,bleeding is less,wound care is less .

Amongst from all the patients suffering from corn are from
economically lower class they don’t have that much money and time for recovery for
the betterment.Also they bear a fear regarding the surgery and also don’t have that
3
much time for recovery .As most of patients are farmers and workers due to that
thing they are not financially stable. They will have to join there workplace as soon as
possible after surgery .CHANDRAMANDAL CHEDAN WITH MANDALAGRA CHEDAN
SHATRA FOLLOWED BY TAILDAGHDHA is simple and safe office procedure .The
incidence of recurrence is reduced as the whole corn with the central core is excised
.Mutiple corns can be removed in a single sessions .
There is immediate pain relif ,no requirement of rest and patient can return to
the workplace immediately .This is minimally invasive and less messy technique with
minimal blood loss .
Even through ,Conventionalcorn excision is the line of treatment for KADAR(
Corn) ,it has been throught to treat the cases of KADAR wih CHANDRAMANDAL
CHEDAN WITH MANDALAGRA CHEDAN SHATRA FOLLOWED BY TAILDAGHDHA i.e.
CHEDAN FOLLOWED BY SNEHAN .Hence in this present study one group of subjects
will be treated with CONVENTIONALCORN EXCISION and OTHER group of subjects
will be treated with CHANDRAMANDAL CHEDAN WITH MANDALAGRA CHEDAN
SHATRA FOLLOWED BY TAILDAGHDHA .Thus CHEDAN FOLLOWED BY SNEHAN will
be subjected for trial and the results of he same will be assessed and compared .The
generated data wil be calculated with suitable statistical methods after completion of
clinical study .
 
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