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CTRI Number  CTRI/2025/07/090392 [Registered on: 07/07/2025] Trial Registered Prospectively
Last Modified On: 05/07/2025
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Dentistry 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   EXPLORING THE HEALING POTENTIAL OF DRUMSTICK LEAVES POWDER IN POSTOPERATIVE ORAL WOUNDS  
Scientific Title of Study   HEALING EFFICACY OF MORINGA OLEIFERA LEAVES POWDER IN INTRAORAL WOUND HEALING : A COMPARATIVE STUDY 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Nehil Saran 
Designation  Senior Resident 
Affiliation  King George Medical College 
Address  Department of Periodontology, Faculty of Dental Sciences,King George Medical College, Sahamina Road,Lucknow,Uttar Pradesh

Lucknow
UTTAR PRADESH
226003
India 
Phone  9260927326  
Fax    
Email  nehilsaran85@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Nehil Saran 
Designation  Senior Resident 
Affiliation  King George Medical College 
Address  Department of Periodontology, Faculty of Dental Sciences,King George Medical College, Sahamina Road,Lucknow,Uttar Pradesh

Lucknow
UTTAR PRADESH
226003
India 
Phone  9260927326  
Fax    
Email  nehilsaran85@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Nehil Saran 
Designation  Senior Resident 
Affiliation  King George Medical College 
Address  Department of Periodontology, Faculty of Dental Sciences,King George Medical College, Sahamina Road,Lucknow,Uttar Pradesh

Lucknow
UTTAR PRADESH
226003
India 
Phone  9260927326  
Fax    
Email  nehilsaran85@gmail.com  
 
Source of Monetary or Material Support  
Department Of Periodontology , Faculty of Dental Sciences , King George Medical College,Lucknow 
 
Primary Sponsor  
Name  Dr Nehil Saran 
Address  Department of Periodontology, Faculty of Dental Sciences,King George Medical College,Lucknow U.P 
Type of Sponsor  Other [Self] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Nehil Saran  Department of Periodontology  5th Floor, Room No. 14, Department of Periodontology, New Dental Building, Faculty of Dental Sciences,King George Medical College, Sahamina Road,Lucknow,Uttar Pradesh
Lucknow
UTTAR PRADESH 
9260927326

nehilsaran85@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
King George Medical University Insitutional Ethics Committee Lucknow   Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Healthy Human Volunteers  Intraoral postoperative 
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure- (Procedure Reference: , Procedure details: Periodontal Dressing mixed with moringa leaves powder & applied to intraoral wounds)
2Comparator Arm (Non Ayurveda)-Periodontal dressing Non eugenol periodontal dressing
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Individuals having pocket depth 04 millimetre or more than 04 millimeters, more than 20 teeth present in the oral cavity, with 30 percent of teeth having Periodontitis. 
 
ExclusionCriteria 
Details  Participants with a history of any systemic disease,Pregnant and lactating females,Participants with a history of smoking,Participants who have undergone any periodontal treatment in the past 06 months prior to enrollment,History of antibiotic or antiinflammatory or mouthwash use in past 06 months prior to enrollment. 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   On-site computer system 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
Wound Healing effect of Moringa oleifera leaves powder on intraoral wounds.  at 01 week and 01 month followup respectively 
 
Secondary Outcome  
Outcome  TimePoints 
Participants satisfaction level regarding wound healing and postoperative discomfort assessed by Likert scale 1932  At 01 month follow up 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   17/07/2025 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  
This split-mouth clinical study aims to evaluate the woundhealing effects of Moringa oleifera also known as drumstick leaf powder, in postoperative wounds. The minimum sample size is 60 sites, and they are randomly assigned using computer software into two groups. One group will serve as the control site, and the other as the test site. One site will receive only periodontal dressing, while the other site will receive periodontal dressing combined with Moringa oleifera leaf powder.

Participants will be selected based on specific inclusion criteria, which are pocket depth equal to or greater than four millimeters, age above eighteen years, presence of more than twenty teeth, and at least thirty percent of the teeth affected by periodontitis. The exclusion criteria include a history of any systemic disease, pregnancy or lactation, smoking, having undergone periodontal treatment within the past six months, and the use of antibiotics, anti-inflammatory drugs, or mouthwash in the last six months.

Soft tissue healing will be assessed at one week and one month after the procedure using the Early Healing Index developed by Wachtel 2003  and the Healing Index by Landry in 1988. Patient satisfaction regarding wound healing and postoperative discomfort will be evaluated using a 5point Likert scale. Ethical approval will be obtained before the start of the study
 
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