Male infertility can be defined as an inability to induce conception, due to defect in spermatozoic functions like low sperm count, unhealthy sperm production, low sperm motility and altered delivery of sperms due to altered physiology of male reproductive system. Infertility is one of the major issues of concern among couples worldwide. Approximately 40-50% male infertility cases are reported in India, out of which sperm parameters are the main reason for 2% of cases. Oligozoospermia refers specifically to a condition in which sperm concentration below the lower reference limit of 15 million sperm/mL of ejaculate. The standard of care is antioxidants, vitamin supplements, clomiphene citrate, which increases the production of FSH and LH hormones which increases the testosterone production leading to increase in the sperm count. In Ayurveda we have scattered references of ksheena shukra mentioned under asta shukra dusti. Ksheena shukra is vata and pitta dosha pradhana. It is characterized by both qualitative and quantitative reduction in shukra dhatu. Shukra is one of the sapta dhatus. Shukra is the final dhatu that is created from the prasada bhaga (essence) of the majja dhatu and is also thought to be the essence of all the dhatus. Virechana is Vata anulomaka and Pitta rechaka, hence indicated in ksheena shukra caused due to vitiation of vata and pitta dosha. As quoted in Ayurveda classics, Ghrita is having shukra vardhaka property, hence shamananga snehana with Amritaprasha ghrita is chosen. Amritaprasha Ghrita is indicated in nashtashukra, durbala and streeprasakta rogi and has brimhana effect.