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CTRI Number  CTRI/2026/01/102275 [Registered on: 28/01/2026] Trial Registered Prospectively
Last Modified On: 27/01/2026
Post Graduate Thesis  No 
Type of Trial  Interventional 
Type of Study   Physiotherapy (Not Including YOGA) 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   The Role of Blood Flow Restriction Training in Building Strength and Performance in ACL Rehabilitation in Indian Athletes 
Scientific Title of Study   Enhancing ACL Rehabilitation in Indian Athletes: Evaluating the effects of Blood Flow Restriction Training on Muscle Strength, Hypertrophy and Functional Performance 
Trial Acronym  nil 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Sadhan Berry 
Designation  Associate Professor 
Affiliation  ISIC INSTITUTE OF REHABILITATION SCIENCES 
Address  TP- 112, Maurya ENCLAVE, Pitampura, DELHI-110034
SECTOR - C , VASANT KUNJ, NEW DELHI -110070
South West
DELHI
110034
India 
Phone  9818098441  
Fax    
Email  sadhan27@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Sadhan Berry 
Designation  Associate Professor 
Affiliation  ISIC INSTITUTE OF REHABILITATION SCIENCES 
Address  TP- 112, Maurya Enclave, Pitampura, DELHI-110034
SECTOR - C , VASANT KUNJ, NEW DELHI -110070
South West
DELHI
110034
India 
Phone  9818098441  
Fax    
Email  sadhan27@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Sadhan Berry 
Designation  Associate Professor 
Affiliation  ISIC INSTITUTE OF REHABILITATION SCIENCES 
Address  TP- 112, Maurya Enclave, Pitampura DELHI-110034
SECTOR - C , VASANT KUNJ, NEW DELHI -110070
South West
DELHI
110034
India 
Phone  9818098441  
Fax    
Email  sadhan27@gmail.com  
 
Source of Monetary or Material Support  
School of Physiotherapy, SGT University, Gurgaon 
 
Primary Sponsor  
Name  Nil 
Address  Nil 
Type of Sponsor  Other [Nil] 
 
Details of Secondary Sponsor  
Name  Address 
Nil  Nil 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Pooja Anand  SGT University  Room no. 419, School of Physiotherapy, Block-B, 4th Floor,
Gurgaon
HARYANA 
9810240409

pooja.physiotherapy@sgtuniversity.org 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional ethical committee faculty of physiotherapy  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: M708||Other soft tissue disorders related to use, overuse and pressure,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  BFR Group  Total duration: 8 weeks, Week 0–2 (Phase I – Acute / Protection Phase): Goals: Control pain and effusion, restore knee range of motion, prevent quadriceps inhibition. Interventions: Cryotherapy, compression, heel slides, patellar mobilization. BFR Exercises: Quadriceps sets, straight leg raises, ankle pumps at 60% LOP. Week 3–4 (Phase II – Early Strengthening Phase): Goals: Improve muscle strength and achieve full knee ROM. BFR Exercises: Seated knee extension, mini squats, step-ups, hamstring curls using resistance bands at 70–80% LOP. Week 5–6 (Phase III – Neuromuscular Control Phase): Goals: Enhance balance, proprioception, and dynamic knee stability. Exercises: Split squats, lateral step-downs, single-leg stance with perturbations. BFR used selectively for strengthening exercises. Week 7–8 (Phase IV – Functional Strengthening Phase): Goals: Prepare athlete for return to sport-specific activities. Exercises: Lunges, Bulgarian squats, agility drills, controlled plyometric activities. BFR may be used as an adjunct for accessory strength training. 
Comparator Agent  Conventional therapy  Total duration: 8 weeks ACL Rehabilitation 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  35.00 Year(s)
Gender  Both 
Details  MRI-confirmed partial ACL tear involving less than 50% of fibers
Recreational or competitive Indian athletes
Absence of knee instability or giving-way episodes 
 
ExclusionCriteria 
Details  Complete ACL rupture
Associated Grade III ligament injuries
Meniscal root tears
History of vascular disorders or deep vein thrombosis
Previous knee surgery 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Alternation 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Quadriceps and hamstring muscle strength  baseline, 4 weeks, 8 weeks 
 
Secondary Outcome  
Outcome  TimePoints 
Muscle hypertrophy, Functional performance  0 weeks, 4 weeks, 8 weeks 
 
Target Sample Size   Total Sample Size="50"
Sample Size from India="50" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   N/A 
Date of First Enrollment (India)   10/02/2026 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Anterior Cruciate Ligament (ACL) injuries are common among young Indian athletes and often result in persistent deficits in muscle strength and functional performance despite structured conservative rehabilitation. Quadriceps and hamstring weakness, impaired functional capacity, and delayed return to sport increase the risk of re-injury and limit athletic performance. Blood Flow Restriction (BFR) training has emerged as a novel rehabilitation strategy that enables strength and hypertrophy gains using low-intensity exercise, thereby reducing joint stress and potentially enhancing recovery outcomes.This study aims to evaluate the effectiveness, safety, and feasibility of adding BFR training to a conventional rehabilitation program in young Indian athletes with unilateral ACL injuries managed conservatively. The primary objective is to compare changes in quadriceps and hamstring muscle strength between the BFR group and a control group receiving conventional exercise alone. Secondary objectives include assessing functional performance, return-to-sport readiness, adherence, and adverse events. This will be a single-blind, randomized controlled trial involving 60 Indian athletes aged 18–35 years with MRI-confirmed unilateral ACL injury. Participants will be randomly allocated to either a 8-week BFR-assisted rehabilitation program or a standard rehabilitation program. Outcomes will be assessed at baseline, 4 weeks, and 8 weeks using isokinetic strength testing, muscle hypertrophy measures, functional performance tests, and validated patient-reported outcome measures.

 
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